Basic Information:

  VIRBase ID:  

HHID00008438

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          DBNL:  NM_014063     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	DBNL
miRBase Accession/Entrez ID	MIMAT0004512	28988
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ABP1//HIP-55//HIP55//SH3P7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DBNL	chr7:44094946(+) A-I      intronic chr7:44094888(+) A-I      intronic chr7:44094924(+) A-I      intronic chr7:44093813(+) A-I      intronic chr7:44094858(+) A-I      intronic chr7:44094809(+) A-I      intronic chr7:44093866(+) A-I      intronic chr7:44094831(+) A-I      intronic chr7:44093853(+) A-I      intronic chr7:44095052(+) A-I      intronic chr7:44094801(+) A-I      intronic chr7:44093975(+) A-I      intronic chr7:44092088(+) A-I      intronic chr7:44088986(+) A-I      intronic chr7:44092116(+) A-I      intronic chr7:44094027(+) A-I      intronic chr7:44091959(+) A-I      intronic chr7:44094864(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DBNL	chr7:44088619(+) G-A intron -    22484847 chr7:44093866(+) A-G intron -    22484847 chr7:44093921(+) A-G intron -    22484847 chr7:44093931(+) A-G intron -    22484847 chr7:44093975(+) A-G intron -    22484847 chr7:44094001(+) A-G intron -    22484847 chr7:44094027(+) A-G intron -    22484847 chr7:44094801(+) A-G intron -    22484847 chr7:44094831(+) A-G intron -    22484847 chr7:44094864(+) A-G intron -    22484847 chr7:44094947(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DBNL	chr7:44084321-44084322(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr7:44084346-44084347(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr7:44089516-44089517(+) m6A exon//intron       24284625//24981863 chr7:44089780-44089781(+) m6A exon//intron       24209618 chr7:44089899-44089900(+) m6A exon//intron       24209618//24981863 chr7:44089907-44089908(+) m6A exon//intron       24209618//24981863 chr7:44091369-44091370(+) m6A exon//intron       - chr7:44091500-44091501(+) m6A 3'UTR//CDS//exon//intron       24209618 chr7:44091513-44091514(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618 chr7:44096486-44096487(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22575960 chr7:44097398-44097399(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr7:44097435-44097436(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr7:44097656-44097657(+) m6A 3'UTR//exon//intron       24209618 chr7:44097740-44097741(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//22575960 chr7:44098065-44098066(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr7:44098107-44098108(+) m6A exon//intron       24284625//24209618//24981863//22575960 chr7:44098162-44098163(+) m6A exon//intron       24284625//24209618 chr7:44098999-44099000(+) m6A 3'UTR//CDS//exon//intron       24284625 chr7:44100408-44100409(+) m6A 3'UTR//CDS//exon       - chr7:44100548-44100549(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr7:44100592-44100593(+) Y 3'UTR//exon       26075521 chr7:44100615-44100616(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr7:44100660-44100661(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr7:44100737-44100738(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr7:44101140-44101141(+) m6A 3'UTR//exon       24284625 chr7:44101291-44101292(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:44101307-44101308(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr7:44105052-44105053(+) m6A 3'UTR       24981863 chr7:44105102-44105103(+) m6A 3'UTR       24981863 chr7:44105141-44105142(+) m6A 3'UTR       24981863 chr7:44105151-44105152(+) m6A 3'UTR       24981863 chr7:44105638-44105639(+) m6A 3'UTR       - chr7:44105896-44105897(+) m6A 3'UTR       - chr7:44105903-44105904(+) m6A 3'UTR       - chr7:44105949-44105950(+) m6A 3'UTR       - chr7:44105992-44105993(+) m6A 3'UTR       - chr7:44105998-44105999(+) m6A 3'UTR       - chr7:44106047-44106048(+) m6A 3'UTR       24981863 chr7:44106099-44106100(+) m6A 3'UTR       24209618 chr7:44106214-44106215(+) m6A 3'UTR       - chr7:44106228-44106229(+) m6A 3'UTR       - chr7:44106251-44106252(+) m6A 3'UTR       - chr7:44106543-44106544(+) m6A 3'UTR       - chr7:44106573-44106574(+) m6A 3'UTR       - chr7:44106620-44106621(+) m6A 3'UTR       - chr7:44106661-44106662(+) m6A 3'UTR       24981863 chr7:44106702-44106703(+) m6A 3'UTR       24981863 chr7:44106803-44106804(+) m6A 3'UTR       24981863 chr7:44107053-44107054(+) m6A 3'UTR       - chr7:44107062-44107063(+) m6A 3'UTR       - chr7:44107123-44107124(+) m6A 3'UTR       - chr7:44108026-44108027(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108047-44108048(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108069-44108070(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108078-44108079(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108105-44108106(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108173-44108174(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108261-44108262(+) m6A 3'UTR       24284625//24981863//22608085 chr7:44108317-44108318(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108380-44108381(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108388-44108389(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108405-44108406(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108447-44108448(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108462-44108463(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108472-44108473(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108479-44108480(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:44108531-44108532(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr7:44108546-44108547(+) m6A 3'UTR       24209618//24981863//22608085 chr7:44108564-44108565(+) m6A 3'UTR       24209618//24981863//22608085 chr7:44108589-44108590(+) m6A 3'UTR       24981863//22608085 chr7:44108677-44108678(+) m6A 3'UTR       24981863//22608085 chr7:44108743-44108744(+) m6A 3'UTR       24981863//22608085 chr7:44108757-44108758(+) m6A 3'UTR       24981863//22608085 chr7:44108786-44108787(+) m6A 3'UTR       24981863//22608085 chr7:44108806-44108807(+) m6A 3'UTR       24981863//22608085 chr7:44108841-44108842(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	DBNL	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: DBNL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).