Basic Information:

  VIRBase ID:  

HHID00008543

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          TMEM184C:  NM_018241     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	TMEM184C
miRBase Accession/Entrez ID	MIMAT0004512	55751
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM34

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM184C	chr4:148548618(+) A-I      intronic chr4:148548567(+) A-I      intronic chr4:148548546(+) A-I      intronic chr4:148548535(+) A-I      intronic chr4:148548521(+) A-I      intronic chr4:148548490(+) A-I      intronic chr4:148544575(+) A-I      intronic chr4:148544573(+) A-I      intronic chr4:148544556(+) A-I      intronic chr4:148544436(+) A-I      intronic chr4:148563002(+) A-I      intronic chr4:148543966(+) A-I      intronic chr4:148563051(+) A-I      intronic chr4:148563490(+) A-I      intronic chr4:148564234(+) A-I      intronic chr4:148564227(+) A-I      intronic chr4:148564172(+) A-I      intronic chr4:148563575(+) A-I      intronic chr4:148563502(+) A-I      intronic chr4:148564235(+) A-I      intronic chr4:148543936(+) A-I      intronic chr4:148564240(+) A-I      intronic chr4:148544422(+) A-I      intronic chr4:148564344(+) A-I      intronic chr4:148565014(+) A-I      intronic chr4:148562917(+) A-I      intronic chr4:148564359(+) A-I      intronic chr4:148572132(+) A-I      intronic chr4:148572142(+) A-I      intronic chr4:148564364(+) A-I      intronic chr4:148562939(+) A-I      intronic chr4:148562942(+) A-I      intronic chr4:148562979(+) A-I      intronic chr4:148565000(+) A-I      intronic chr4:148564996(+) A-I      intronic chr4:148564967(+) A-I      intronic chr4:148564960(+) A-I      intronic chr4:148564888(+) A-I      intronic chr4:148564367(+) A-I      intronic chr4:148563027(+) A-I      intronic chr4:148563035(+) A-I      intronic chr4:148564338(+) A-I      intronic chr4:148562913(+) A-I      intronic chr4:148562111(+) A-I      intronic chr4:148562925(+) A-I      intronic chr4:148562103(+) A-I      intronic chr4:148549235(+) A-I      intronic chr4:148548748(+) A-I      intronic chr4:148556061(+) A-I      3'UTR chr4:148556017(+) A-I      3'UTR chr4:148556019(+) A-I      3'UTR chr4:148556058(+) A-I      3'UTR chr4:148570793(+) A-I      intronic chr4:148549254(+) A-I      intronic chr4:148548495(+) A-I      intronic chr4:148570710(+) A-I      intronic chr4:148554631(+) A-I      intronic chr4:148549199(+) A-I      intronic chr4:148570843(+) A-I      intronic chr4:148553312(+) A-I      intronic chr4:148544876(+) A-I      intronic chr4:148556007(+) A-I      3'UTR chr4:148556135(+) A-I      3'UTR chr4:148556134(+) A-I      3'UTR chr4:148556147(+) A-I      3'UTR chr4:148555893(+) A-I      3'UTR chr4:148549036(+) A-I      intronic chr4:148553075(+) A-I      intronic chr4:148570779(+) A-I      intronic chr4:148549289(+) A-I      intronic chr4:148570728(+) A-I      intronic chr4:148564161(+) A-I      intronic chr4:148564964(+) A-I      intronic chr4:148549167(+) A-I      intronic chr4:148544017(+) A-I      intronic chr4:148553076(+) A-I      intronic chr4:148570930(+) A-I      intronic chr4:148543222(+) A-I      intronic chr4:148543258(+) A-I      intronic chr4:148570876(+) A-I      intronic chr4:148570771(+) A-I      intronic chr4:148570718(+) A-I      intronic chr4:148553308(+) A-I      intronic chr4:148548635(+) A-I      intronic chr4:148554657(+) A-I      intronic chr4:148553191(+) A-I      intronic chr4:148554563(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM184C	chr4:148544876(+) A-G intron -    22484847 chr4:148548481(+) A-G intron -    22484847 chr4:148548545(+) A-G intron -    22484847 chr4:148549296(+) T-C intron -    22484847 chr4:148554657(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM184C	chr4:148538709-148538710(+) m6A 5'UTR       - chr4:148538714-148538715(+) m6A 5'UTR       22575960 chr4:148538944-148538945(+) m6A 5'UTR       24284625//24981863 chr4:148539027-148539028(+) m6A 5'UTR       24284625 chr4:148539038-148539039(+) m6A 5'UTR       24284625 chr4:148539105-148539106(+) m6A 5'UTR       24284625//24981863 chr4:148555380-148555381(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr4:148555473-148555474(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555492-148555493(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555557-148555558(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555585-148555586(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555602-148555603(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:148555659-148555660(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr4:148555774-148555775(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr4:148555780-148555781(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr4:148555823-148555824(+) m6A 3'UTR//intron       22608085 chr4:148555877-148555878(+) m6A 3'UTR//intron       22608085 chr4:148555894-148555895(+) m6A 3'UTR//intron       22608085 chr4:148556064-148556065(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148556180-148556181(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:148556195-148556196(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:148556279-148556280(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr4:148556313-148556314(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr4:148556844-148556845(+) m6A 3'UTR//intron       27773535 chr4:148556858-148556859(+) m6A 3'UTR//intron       27773535 chr4:148556864-148556865(+) m6A 3'UTR//intron       27773535 chr4:148556882-148556883(+) m6A 3'UTR//intron       27773535 chr4:148556922-148556923(+) m6A 3'UTR//intron       27773535 chr4:148557114-148557115(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557122-148557123(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557139-148557140(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557266-148557267(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557305-148557306(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557347-148557348(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557382-148557383(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557397-148557398(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557419-148557420(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557440-148557441(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557470-148557471(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557500-148557501(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557511-148557512(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557527-148557528(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557567-148557568(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557587-148557588(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557600-148557601(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557613-148557614(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557647-148557648(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557660-148557661(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557667-148557668(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557680-148557681(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557701-148557702(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:148557758-148557759(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557764-148557765(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557783-148557784(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557810-148557811(+) m6A 3'UTR//intron       24981863//22608085 chr4:148557827-148557828(+) m6A 3'UTR//intron       24981863//22608085 chr4:148593031-148593032(+) m6A 3'UTR       24981863//22608085 chr4:148593066-148593067(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TMEM184C	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: TMEM184C

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).