Basic Information:

  VIRBase ID:  

HHID00008523

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          EXD2:  NR_034164     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	EXD2
miRBase Accession/Entrez ID	MIMAT0004512	55218
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf114//EXDL2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EXD2	chr14:69661273(+) A-I      intronic chr14:69671103(+) A-I      intronic chr14:69671135(+) A-I      intronic chr14:69671086(+) A-I      intronic chr14:69671077(+) A-I      intronic chr14:69673266(+) A-I      intronic chr14:69667680(+) A-I      intronic chr14:69661098(+) A-I      intronic chr14:69661781(+) A-I      intronic chr14:69661813(+) A-I      intronic chr14:69661965(+) A-I      intronic chr14:69662097(+) A-I      intronic chr14:69662111(+) A-I      intronic chr14:69662157(+) A-I      intronic chr14:69662204(+) A-I      intronic chr14:69667711(+) A-I      intronic chr14:69668419(+) A-I      intronic chr14:69668517(+) A-I      intronic chr14:69671031(+) A-I      intronic chr14:69671058(+) A-I      intronic chr14:69671072(+) A-I      intronic chr14:69672793(+) A-I      intronic chr14:69673258(+) A-I      intronic chr14:69670067(+) A-I      intronic chr14:69673419(+) A-I      intronic chr14:69674010(+) A-I      intronic chr14:69674117(+) A-I      intronic chr14:69674132(+) A-I      intronic chr14:69674858(+) A-I      intronic chr14:69674889(+) A-I      intronic chr14:69674967(+) A-I      intronic chr14:69675207(+) A-I      intronic chr14:69681818(+) A-I      intronic chr14:69681819(+) A-I      intronic chr14:69687488(+) A-I      intronic chr14:69687536(+) A-I      intronic chr14:69687709(+) A-I      intronic chr14:69687713(+) A-I      intronic chr14:69688684(+) A-I      intronic chr14:69688685(+) A-I      intronic chr14:69690838(+) A-I      intronic chr14:69690845(+) A-I      intronic chr14:69690881(+) A-I      intronic chr14:69691562(+) A-I      intronic chr14:69691677(+) A-I      intronic chr14:69694287(+) A-I      intronic chr14:69694336(+) A-I      intronic chr14:69694414(+) A-I      intronic chr14:69700641(+) A-I      intronic chr14:69671091(+) A-I      intronic chr14:69668565(+) A-I      intronic chr14:69671181(+) A-I      intronic chr14:69690864(+) A-I      intronic chr14:69674050(+) A-I      intronic chr14:69673955(+) A-I      intronic chr14:69670054(+) A-I      intronic chr14:69667305(+) A-I      intronic chr14:69670007(+) A-I      intronic chr14:69688754(+) A-I      intronic chr14:69671149(+) A-I      intronic chr14:69673234(+) A-I      intronic chr14:69673434(+) A-I      intronic chr14:69678837(+) A-I      intronic chr14:69668642(+) A-I      intronic chr14:69675134(+) A-I      intronic chr14:69671177(+) A-I      intronic chr14:69671105(+) A-I      intronic chr14:69668753(+) A-I      intronic chr14:69674001(+) A-I      intronic chr14:69668580(+) A-I      intronic chr14:69667723(+) A-I      intronic chr14:69671244(+) A-I      intronic chr14:69668602(+) A-I      intronic chr14:69667670(+) A-I      intronic chr14:69661264(+) A-I      intronic chr14:69668464(+) A-I      intronic chr14:69669875(+) A-I      intronic chr14:69687723(+) A-I      intronic chr14:69672816(+) A-I      intronic chr14:69672657(+) A-I      intronic chr14:69674064(+) A-I      intronic chr14:69678932(+) A-I      intronic chr14:69674123(+) A-I      intronic chr14:69669893(+) A-I      intronic chr14:69662040(+) A-I      intronic chr14:69672858(+) A-I      intronic chr14:69705572(+) A-I      intronic chr14:69680439(+) A-I      intronic chr14:69671049(+) A-I      intronic chr14:69673396(+) A-I      intronic chr14:69662176(+) A-I      intronic chr14:69672900(+) A-I      intronic chr14:69675109(+) A-I      intronic chr14:69674009(+) A-I      intronic chr14:69667327(+) A-I      intronic chr14:69675069(+) A-I      intronic chr14:69671184(+) A-I      intronic chr14:69665863(+) A-I      intronic chr14:69668583(+) A-I      intronic chr14:69672015(+) A-I      intronic chr14:69668783(+) A-I      intronic chr14:69671025(+) A-I      intronic chr14:69673371(+) A-I      intronic chr14:69667223(+) A-I      intronic chr14:69668752(+) A-I      intronic chr14:69673949(+) A-I      intronic chr14:69669869(+) A-I      intronic chr14:69670031(+) A-I      intronic chr14:69673309(+) A-I      intronic chr14:69671136(+) A-I      intronic chr14:69673283(+) A-I      intronic chr14:69667155(+) A-I      intronic chr14:69672912(+) A-I      intronic chr14:69662149(+) A-I      intronic chr14:69669845(+) A-I      intronic chr14:69667937(+) A-I      intronic chr14:69674126(+) A-I      intronic chr14:69673408(+) A-I      intronic chr14:69668933(+) A-I      intronic chr14:69674796(+) A-I      intronic chr14:69665703(+) A-I      intronic chr14:69672847(+) A-I      intronic chr14:69679333(+) A-I      intronic chr14:69673420(+) A-I      intronic chr14:69667780(+) A-I      intronic chr14:69679351(+) A-I      intronic chr14:69668186(+) A-I      intronic chr14:69668673(+) A-I      intronic chr14:69673427(+) A-I      intronic chr14:69673956(+) A-I      intronic chr14:69674136(+) A-I      intronic chr14:69671202(+) A-I      intronic chr14:69673296(+) A-I      intronic chr14:69662032(+) A-I      intronic chr14:69688662(+) A-I      intronic chr14:69673264(+) A-I      intronic chr14:69674049(+) A-I      intronic chr14:69661129(+) A-I      intronic chr14:69673338(+) A-I      intronic chr14:69673324(+) A-I      intronic chr14:69668832(+) A-I      intronic chr14:69668982(+) A-I      intronic chr14:69671191(+) A-I      intronic chr14:69669078(+) A-I      intronic chr14:69671137(+) A-I      intronic chr14:69674166(+) A-I      intronic chr14:69669843(+) A-I      intronic chr14:69668574(+) A-I      intronic chr14:69669905(+) A-I      intronic chr14:69670003(+) A-I      intronic chr14:69674156(+) A-I      intronic chr14:69671029(+) A-I      intronic chr14:69673297(+) A-I      intronic chr14:69668943(+) A-I      intronic chr14:69668597(+) A-I      intronic chr14:69669020(+) A-I      intronic chr14:69674052(+) A-I      intronic chr14:69668103(+) A-I      intronic chr14:69672729(+) A-I      intronic chr14:69668072(+) A-I      intronic chr14:69662054(+) A-I      intronic chr14:69673461(+) A-I      intronic chr14:69688280(+) A-I      intronic chr14:69661725(+) A-I      intronic chr14:69679335(+) A-I      intronic chr14:69673473(+) A-I      intronic chr14:69688386(+) A-I      intronic chr14:69661117(+) A-I      intronic chr14:69687860(+) A-I      intronic chr14:69671951(+) A-I      intronic chr14:69667779(+) A-I      intronic chr14:69674051(+) A-I      intronic chr14:69694399(+) A-I      intronic chr14:69668529(+) A-I      intronic chr14:69694465(+) A-I      intronic chr14:69668071(+) A-I      intronic chr14:69667726(+) A-I      intronic chr14:69673479(+) A-I      intronic chr14:69663410(+) A-I      intronic chr14:69671138(+) A-I      intronic chr14:69687653(+) A-I      intronic chr14:69667615(+) A-I      intronic chr14:69670028(+) A-I      intronic chr14:69669077(+) A-I      intronic chr14:69665850(+) A-I      intronic chr14:69668928(+) A-I      intronic chr14:69674799(+) A-I      intronic chr14:69662175(+) A-I      intronic chr14:69668126(+) A-I      intronic chr14:69674090(+) A-I      intronic chr14:69674821(+) A-I      intronic chr14:69672839(+) A-I      intronic chr14:69662177(+) A-I      intronic chr14:69667191(+) A-I      intronic chr14:69663372(+) A-I      intronic chr14:69667163(+) A-I      intronic chr14:69674032(+) A-I      intronic chr14:69708020(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EXD2	chr14:69708020(+) A-I exon 3'UTR    19478186 chr14:69673955(+) A-I intron -    22327324 chr14:69671953(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EXD2	chr14:69658301-69658302(+) m6A 5'UTR//exon       24981863 chr14:69676195-69676196(+) m6A 5'UTR//CDS//exon//intron       24981863//22608085 chr14:69676200-69676201(+) m6A 5'UTR//CDS//exon//intron       24981863//22608085 chr14:69701699-69701700(+) m6A CDS//exon       24981863 chr14:69701709-69701710(+) m6A CDS//exon       24981863 chr14:69707713-69707714(+) m6A CDS//exon       24284625//24981863//22608085 chr14:69707755-69707756(+) m6A CDS//exon       24284625//24981863//22608085 chr14:69707840-69707841(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr14:69707943-69707944(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr14:69708047-69708048(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708142-69708143(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708271-69708272(+) m6A 3'UTR//exon       24284625 chr14:69708425-69708426(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708430-69708431(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708486-69708487(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708519-69708520(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708526-69708527(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708544-69708545(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:69708615-69708616(+) m6A 3'UTR//exon       24284625//22608085 chr14:69708778-69708779(+) m6A 3'UTR//exon       24981863 chr14:69708805-69708806(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	EXD2	Chromatin K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: EXD2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).