Detail Information

Basic Information:


  VIRBase ID:  

HHID00008379

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           LARP4B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p LARP4B
miRBase
Accession/Entrez ID		 MIMAT0004512 23185
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - KIAA0217//LARP5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LARP4B
chr10:923234(-) A-I      intronic
chr10:923251(-) A-I      intronic
chr10:923264(-) A-I      intronic
chr10:925535(-) A-I      intronic
chr10:879717(-) A-I      intronic
chr10:881729(-) A-I      intronic
chr10:888310(-) A-I      intronic
chr10:923199(-) A-I      intronic
chr10:923221(-) A-I      intronic
chr10:925718(-) A-I      intronic
chr10:888312(-) A-I      intronic
chr10:909253(-) A-I      intronic
chr10:878184(-) A-I      intronic
chr10:878178(-) A-I      intronic
chr10:909260(-) A-I      intronic
chr10:909450(-) A-I      intronic
chr10:878122(-) A-I      intronic
chr10:881751(-) A-I      intronic
chr10:897742(-) A-I      intronic
chr10:881786(-) A-I      intronic
chr10:881797(-) A-I      intronic
chr10:881654(-) A-I      intronic
chr10:886945(-) A-I      intronic
chr10:879588(-) A-I      intronic
chr10:908605(-) A-I      intronic
chr10:897793(-) A-I      intronic
chr10:887007(-) A-I      intronic
chr10:926585(-) A-I      intronic
chr10:925683(-) A-I      intronic
chr10:908690(-) A-I      intronic
chr10:926478(-) A-I      intronic
chr10:888249(-) A-I      intronic
chr10:925912(-) A-I      intronic
chr10:897350(-) A-I      intronic
chr10:881656(-) A-I      intronic
chr10:925896(-) A-I      intronic
chr10:909240(-) A-I      intronic
chr10:925657(-) A-I      intronic
chr10:928532(-) A-I      intronic
chr10:929339(-) A-I      intronic
chr10:888309(-) A-I      intronic
chr10:897396(-) A-I      intronic
chr10:908532(-) A-I      intronic
chr10:888214(-) A-I      intronic
chr10:926579(-) A-I      intronic
chr10:926544(-) A-I      intronic
chr10:909229(-) A-I      intronic
chr10:888275(-) A-I      intronic
chr10:881710(-) A-I      intronic
chr10:897770(-) A-I      intronic
chr10:925883(-) A-I      intronic
chr10:925605(-) A-I      intronic
chr10:897964(-) A-I      intronic
chr10:925892(-) A-I      intronic
chr10:904982(-) A-I      intronic
chr10:926514(-) A-I      intronic
chr10:887084(-) A-I      intronic
chr10:878220(-) A-I      intronic
chr10:928460(-) A-I      intronic
chr10:899489(-) A-I      intronic
chr10:878217(-) A-I      intronic
chr10:926508(-) A-I      intronic
chr10:925530(-) A-I      intronic
chr10:923209(-) A-I      intronic
chr10:926507(-) A-I      intronic
chr10:879647(-) A-I      intronic
chr10:897919(-) A-I      intronic
chr10:887041(-) A-I      intronic
chr10:926409(-) A-I      intronic
chr10:926498(-) A-I      intronic
chr10:897783(-) A-I      intronic
chr10:886969(-) A-I      intronic
chr10:906713(-) A-I      intronic
chr10:926477(-) A-I      intronic
chr10:926443(-) A-I      intronic
chr10:908578(-) A-I      intronic
chr10:926383(-) A-I      intronic
chr10:908533(-) A-I      intronic
chr10:925882(-) A-I      intronic
chr10:878212(-) A-I      intronic
chr10:926009(-) A-I      intronic
chr10:886999(-) A-I      intronic
chr10:886968(-) A-I      intronic
chr10:878019(-) A-I      intronic
chr10:887012(-) A-I      intronic
chr10:886929(-) A-I      intronic
chr10:926410(-) A-I      intronic
chr10:897818(-) A-I      intronic
chr10:926564(-) A-I      intronic
chr10:886907(-) A-I      intronic
chr10:886835(-) A-I      intronic
chr10:926502(-) A-I      intronic
chr10:889608(-) A-I      intronic
chr10:897838(-) A-I      intronic
chr10:897801(-) A-I      intronic
chr10:886971(-) A-I      intronic
chr10:906907(-) A-I      intronic
chr10:926433(-) A-I      intronic
chr10:928466(-) A-I      intronic
chr10:888307(-) A-I      intronic
chr10:897256(-) A-I      intronic
chr10:887008(-) A-I      intronic
chr10:873214(-) A-I      intronic
chr10:904992(-) A-I      intronic
chr10:878256(-) A-I      intronic
chr10:888339(-) A-I      intronic
chr10:897787(-) A-I      intronic
chr10:909259(-) A-I      intronic
chr10:888276(-) A-I      intronic
chr10:907062(-) A-I      intronic
chr10:897745(-) A-I      intronic
chr10:897397(-) A-I      intronic
chr10:908678(-) A-I      intronic
chr10:926504(-) A-I      intronic
chr10:897897(-) A-I      intronic
chr10:859802(-) A-I      intronic
chr10:879658(-) A-I      intronic
chr10:929269(-) A-I      intronic
chr10:908519(-) A-I      intronic
chr10:879575(-) A-I      intronic
chr10:897898(-) A-I      intronic
chr10:909327(-) A-I      intronic
chr10:888306(-) A-I      intronic
chr10:879587(-) A-I      intronic
chr10:906915(-) A-I      intronic
chr10:879777(-) A-I      intronic
chr10:925878(-) A-I      intronic
chr10:878272(-) A-I      intronic
chr10:926626(-) A-I      intronic
chr10:870322(-) A-I      intronic
chr10:881725(-) A-I      intronic
chr10:888308(-) A-I      intronic
chr10:925852(-) A-I      intronic
chr10:929342(-) A-I      intronic
chr10:886926(-) A-I      intronic
chr10:897361(-) A-I      intronic
chr10:879713(-) A-I      intronic
chr10:926543(-) A-I      intronic
chr10:897235(-) A-I      intronic
chr10:888302(-) A-I      intronic
chr10:923213(-) A-I      intronic
chr10:908613(-) A-I      intronic
chr10:925562(-) A-I      intronic
chr10:888403(-) A-I      intronic
chr10:881690(-) A-I      intronic
chr10:888320(-) A-I      intronic
chr10:897323(-) A-I      intronic
chr10:897924(-) A-I      intronic
chr10:888315(-) A-I      intronic
chr10:897849(-) A-I      intronic
chr10:881724(-) A-I      intronic
chr10:878255(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LARP4B
chr10:878272(-) A-G intron -    22484847
chr10:879587(-) A-G intron -    22484847
chr10:879588(-) A-G intron -    22484847
chr10:879713(-) A-G intron -    22484847
chr10:879777(-) A-G intron -    22484847
chr10:888249(-) A-G intron -    22484847
chr10:888276(-) A-G intron -    22484847
chr10:888302(-) A-G intron -    22484847
chr10:888306(-) A-G intron -    22484847
chr10:888312(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LARP4B
chr10:853092-853093(-) m6A 3'UTR       -
chr10:853099-853100(-) m6A 3'UTR       -
chr10:853116-853117(-) m6A 3'UTR       -
chr10:853163-853164(-) m6A 3'UTR       -
chr10:853254-853255(-) m6A 3'UTR       -
chr10:853403-853404(-) m6A 3'UTR       -
chr10:853463-853464(-) m6A 3'UTR       -
chr10:853474-853475(-) m6A 3'UTR       -
chr10:853695-853696(-) m6A 3'UTR       -
chr10:853728-853729(-) m6A 3'UTR       -
chr10:853782-853783(-) m6A 3'UTR       -
chr10:853794-853795(-) m6A 3'UTR       -
chr10:855538-855539(-) m6A 3'UTR//intron       27773535
chr10:855581-855582(-) m6A 3'UTR//intron       27773535
chr10:855604-855605(-) m6A 3'UTR//intron       27773535
chr10:857629-857630(-) m6A 3'UTR//intron       24981863
chr10:857854-857855(-) Y 3'UTR//exon       26075521
chr10:858304-858305(-) Am 3'UTR//exon//intron       -
chr10:858813-858814(-) m6A 3'UTR//exon//intron       27371828//22575960
chr10:858862-858863(-) m6A 3'UTR//exon       27371828//27773536//22575960//22608085
chr10:858959-858960(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr10:859058-859059(-) m6A CDS//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr10:859069-859070(-) m6A CDS//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr10:860391-860392(-) m6A 3'UTR//exon//intron       24284625//24981863//28052920//27773535//27371828//22608085
chr10:860415-860416(-) m6A 3'UTR//exon//intron       24284625//24981863//27773535//27371828//22608085
chr10:860476-860477(-) m6A CDS//exon//intron       27773535
chr10:860984-860985(-) m6A CDS//exon       27773535
chr10:861009-861010(-) m6A CDS//exon       27773535
chr10:863679-863680(-) m6A CDS//exon       -
chr10:863704-863705(-) m6A CDS//exon       -
chr10:863716-863717(-) m6A CDS//exon       -
chr10:863723-863724(-) m6A CDS//exon       -
chr10:863819-863820(-) m6A CDS//exon       27773535
chr10:863901-863902(-) m6A exon//intron       27773535
chr10:865924-865925(-) m6A exon//intron       27773535
chr10:865936-865937(-) m6A exon//intron       27773535
chr10:866023-866024(-) m6A exon//intron       27773535
chr10:871743-871744(-) Y CDS       26075521
chr10:875474-875475(-) m6A CDS       27773535
chr10:875502-875503(-) m6A CDS       27773535
chr10:875629-875630(-) m6A CDS       27773535
chr10:875643-875644(-) m6A CDS       27773535
chr10:890938-890939(-) m6A CDS       24981863
chr10:890961-890962(-) m6A CDS       24981863
chr10:890973-890974(-) m6A CDS       24981863
chr10:909685-909686(-) m6A 3'UTR//CDS       24981863
chr10:909744-909745(-) m6A 3'UTR//CDS       -
chr10:909753-909754(-) m6A 3'UTR//CDS       -
chr10:909768-909769(-) m6A 3'UTR//CDS       -
chr10:910076-910077(-) m6A 3'UTR//CDS       22575960
chr10:977583-977584(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
LARP4B
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: LARP4B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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