Detail Information

Basic Information:


  VIRBase ID:  

HHID00008428

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           TAF5L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p TAF5L
miRBase
Accession/Entrez ID		 MIMAT0004512 27097
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAF65B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TAF5L
chr1:229731939(-) A-I      intronic
chr1:229740843(-) A-I      intronic
chr1:229758897(-) A-I      intronic
chr1:229758574(-) A-I      intronic
chr1:229731799(-) A-I      intronic
chr1:229731550(-) A-I      intronic
chr1:229731852(-) A-I      intronic
chr1:229731551(-) A-I      intronic
chr1:229731886(-) A-I      intronic
chr1:229731803(-) A-I      intronic
chr1:229731945(-) A-I      intronic
chr1:229731926(-) A-I      intronic
chr1:229731851(-) A-I      intronic
chr1:229758630(-) A-I      intronic
chr1:229744740(-) A-I      intronic
chr1:229731912(-) A-I      intronic
chr1:229758899(-) A-I      intronic
chr1:229731938(-) A-I      intronic
chr1:229731764(-) A-I      intronic
chr1:229731969(-) A-I      intronic
chr1:229731687(-) A-I      intronic
chr1:229749043(-) A-I      intronic
chr1:229731899(-) A-I      intronic
chr1:229731685(-) A-I      intronic
chr1:229731524(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TAF5L
chr1:229731912(-) A-G intron -    22484847
chr1:229731926(-) A-G intron -    22484847
chr1:229731945(-) A-G intron -    22484847
chr1:229731969(-) A-G intron -    22484847
chr1:229758899(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TAF5L
chr1:229728979-229728980(-) m6A 3'UTR       24981863//22608085
chr1:229729011-229729012(-) m6A 3'UTR       24981863//22608085
chr1:229729023-229729024(-) m6A 3'UTR       24981863//22608085
chr1:229729062-229729063(-) m6A 3'UTR       24981863//22608085
chr1:229729427-229729428(-) Y 3'UTR       26075521
chr1:229729784-229729785(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:229729855-229729856(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr1:229730020-229730021(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:229730049-229730050(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:229730191-229730192(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730200-229730201(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730221-229730222(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730251-229730252(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:229730281-229730282(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:229730312-229730313(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:229730326-229730327(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730347-229730348(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730437-229730438(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730468-229730469(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730497-229730498(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:229730524-229730525(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:229730541-229730542(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:229730641-229730642(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:229730667-229730668(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:229730725-229730726(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730755-229730756(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229730784-229730785(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:229734954-229734955(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:229735022-229735023(-) m6A 3'UTR//intron       24284625//27773535//22608085
chr1:229735233-229735234(-) m6A 3'UTR//intron       27773535//22608085
chr1:229735331-229735332(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr1:229735448-229735449(-) m6A 3'UTR//intron       24981863
chr1:229735739-229735740(-) m6A 3'UTR//intron       24981863
chr1:229735744-229735745(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr1:229735762-229735763(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr1:229735784-229735785(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr1:229735837-229735838(-) m6A 3'UTR//intron       24981863//22608085
chr1:229735872-229735873(-) m6A 3'UTR//intron       24981863//22608085
chr1:229736292-229736293(-) m6A 3'UTR//intron       24981863
chr1:229736302-229736303(-) m6A 3'UTR//intron       24981863
chr1:229736329-229736330(-) m6A 3'UTR//intron       24981863
chr1:229736380-229736381(-) m6A 3'UTR//intron       24981863//27773535
chr1:229737282-229737283(-) m6A 3'UTR//intron       -
chr1:229737757-229737758(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr1:229737818-229737819(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr1:229737854-229737855(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr1:229737875-229737876(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr1:229738034-229738035(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr1:229738098-229738099(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr1:229738254-229738255(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:229738300-229738301(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:229738404-229738405(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr1:229738470-229738471(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:229738480-229738481(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:229738489-229738490(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:229738584-229738585(-) m6A CDS       24284625//27773535//22608085
chr1:229750117-229750118(-) m6A CDS//exon       24209618
chr1:229750133-229750134(-) m6A CDS//exon       24209618
chr1:229750158-229750159(-) m6A CDS//exon       24209618
chr1:229761717-229761718(-) m6A 5'UTR//exon       24284625//24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TAF5L
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: TAF5L

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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