Basic Information:

  VIRBase ID:  

HHID00008512

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          HEATR3:  NM_182922     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	HEATR3
miRBase Accession/Entrez ID	MIMAT0004512	55027
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SYO1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HEATR3	chr16:50137248(+) A-I      intronic chr16:50139742(+) A-I      3'UTR chr16:50139817(+) A-I      3'UTR chr16:50124190(+) A-I      intronic chr16:50124225(+) A-I      intronic chr16:50124245(+) A-I      intronic chr16:50133559(+) A-I      intronic chr16:50136854(+) A-I      intronic chr16:50138059(+) A-I      intronic chr16:50123638(+) A-I      intronic chr16:50116755(+) A-I      intronic chr16:50116631(+) A-I      intronic chr16:50116623(+) A-I      intronic chr16:50115180(+) A-I      intronic chr16:50115096(+) A-I      intronic chr16:50115095(+) A-I      intronic chr16:50114355(+) A-I      intronic chr16:50129238(+) A-I      intronic chr16:50129094(+) A-I      intronic chr16:50126097(+) A-I      intronic chr16:50101159(+) A-I      intronic chr16:50101177(+) A-I      intronic chr16:50109101(+) A-I      intronic chr16:50108842(+) A-I      intronic chr16:50101194(+) A-I      intronic chr16:50132293(+) A-I      intronic chr16:50133553(+) A-I      intronic chr16:50129252(+) A-I      intronic chr16:50124168(+) A-I      intronic chr16:50124247(+) A-I      intronic chr16:50114345(+) A-I      intronic chr16:50124158(+) A-I      intronic chr16:50102239(+) A-I      intronic chr16:50108417(+) A-I      intronic chr16:50108436(+) A-I      intronic chr16:50108632(+) A-I      intronic chr16:50108639(+) A-I      intronic chr16:50108805(+) A-I      intronic chr16:50108818(+) A-I      intronic chr16:50108834(+) A-I      intronic chr16:50138221(+) A-I      intronic chr16:50139148(+) A-I      3'UTR chr16:50139711(+) A-I      3'UTR chr16:50139131(+) A-I      3'UTR chr16:50139175(+) A-I      3'UTR chr16:50139305(+) A-I      3'UTR chr16:50139679(+) A-I      3'UTR chr16:50108625(+) A-I      intronic chr16:50116107(+) A-I      intronic chr16:50115149(+) A-I      intronic chr16:50114296(+) A-I      intronic chr16:50108315(+) A-I      intronic chr16:50129511(+) A-I      intronic chr16:50101055(+) A-I      intronic chr16:50108531(+) A-I      intronic chr16:50133538(+) A-I      intronic chr16:50138265(+) A-I      intronic chr16:50123660(+) A-I      intronic chr16:50115093(+) A-I      intronic chr16:50108525(+) A-I      intronic chr16:50116051(+) A-I      intronic chr16:50124121(+) A-I      intronic chr16:50109085(+) A-I      intronic chr16:50114471(+) A-I      intronic chr16:50108328(+) A-I      intronic chr16:50108877(+) A-I      intronic chr16:50109107(+) A-I      intronic chr16:50102325(+) A-I      intronic chr16:50108709(+) A-I      intronic chr16:50109066(+) A-I      intronic chr16:50101168(+) A-I      intronic chr16:50102280(+) A-I      intronic chr16:50137681(+) A-I      intronic chr16:50108368(+) A-I      intronic chr16:50101009(+) A-I      intronic chr16:50139262(+) A-I      3'UTR chr16:50139758(+) A-I      3'UTR chr16:50139293(+) A-I      3'UTR chr16:50139180(+) A-I      3'UTR chr16:50139258(+) A-I      3'UTR chr16:50139702(+) A-I      3'UTR chr16:50139762(+) A-I      3'UTR chr16:50139328(+) A-I      3'UTR chr16:50139765(+) A-I      3'UTR chr16:50139556(+) A-I      3'UTR chr16:50139279(+) A-I      3'UTR chr16:50139219(+) A-I      3'UTR chr16:50139294(+) A-I      3'UTR chr16:50139242(+) A-I      3'UTR chr16:50139744(+) A-I      3'UTR chr16:50111047(+) A-I      intronic chr16:50123680(+) A-I      intronic chr16:50132492(+) A-I      intronic chr16:50124206(+) A-I      intronic chr16:50102235(+) A-I      intronic chr16:50136700(+) A-I      intronic chr16:50133238(+) A-I      intronic chr16:50133583(+) A-I      intronic chr16:50123633(+) A-I      intronic chr16:50114617(+) A-I      intronic chr16:50133619(+) A-I      intronic chr16:50125594(+) A-I      intronic chr16:50116925(+) A-I      intronic chr16:50138355(+) A-I      intronic chr16:50126136(+) A-I      intronic chr16:50125595(+) A-I      intronic chr16:50132966(+) A-I      intronic chr16:50115150(+) A-I      intronic chr16:50120585(+) A-I      intronic chr16:50109160(+) A-I      intronic chr16:50137930(+) A-I      intronic chr16:50116043(+) A-I      intronic chr16:50136791(+) A-I      intronic chr16:50108377(+) A-I      intronic chr16:50116782(+) A-I      intronic chr16:50108431(+) A-I      intronic chr16:50138129(+) A-I      intronic chr16:50102302(+) A-I      intronic chr16:50108730(+) A-I      intronic chr16:50108380(+) A-I      intronic chr16:50108751(+) A-I      intronic chr16:50101058(+) A-I      intronic chr16:50136860(+) A-I      intronic chr16:50136705(+) A-I      intronic chr16:50137682(+) A-I      intronic chr16:50114308(+) A-I      intronic chr16:50109068(+) A-I      intronic chr16:50108412(+) A-I      intronic chr16:50124057(+) A-I      intronic chr16:50137838(+) A-I      intronic chr16:50101064(+) A-I      intronic chr16:50124125(+) A-I      intronic chr16:50101146(+) A-I      intronic chr16:50137918(+) A-I      intronic chr16:50108638(+) A-I      intronic chr16:50138376(+) A-I      intronic chr16:50109169(+) A-I      intronic chr16:50124210(+) A-I      intronic chr16:50125267(+) A-I      intronic chr16:50136936(+) A-I      intronic chr16:50115271(+) A-I      intronic chr16:50108732(+) A-I      intronic chr16:50123679(+) A-I      intronic chr16:50114438(+) A-I      intronic chr16:50138325(+) A-I      intronic chr16:50123697(+) A-I      intronic chr16:50108772(+) A-I      intronic chr16:50129578(+) A-I      intronic chr16:50136799(+) A-I      intronic chr16:50126627(+) A-I      intronic chr16:50108321(+) A-I      intronic chr16:50102313(+) A-I      intronic chr16:50108290(+) A-I      intronic chr16:50114356(+) A-I      intronic chr16:50126537(+) A-I      intronic chr16:50136778(+) A-I      intronic chr16:50132446(+) A-I      intronic chr16:50133590(+) A-I      intronic chr16:50138326(+) A-I      intronic chr16:50126116(+) A-I      intronic chr16:50116766(+) A-I      intronic chr16:50101036(+) A-I      intronic chr16:50138519(+) A-I      intronic chr16:50115165(+) A-I      intronic chr16:50108727(+) A-I      intronic chr16:50133307(+) A-I      intronic chr16:50102312(+) A-I      intronic chr16:50137168(+) A-I      intronic chr16:50124207(+) A-I      intronic chr16:50103258(+) A-I      intronic chr16:50126559(+) A-I      intronic chr16:50138143(+) A-I      intronic chr16:50108434(+) A-I      intronic chr16:50138457(+) A-I      intronic chr16:50115204(+) A-I      intronic chr16:50124909(+) A-I      intronic chr16:50138501(+) A-I      intronic chr16:50137201(+) A-I      intronic chr16:50124162(+) A-I      intronic chr16:50138458(+) A-I      intronic chr16:50114381(+) A-I      intronic chr16:50139592(+) A-I      3'UTR chr16:50139483(+) A-I      3'UTR chr16:50139542(+) A-I      3'UTR chr16:50139387(+) A-I      3'UTR chr16:50139704(+) A-I      3'UTR chr16:50139717(+) A-I      3'UTR chr16:50139580(+) A-I      3'UTR chr16:50139743(+) A-I      3'UTR chr16:50139156(+) A-I      3'UTR chr16:50139562(+) A-I      3'UTR chr16:50139379(+) A-I      3'UTR chr16:50139703(+) A-I      3'UTR chr16:50139269(+) A-I      3'UTR chr16:50139284(+) A-I      3'UTR chr16:50139140(+) A-I      3'UTR chr16:50139162(+) A-I      3'UTR chr16:50139188(+) A-I      3'UTR chr16:50139573(+) A-I      3'UTR chr16:50139386(+) A-I      3'UTR chr16:50139117(+) A-I      3'UTR chr16:50139185(+) A-I      3'UTR chr16:50139526(+) A-I      3'UTR chr16:50139563(+) A-I      3'UTR chr16:50139139(+) A-I      3'UTR chr16:50139716(+) A-I      3'UTR chr16:50139541(+) A-I      3'UTR chr16:50139517(+) A-I      3'UTR chr16:50139515(+) A-I      3'UTR chr16:50139199(+) A-I      3'UTR chr16:50139691(+) A-I      3'UTR chr16:50139194(+) A-I      3'UTR chr16:50139756(+) A-I      3'UTR chr16:50139275(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HEATR3	chr16:50139117(+) A-I exon 3'UTR    15342557 chr16:50139137(+) A-I exon 3'UTR    15342557   //15258596   //21960545   //22327324 chr16:50139139(+) A-I exon 3'UTR    15258596   //21960545 chr16:50139140(+) A-I exon 3'UTR    15342557   //15258596 chr16:50139194(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr16:50139199(+) A-I exon 3'UTR    15342557 chr16:50139258(+) A-I exon 3'UTR    15342557 chr16:50139262(+) A-I exon 3'UTR    15342557 chr16:50139328(+) A-I exon 3'UTR    15342557 chr16:50139185(+) A-I intron -    22327324 chr16:50139328(+) A-G intron -    21725310   //22484847 chr16:50101036(+) A-G intron -    22484847 chr16:50139140(+) A-G intron -    22484847 chr16:50139185(+) A-G intron -    22484847 chr16:50139194(+) A-G intron -    22484847 chr16:50139294(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HEATR3	chr16:50100132-50100133(+) m6A CDS//exon       24981863 chr16:50112800-50112801(+) m6A CDS       24981863 chr16:50112831-50112832(+) m6A CDS       24981863 chr16:50112905-50112906(+) m6A CDS//exon       24981863 chr16:50138945-50138946(+) m6A CDS       24981863//27773535//22608085 chr16:50138959-50138960(+) m6A CDS       24981863//27773535//22608085 chr16:50138972-50138973(+) m6A 3'UTR       24981863//27773535//22608085 chr16:50138988-50138989(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	HEATR3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: HEATR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).