Detail Information

Basic Information:


  VIRBase ID:  

HHID00008583

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           SAV1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p SAV1
miRBase
Accession/Entrez ID		 MIMAT0004512 60485
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SAV//WW45//WWP4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SAV1
chr14:51101242(-) A-I      3'UTR
chr14:51122601(-) A-I      intronic
chr14:51117664(-) A-I      intronic
chr14:51122281(-) A-I      intronic
chr14:51122241(-) A-I      intronic
chr14:51101264(-) A-I      3'UTR
chr14:51101247(-) A-I      3'UTR
chr14:51122174(-) A-I      intronic
chr14:51101244(-) A-I      3'UTR
chr14:51101239(-) A-I      3'UTR
chr14:51127438(-) A-I      intronic
chr14:51120504(-) A-I      intronic
chr14:51101235(-) A-I      3'UTR
chr14:51123946(-) A-I      intronic
chr14:51123954(-) A-I      intronic
chr14:51123956(-) A-I      intronic
chr14:51123957(-) A-I      intronic
chr14:51123972(-) A-I      intronic
chr14:51123868(-) A-I      intronic
chr14:51123885(-) A-I      intronic
chr14:51123864(-) A-I      intronic
chr14:51120475(-) A-I      intronic
chr14:51123980(-) A-I      intronic
chr14:51129122(-) A-I      intronic
chr14:51122719(-) A-I      intronic
chr14:51129114(-) A-I      intronic
chr14:51123985(-) A-I      intronic
chr14:51126469(-) A-I      intronic
chr14:51120511(-) A-I      intronic
chr14:51122750(-) A-I      intronic
chr14:51118485(-) A-I      intronic
chr14:51118639(-) A-I      intronic
chr14:51126356(-) A-I      intronic
chr14:51129090(-) A-I      intronic
chr14:51123433(-) A-I      intronic
chr14:51122615(-) A-I      intronic
chr14:51126481(-) A-I      intronic
chr14:51118380(-) A-I      intronic
chr14:51102363(-) A-I      intronic
chr14:51122304(-) A-I      intronic
chr14:51122311(-) A-I      intronic
chr14:51122317(-) A-I      intronic
chr14:51118417(-) A-I      intronic
chr14:51122322(-) A-I      intronic
chr14:51123237(-) A-I      intronic
chr14:51122323(-) A-I      intronic
chr14:51126424(-) A-I      intronic
chr14:51123276(-) A-I      intronic
chr14:51122272(-) A-I      intronic
chr14:51123321(-) A-I      intronic
chr14:51122760(-) A-I      intronic
chr14:51102697(-) A-I      intronic
chr14:51122663(-) A-I      intronic
chr14:51123325(-) A-I      intronic
chr14:51122337(-) A-I      intronic
chr14:51126442(-) A-I      intronic
chr14:51122435(-) A-I      intronic
chr14:51123891(-) A-I      intronic
chr14:51126452(-) A-I      intronic
chr14:51122737(-) A-I      intronic
chr14:51123917(-) A-I      intronic
chr14:51101336(-) A-I      3'UTR
chr14:51101177(-) A-I      3'UTR
chr14:51101341(-) A-I      3'UTR
chr14:51101152(-) A-I      3'UTR
chr14:51101257(-) A-I      3'UTR
chr14:51101251(-) A-I      3'UTR
chr14:51101158(-) A-I      3'UTR
chr14:51101205(-) A-I      3'UTR
chr14:51101287(-) A-I      3'UTR
chr14:51118548(-) A-I      intronic
chr14:51102289(-) A-I      intronic
chr14:51126560(-) A-I      intronic
chr14:51122680(-) A-I      intronic
chr14:51122703(-) A-I      intronic
chr14:51122282(-) A-I      intronic
chr14:51122509(-) A-I      intronic
chr14:51122300(-) A-I      intronic
chr14:51122651(-) A-I      intronic
chr14:51126400(-) A-I      intronic
chr14:51122390(-) A-I      intronic
chr14:51122433(-) A-I      intronic
chr14:51122724(-) A-I      intronic
chr14:51105624(-) A-I      intronic
chr14:51118622(-) A-I      intronic
chr14:51122491(-) A-I      intronic
chr14:51126406(-) A-I      intronic
chr14:51122394(-) A-I      intronic
chr14:51122598(-) A-I      intronic
chr14:51126521(-) A-I      intronic
chr14:51119639(-) A-I      intronic
chr14:51119666(-) A-I      intronic
chr14:51126556(-) A-I      intronic
chr14:51126478(-) A-I      intronic
chr14:51123802(-) A-I      intronic
chr14:51122641(-) A-I      intronic
chr14:51122762(-) A-I      intronic
chr14:51122240(-) A-I      intronic
chr14:51122395(-) A-I      intronic
chr14:51123813(-) A-I      intronic
chr14:51107110(-) A-I      intronic
chr14:51123890(-) A-I      intronic
chr14:51122220(-) A-I      intronic
chr14:51122347(-) A-I      intronic
chr14:51101263(-) A-I      3'UTR
chr14:51101231(-) A-I      3'UTR
chr14:51101288(-) A-I      3'UTR
chr14:51101136(-) A-I      3'UTR
chr14:51101272(-) A-I      3'UTR
chr14:51101223(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SAV1
chr14:51101272(-) A-G exon 3'UTR    22484847
chr14:51118639(-) A-G intron -    22484847
chr14:51126424(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SAV1
chr14:51100810-51100811(-) m6A 3'UTR       27773535
chr14:51100927-51100928(-) m6A 3'UTR//intron       27773535
chr14:51101056-51101057(-) m6A 3'UTR//intron       24981863
chr14:51101092-51101093(-) m6A 3'UTR//intron       24981863
chr14:51101833-51101834(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:51101939-51101940(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr14:51101952-51101953(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr14:51101978-51101979(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr14:51107561-51107562(-) m6A CDS//intron       27773535
chr14:51111519-51111520(-) m6A CDS//intron       24981863//27773535//22608085
chr14:51111562-51111563(-) m6A CDS//intron       24981863//22608085
chr14:51111639-51111640(-) m6A CDS//intron       27773535//22608085
chr14:51111644-51111645(-) m6A CDS//intron       27773535//22608085
chr14:51129285-51129286(-) m6A intron       27773535
chr14:51129345-51129346(-) m6A intron       27773535
chr14:51129695-51129696(-) m6A intron       25456834//24981863//27773535//27371828//22608085
chr14:51129721-51129722(-) m6A intron       25456834//24981863//27773535//27371828//22608085
chr14:51129740-51129741(-) m6A intron       25456834//24981863//27773535//27371828//22608085
chr14:51129782-51129783(-) m6A intron       27773535
chr14:51131483-51131484(-) m6A exon//intron       24981863
chr14:51131509-51131510(-) m6A exon//intron       24981863
chr14:51131520-51131521(-) m6A exon//intron       24981863
chr14:51131542-51131543(-) m6A exon//intron       24981863
chr14:51131805-51131806(-) m6A exon//intron       24981863
chr14:51131811-51131812(-) m6A exon//intron       24981863
chr14:51131967-51131968(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132021-51132022(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132048-51132049(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:51132190-51132191(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:51132205-51132206(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132222-51132223(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51132289-51132290(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:51134108-51134109(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr14:51134148-51134149(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr14:51134188-51134189(-) m6A CDS//intron       24209618//27773535
chr14:51134615-51134616(-) m1A CDS       26863196
chr14:51134666-51134667(-) m6A CDS       24209618//24981863//27773536
chr14:51134820-51134821(-) m6A 5'UTR       24209618//27371828//27773536
chr14:51134857-51134858(-) m6A 5'UTR       24209618//27371828//27773536
chr14:51134901-51134902(-) m6A 5'UTR       24209618//24981863//27371828//27773536
chr14:51134991-51134992(-) m6A 5'UTR       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
SAV1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: SAV1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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