Basic Information:

  VIRBase ID:  

HHID00008424

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          AP3M1:  NR_135191     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	AP3M1
miRBase Accession/Entrez ID	MIMAT0004512	26985
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AP3M1	chr10:75888176(-) A-I      intronic chr10:75888175(-) A-I      intronic chr10:75888170(-) A-I      intronic chr10:75888162(-) A-I      intronic chr10:75888191(-) A-I      intronic chr10:75888192(-) A-I      intronic chr10:75888190(-) A-I      intronic chr10:75888179(-) A-I      intronic chr10:75903186(-) A-I      intronic chr10:75890957(-) A-I      intronic chr10:75902865(-) A-I      intronic chr10:75889943(-) A-I      intronic chr10:75902864(-) A-I      intronic chr10:75890856(-) A-I      intronic chr10:75902852(-) A-I      intronic chr10:75901760(-) A-I      intronic chr10:75907574(-) A-I      intronic chr10:75901752(-) A-I      intronic chr10:75901608(-) A-I      intronic chr10:75901582(-) A-I      intronic chr10:75893592(-) A-I      intronic chr10:75893580(-) A-I      intronic chr10:75893551(-) A-I      intronic chr10:75893550(-) A-I      intronic chr10:75906943(-) A-I      intronic chr10:75903211(-) A-I      intronic chr10:75888124(-) A-I      intronic chr10:75902990(-) A-I      intronic chr10:75888269(-) A-I      intronic chr10:75890868(-) A-I      intronic chr10:75890748(-) A-I      intronic chr10:75890740(-) A-I      intronic chr10:75890706(-) A-I      intronic chr10:75890374(-) A-I      intronic chr10:75906858(-) A-I      intronic chr10:75892961(-) A-I      intronic chr10:75890259(-) A-I      intronic chr10:75886556(-) A-I      intronic chr10:75901062(-) A-I      intronic chr10:75888210(-) A-I      intronic chr10:75901751(-) A-I      intronic chr10:75907502(-) A-I      intronic chr10:75888174(-) A-I      intronic chr10:75888173(-) A-I      intronic chr10:75888172(-) A-I      intronic chr10:75903236(-) A-I      intronic chr10:75903196(-) A-I      intronic chr10:75892767(-) A-I      intronic chr10:75888167(-) A-I      intronic chr10:75888138(-) A-I      intronic chr10:75888133(-) A-I      intronic chr10:75892223(-) A-I      intronic chr10:75888029(-) A-I      intronic chr10:75887776(-) A-I      intronic chr10:75887718(-) A-I      intronic chr10:75887709(-) A-I      intronic chr10:75906921(-) A-I      intronic chr10:75887696(-) A-I      intronic chr10:75887624(-) A-I      intronic chr10:75887348(-) A-I      intronic chr10:75892908(-) A-I      intronic chr10:75902946(-) A-I      intronic chr10:75887335(-) A-I      intronic chr10:75887334(-) A-I      intronic chr10:75908835(-) A-I      intronic chr10:75887190(-) A-I      intronic chr10:75886589(-) A-I      intronic chr10:75890618(-) A-I      intronic chr10:75903190(-) A-I      intronic chr10:75891508(-) A-I      intronic chr10:75886447(-) A-I      intronic chr10:75908866(-) A-I      intronic chr10:75893207(-) A-I      intronic chr10:75903231(-) A-I      intronic chr10:75903201(-) A-I      intronic chr10:75892204(-) A-I      intronic chr10:75893683(-) A-I      intronic chr10:75891579(-) A-I      intronic chr10:75893069(-) A-I      intronic chr10:75909215(-) A-I      intronic chr10:75887858(-) A-I      intronic chr10:75909212(-) A-I      intronic chr10:75909208(-) A-I      intronic chr10:75908769(-) A-I      intronic chr10:75908763(-) A-I      intronic chr10:75908759(-) A-I      intronic chr10:75908439(-) A-I      intronic chr10:75908742(-) A-I      intronic chr10:75908416(-) A-I      intronic chr10:75908414(-) A-I      intronic chr10:75907716(-) A-I      intronic chr10:75893528(-) A-I      intronic chr10:75893521(-) A-I      intronic chr10:75893519(-) A-I      intronic chr10:75893505(-) A-I      intronic chr10:75907695(-) A-I      intronic chr10:75893315(-) A-I      intronic chr10:75893236(-) A-I      intronic chr10:75893211(-) A-I      intronic chr10:75893210(-) A-I      intronic chr10:75907694(-) A-I      intronic chr10:75893105(-) A-I      intronic chr10:75892940(-) A-I      intronic chr10:75892257(-) A-I      intronic chr10:75892186(-) A-I      intronic chr10:75892068(-) A-I      intronic chr10:75891992(-) A-I      intronic chr10:75891881(-) A-I      intronic chr10:75891872(-) A-I      intronic chr10:75891864(-) A-I      intronic chr10:75891863(-) A-I      intronic chr10:75891856(-) A-I      intronic chr10:75891519(-) A-I      intronic chr10:75907594(-) A-I      intronic chr10:75891518(-) A-I      intronic chr10:75891377(-) A-I      intronic chr10:75891499(-) A-I      intronic chr10:75891096(-) A-I      intronic chr10:75892214(-) A-I      intronic chr10:75880548(-) A-I      3'UTR chr10:75880549(-) A-I      3'UTR chr10:75880527(-) A-I      3'UTR chr10:75880404(-) A-I      3'UTR chr10:75880372(-) A-I      3'UTR chr10:75890487(-) A-I      intronic chr10:75906931(-) A-I      intronic chr10:75890742(-) A-I      intronic chr10:75902888(-) A-I      intronic chr10:75908514(-) A-I      intronic chr10:75893593(-) A-I      intronic chr10:75902997(-) A-I      intronic chr10:75908339(-) A-I      intronic chr10:75889967(-) A-I      intronic chr10:75902952(-) A-I      intronic chr10:75887145(-) A-I      intronic chr10:75890606(-) A-I      intronic chr10:75909227(-) A-I      intronic chr10:75889938(-) A-I      intronic chr10:75890334(-) A-I      intronic chr10:75899486(-) A-I      intronic chr10:75909159(-) A-I      intronic chr10:75891478(-) A-I      intronic chr10:75892401(-) A-I      intronic chr10:75908407(-) A-I      intronic chr10:75891430(-) A-I      intronic chr10:75904138(-) A-I      intronic chr10:75886572(-) A-I      intronic chr10:75890787(-) A-I      intronic chr10:75893257(-) A-I      intronic chr10:75890664(-) A-I      intronic chr10:75891095(-) A-I      intronic chr10:75892277(-) A-I      intronic chr10:75891064(-) A-I      intronic chr10:75892848(-) A-I      intronic chr10:75892069(-) A-I      intronic chr10:75890952(-) A-I      intronic chr10:75888270(-) A-I      intronic chr10:75888149(-) A-I      intronic chr10:75909180(-) A-I      intronic chr10:75893219(-) A-I      intronic chr10:75887775(-) A-I      intronic chr10:75892902(-) A-I      intronic chr10:75890700(-) A-I      intronic chr10:75890783(-) A-I      intronic chr10:75887123(-) A-I      intronic chr10:75891991(-) A-I      intronic chr10:75888120(-) A-I      intronic chr10:75891398(-) A-I      intronic chr10:75909275(-) A-I      intronic chr10:75907012(-) A-I      intronic chr10:75909247(-) A-I      intronic chr10:75892807(-) A-I      intronic chr10:75892192(-) A-I      intronic chr10:75890788(-) A-I      intronic chr10:75904692(-) A-I      intronic chr10:75892205(-) A-I      intronic chr10:75907674(-) A-I      intronic chr10:75890758(-) A-I      intronic chr10:75908703(-) A-I      intronic chr10:75892909(-) A-I      intronic chr10:75890762(-) A-I      intronic chr10:75888263(-) A-I      intronic chr10:75890648(-) A-I      intronic chr10:75908383(-) A-I      intronic chr10:75902883(-) A-I      intronic chr10:75893520(-) A-I      intronic chr10:75903185(-) A-I      intronic chr10:75890770(-) A-I      intronic chr10:75888278(-) A-I      intronic chr10:75890282(-) A-I      intronic chr10:75892377(-) A-I      intronic chr10:75907514(-) A-I      intronic chr10:75893113(-) A-I      intronic chr10:75891184(-) A-I      intronic chr10:75890400(-) A-I      intronic chr10:75891444(-) A-I      intronic chr10:75889905(-) A-I      intronic chr10:75886490(-) A-I      intronic chr10:75892269(-) A-I      intronic chr10:75889965(-) A-I      intronic chr10:75901029(-) A-I      intronic chr10:75908704(-) A-I      intronic chr10:75892332(-) A-I      intronic chr10:75893197(-) A-I      intronic chr10:75908532(-) A-I      intronic chr10:75893004(-) A-I      intronic chr10:75887234(-) A-I      intronic chr10:75891049(-) A-I      intronic chr10:75890447(-) A-I      intronic chr10:75888286(-) A-I      intronic chr10:75893305(-) A-I      intronic chr10:75888574(-) A-I      intronic chr10:75880381(-) A-I      3'UTR chr10:75888345(-) A-I      intronic chr10:75890345(-) A-I      intronic chr10:75909226(-) A-I      intronic chr10:75891496(-) A-I      intronic chr10:75888618(-) A-I      intronic chr10:75891459(-) A-I      intronic chr10:75888477(-) A-I      intronic chr10:75890372(-) A-I      intronic chr10:75888479(-) A-I      intronic chr10:75890699(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AP3M1	chr10:75888120(-) A-G intron -    22484847 chr10:75889943(-) A-G intron -    22484847 chr10:75891496(-) A-G intron -    22484847 chr10:75891508(-) A-G intron -    22484847 chr10:75908703(-) A-G intron -    22484847 chr10:75908704(-) A-G intron -    22484847 chr10:75888618(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AP3M1	chr10:75881899-75881900(-) Y 3'UTR       26075521 chr10:75883544-75883545(-) m6A 3'UTR       26404942 chr10:75883572-75883573(-) m6A CDS       26404942 chr10:75883646-75883647(-) m6A CDS       26404942 chr10:75883655-75883656(-) m6A CDS       26404942 chr10:75884225-75884226(-) m6A CDS       26404942 chr10:75910650-75910651(-) m6A 5'UTR       27773535 chr10:75910765-75910766(-) m6A 5'UTR       24981863//27773535 chr10:75910810-75910811(-) m6A 5'UTR       24981863 chr10:75910817-75910818(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	AP3M1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: AP3M1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).