Detail Information

Basic Information:


  VIRBase ID:  

HHID00008562

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           FEM1C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p FEM1C
miRBase
Accession/Entrez ID		 MIMAT0004512 56929
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EUROIMAGE686608//EUROIMAGE783647//FEM1A

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FEM1C
chr5:114856756-114856757(-) m6A 3'UTR       27773535
chr5:114856829-114856830(-) m6A 3'UTR       27773535
chr5:114856862-114856863(-) m6A 3'UTR       27773535
chr5:114858758-114858759(-) m6A 3'UTR       27773535
chr5:114859517-114859518(-) m6A 3'UTR       27773535
chr5:114859526-114859527(-) m6A 3'UTR       27773535
chr5:114859546-114859547(-) m6A 3'UTR       27773535
chr5:114860027-114860028(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:114860175-114860176(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860185-114860186(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860233-114860234(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:114860284-114860285(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:114860386-114860387(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860456-114860457(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860473-114860474(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860478-114860479(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860577-114860578(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860694-114860695(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:114860809-114860810(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:114860950-114860951(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:114860987-114860988(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861000-114861001(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861017-114861018(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861037-114861038(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861088-114861089(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861134-114861135(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861143-114861144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:114861271-114861272(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:114878710-114878711(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr5:114878753-114878754(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr5:114878779-114878780(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr5:114878908-114878909(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr5:114878952-114878953(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:114879075-114879076(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:114879145-114879146(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:114879177-114879178(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:114879195-114879196(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:114879243-114879244(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:114879284-114879285(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:114879336-114879337(-) m6A 5'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:114880234-114880235(-) m6A 5'UTR       24284625//24209618//24981863//27371828//27773536//22608085
chr5:114880267-114880268(-) m6A 5'UTR       24284625//24209618//24981863//27371828//27773536
chr5:114880294-114880295(-) m6A 5'UTR       24284625//24209618//24981863//27371828//27773536
chr5:114880385-114880386(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
FEM1C
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: FEM1C

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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