Basic Information:

  VIRBase ID:  

HHID00008587

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          BLOC1S5:  NM_001199322     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	BLOC1S5
miRBase Accession/Entrez ID	MIMAT0004512	63915
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BLOS5//HPS11//MU//MUTED

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BLOC1S5	chr6:8014631(-) A-I      3'UTR chr6:8014686(-) A-I      3'UTR chr6:8014689(-) A-I      3'UTR chr6:8014753(-) A-I      3'UTR chr6:8014622(-) A-I      3'UTR chr6:8014613(-) A-I      3'UTR chr6:8014747(-) A-I      3'UTR chr6:8014639(-) A-I      3'UTR chr6:8014763(-) A-I      3'UTR chr6:8014773(-) A-I      3'UTR chr6:8014542(-) A-I      3'UTR chr6:8014554(-) A-I      3'UTR chr6:8014574(-) A-I      3'UTR chr6:8014579(-) A-I      3'UTR chr6:8014612(-) A-I      3'UTR chr6:8014779(-) A-I      3'UTR chr6:8014604(-) A-I      3'UTR chr6:8014609(-) A-I      3'UTR chr6:8014678(-) A-I      3'UTR chr6:8014700(-) A-I      3'UTR chr6:8014734(-) A-I      3'UTR chr6:8014635(-) A-I      3'UTR chr6:8014567(-) A-I      3'UTR chr6:8014645(-) A-I      3'UTR chr6:8014671(-) A-I      3'UTR chr6:8014780(-) A-I      3'UTR chr6:8014674(-) A-I      3'UTR chr6:8014786(-) A-I      3'UTR chr6:8014529(-) A-I      3'UTR chr6:8014738(-) A-I      3'UTR chr6:8014676(-) A-I      3'UTR chr6:8014675(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BLOC1S5	chr6:8013973-8013974(-) m6A 3'UTR       24981863//27773535 chr6:8014111-8014112(-) m6A 3'UTR       24981863//27773535//22608085 chr6:8014180-8014181(-) m6A 3'UTR       24981863//27773535//22608085 chr6:8014429-8014430(-) m6A 3'UTR       24981863//27773535//22608085 chr6:8014471-8014472(-) m6A 3'UTR       24981863//27773535//22608085 chr6:8014498-8014499(-) m6A 3'UTR       25456834//24981863//27773535//22608085 chr6:8014533-8014534(-) m6A 3'UTR       25456834//24981863//22608085 chr6:8014602-8014603(-) m6A 3'UTR       24981863//22608085 chr6:8015564-8015565(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr6:8015577-8015578(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr6:8015809-8015810(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr6:8015823-8015824(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr6:8015856-8015857(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:8015872-8015873(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:8015878-8015879(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:8015906-8015907(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:8015929-8015930(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:8016008-8016009(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr6:8016028-8016029(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr6:8018050-8018051(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr6:8026614-8026615(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27773536//22608085 chr6:8026629-8026630(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27773536//22608085 chr6:8041397-8041398(-) m6A 3'UTR//CDS//exon       27773535 chr6:8041409-8041410(-) m6A 3'UTR//CDS//exon       27773535 chr6:8041432-8041433(-) m6A 3'UTR//CDS//exon       27773535 chr6:8041440-8041441(-) m6A 3'UTR//CDS//exon       27773535 chr6:8041454-8041455(-) m6A 3'UTR//CDS//exon       27773535 chr6:8064538-8064539(-) m6A CDS       24981863 chr6:8064587-8064588(-) m6A CDS       24981863 chr6:8064593-8064594(-) m6A CDS       24981863 chr6:8064618-8064619(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	BLOC1S5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: BLOC1S5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).