Detail Information

Basic Information:


  VIRBase ID:  

HHID00008472

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           UCHL5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p UCHL5
miRBase
Accession/Entrez ID		 MIMAT0004512 51377
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-70//INO80R//UCH-L5//UCH37

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UCHL5
chr1:193020025(-) A-I      intronic
chr1:193018250(-) A-I      intronic
chr1:193019793(-) A-I      intronic
chr1:193018461(-) A-I      intronic
chr1:193020047(-) A-I      intronic
chr1:193019671(-) A-I      intronic
chr1:193018444(-) A-I      intronic
chr1:193018074(-) A-I      intronic
chr1:193018481(-) A-I      intronic
chr1:193018151(-) A-I      intronic
chr1:193018428(-) A-I      intronic
chr1:193018538(-) A-I      intronic
chr1:193018147(-) A-I      intronic
chr1:193018501(-) A-I      intronic
chr1:193018602(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UCHL5
chr1:193011064(-) T-C intron -    22484847
chr1:193011244(-) C-T intron -    22484847
chr1:193011245(-) T-C intron -    22484847
chr1:193018428(-) A-G intron -    22484847
chr1:193018538(-) A-G intron -    22484847
chr1:193018602(-) A-G intron -    22484847
chr1:193019671(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UCHL5
chr1:192981391-192981392(-) m6A 3'UTR       27773535
chr1:192981399-192981400(-) m6A 3'UTR       27773535
chr1:192981495-192981496(-) m6A 3'UTR       27773535
chr1:192981615-192981616(-) m6A 3'UTR       27773535
chr1:192981658-192981659(-) m6A 3'UTR       27773535
chr1:192981674-192981675(-) m6A 3'UTR       27773535
chr1:192981717-192981718(-) m6A 3'UTR       27773535
chr1:192981751-192981752(-) m6A 3'UTR       27773535
chr1:192983142-192983143(-) Y 3'UTR       26075521
chr1:192985328-192985329(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:192985410-192985411(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:192985427-192985428(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:192985488-192985489(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr1:192985513-192985514(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr1:192987599-192987600(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr1:192987637-192987638(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr1:192987681-192987682(-) m6A 3'UTR//intron       24981863//27773535
chr1:192987707-192987708(-) m6A 3'UTR//intron       24981863//27773535
chr1:192987718-192987719(-) m6A 3'UTR//intron       24981863//27773535
chr1:192987904-192987905(-) m6A 3'UTR//intron       24981863//27773535
chr1:192987931-192987932(-) m6A 3'UTR//intron       24981863//27773535
chr1:192990256-192990257(-) m6A CDS       24981863//27773535
chr1:192990267-192990268(-) m6A CDS       24981863//27773535
chr1:192992163-192992164(-) m6A CDS       24981863//27773535//22575960
chr1:192992985-192992986(-) m6A CDS       24981863//27773535//22575960
chr1:192997047-192997048(-) m6A CDS//intron       24981863//27773535//22575960
chr1:192998321-192998322(-) m6A CDS       27773535//22575960
chr1:192998351-192998352(-) m6A CDS       27773535//22575960
chr1:193028975-193028976(-) m6A CDS       24284625//25456834//27773536//22608085
chr1:193028984-193028985(-) m6A CDS       24284625//25456834//27773536//22608085
chr1:193029064-193029065(-) m6A CDS       24284625//25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
UCHL5
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: UCHL5

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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