Basic Information:

  VIRBase ID:  

HHID00008374

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          SWAP70:  NM_001297714     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	SWAP70
miRBase Accession/Entrez ID	MIMAT0004512	23075
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC321//SWAP-70

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SWAP70	chr11:9716720(+) A-I      intronic chr11:9743205(+) A-I      intronic chr11:9743168(+) A-I      intronic chr11:9724203(+) A-I      intronic chr11:9743203(+) A-I      intronic chr11:9743204(+) A-I      intronic chr11:9743212(+) A-I      intronic chr11:9743148(+) A-I      intronic chr11:9721252(+) A-I      intronic chr11:9721250(+) A-I      intronic chr11:9721245(+) A-I      intronic chr11:9721243(+) A-I      intronic chr11:9721173(+) A-I      intronic chr11:9721169(+) A-I      intronic chr11:9721128(+) A-I      intronic chr11:9719092(+) A-I      intronic chr11:9719077(+) A-I      intronic chr11:9719039(+) A-I      intronic chr11:9718969(+) A-I      intronic chr11:9742546(+) A-I      intronic chr11:9718923(+) A-I      intronic chr11:9718503(+) A-I      intronic chr11:9716761(+) A-I      intronic chr11:9696625(+) A-I      intronic chr11:9724126(+) A-I      intronic chr11:9696097(+) A-I      intronic chr11:9716710(+) A-I      intronic chr11:9716626(+) A-I      intronic chr11:9696076(+) A-I      intronic chr11:9716660(+) A-I      intronic chr11:9716616(+) A-I      intronic chr11:9712747(+) A-I      intronic chr11:9766332(+) A-I      intronic chr11:9723061(+) A-I      intronic chr11:9763536(+) A-I      intronic chr11:9712739(+) A-I      intronic chr11:9712704(+) A-I      intronic chr11:9712674(+) A-I      intronic chr11:9712665(+) A-I      intronic chr11:9711972(+) A-I      intronic chr11:9711941(+) A-I      intronic chr11:9711926(+) A-I      intronic chr11:9711857(+) A-I      intronic chr11:9704809(+) A-I      intronic chr11:9732691(+) A-I      intronic chr11:9704783(+) A-I      intronic chr11:9704271(+) A-I      intronic chr11:9696567(+) A-I      intronic chr11:9696498(+) A-I      intronic chr11:9696334(+) A-I      intronic chr11:9696300(+) A-I      intronic chr11:9696146(+) A-I      intronic chr11:9696009(+) A-I      intronic chr11:9696007(+) A-I      intronic chr11:9695991(+) A-I      intronic chr11:9695710(+) A-I      intronic chr11:9695631(+) A-I      intronic chr11:9692562(+) A-I      intronic chr11:9692561(+) A-I      intronic chr11:9692507(+) A-I      intronic chr11:9692499(+) A-I      intronic chr11:9692474(+) A-I      intronic chr11:9692467(+) A-I      intronic chr11:9691528(+) A-I      intronic chr11:9691460(+) A-I      intronic chr11:9691436(+) A-I      intronic chr11:9691039(+) A-I      intronic chr11:9690977(+) A-I      intronic chr11:9749052(+) A-I      intronic chr11:9747033(+) A-I      intronic chr11:9690876(+) A-I      intronic chr11:9690814(+) A-I      intronic chr11:9747302(+) A-I      intronic chr11:9687819(+) A-I      intronic chr11:9687758(+) A-I      intronic chr11:9719104(+) A-I      intronic chr11:9694110(+) A-I      intronic chr11:9704673(+) A-I      intronic chr11:9704786(+) A-I      intronic chr11:9718531(+) A-I      intronic chr11:9747027(+) A-I      intronic chr11:9721201(+) A-I      intronic chr11:9734057(+) A-I      intronic chr11:9765649(+) A-I      intronic chr11:9734026(+) A-I      intronic chr11:9721130(+) A-I      intronic chr11:9766200(+) A-I      intronic chr11:9721289(+) A-I      intronic chr11:9764064(+) A-I      intronic chr11:9764050(+) A-I      intronic chr11:9764049(+) A-I      intronic chr11:9763904(+) A-I      intronic chr11:9759349(+) A-I      intronic chr11:9759345(+) A-I      intronic chr11:9759292(+) A-I      intronic chr11:9759267(+) A-I      intronic chr11:9770923(+) A-I      intronic chr11:9766406(+) A-I      intronic chr11:9766371(+) A-I      intronic chr11:9759262(+) A-I      intronic chr11:9759257(+) A-I      intronic chr11:9691413(+) A-I      intronic chr11:9766335(+) A-I      intronic chr11:9759234(+) A-I      intronic chr11:9766308(+) A-I      intronic chr11:9766299(+) A-I      intronic chr11:9766296(+) A-I      intronic chr11:9766294(+) A-I      intronic chr11:9747393(+) A-I      intronic chr11:9766293(+) A-I      intronic chr11:9747391(+) A-I      intronic chr11:9766290(+) A-I      intronic chr11:9746975(+) A-I      intronic chr11:9766279(+) A-I      intronic chr11:9741016(+) A-I      intronic chr11:9740702(+) A-I      intronic chr11:9722818(+) A-I      intronic chr11:9740697(+) A-I      intronic chr11:9740482(+) A-I      intronic chr11:9734076(+) A-I      intronic chr11:9734059(+) A-I      intronic chr11:9766208(+) A-I      intronic chr11:9740536(+) A-I      intronic chr11:9766205(+) A-I      intronic chr11:9734040(+) A-I      intronic chr11:9765716(+) A-I      intronic chr11:9734018(+) A-I      intronic chr11:9704933(+) A-I      intronic chr11:9726140(+) A-I      intronic chr11:9726021(+) A-I      intronic chr11:9765708(+) A-I      intronic chr11:9726006(+) A-I      intronic chr11:9726005(+) A-I      intronic chr11:9765694(+) A-I      intronic chr11:9724110(+) A-I      intronic chr11:9724059(+) A-I      intronic chr11:9704731(+) A-I      intronic chr11:9765675(+) A-I      intronic chr11:9740516(+) A-I      intronic chr11:9724018(+) A-I      intronic chr11:9722982(+) A-I      intronic chr11:9722953(+) A-I      intronic chr11:9721342(+) A-I      intronic chr11:9721282(+) A-I      intronic chr11:9765651(+) A-I      intronic chr11:9721272(+) A-I      intronic chr11:9716655(+) A-I      intronic chr11:9721256(+) A-I      intronic chr11:9771773(+) A-I      3'UTR chr11:9771732(+) A-I      3'UTR chr11:9771698(+) A-I      3'UTR chr11:9771816(+) A-I      3'UTR chr11:9771767(+) A-I      3'UTR chr11:9771768(+) A-I      3'UTR chr11:9771843(+) A-I      3'UTR chr11:9771890(+) A-I      3'UTR chr11:9740398(+) A-I      intronic chr11:9693962(+) A-I      intronic chr11:9724230(+) A-I      intronic chr11:9712005(+) A-I      intronic chr11:9740586(+) A-I      intronic chr11:9766438(+) A-I      intronic chr11:9747356(+) A-I      intronic chr11:9763984(+) A-I      intronic chr11:9691473(+) A-I      intronic chr11:9694142(+) A-I      intronic chr11:9704973(+) A-I      intronic chr11:9696395(+) A-I      intronic chr11:9712630(+) A-I      intronic chr11:9742463(+) A-I      intronic chr11:9748680(+) A-I      intronic chr11:9718959(+) A-I      intronic chr11:9721147(+) A-I      intronic chr11:9722819(+) A-I      intronic chr11:9721251(+) A-I      intronic chr11:9734063(+) A-I      intronic chr11:9740952(+) A-I      intronic chr11:9740775(+) A-I      intronic chr11:9696082(+) A-I      intronic chr11:9740399(+) A-I      intronic chr11:9704814(+) A-I      intronic chr11:9726123(+) A-I      intronic chr11:9740877(+) A-I      intronic chr11:9719064(+) A-I      intronic chr11:9691514(+) A-I      intronic chr11:9704692(+) A-I      intronic chr11:9763541(+) A-I      intronic chr11:9724061(+) A-I      intronic chr11:9691515(+) A-I      intronic chr11:9717491(+) A-I      intronic chr11:9732509(+) A-I      intronic chr11:9704883(+) A-I      intronic chr11:9719347(+) A-I      intronic chr11:9721253(+) A-I      intronic chr11:9748749(+) A-I      intronic chr11:9722813(+) A-I      intronic chr11:9717443(+) A-I      intronic chr11:9687726(+) A-I      intronic chr11:9691554(+) A-I      intronic chr11:9731256(+) A-I      intronic chr11:9695503(+) A-I      intronic chr11:9724477(+) A-I      intronic chr11:9734013(+) A-I      intronic chr11:9724058(+) A-I      intronic chr11:9704404(+) A-I      intronic chr11:9748814(+) A-I      intronic chr11:9732669(+) A-I      intronic chr11:9740926(+) A-I      intronic chr11:9690879(+) A-I      intronic chr11:9688494(+) A-I      intronic chr11:9734025(+) A-I      intronic chr11:9724516(+) A-I      intronic chr11:9732703(+) A-I      intronic chr11:9696369(+) A-I      intronic chr11:9734031(+) A-I      intronic chr11:9695628(+) A-I      intronic chr11:9740690(+) A-I      intronic chr11:9732697(+) A-I      intronic chr11:9695473(+) A-I      intronic chr11:9691544(+) A-I      intronic chr11:9712604(+) A-I      intronic chr11:9691524(+) A-I      intronic chr11:9734080(+) A-I      intronic chr11:9721220(+) A-I      intronic chr11:9747258(+) A-I      intronic chr11:9763983(+) A-I      intronic chr11:9747348(+) A-I      intronic chr11:9726120(+) A-I      intronic chr11:9704798(+) A-I      intronic chr11:9718506(+) A-I      intronic chr11:9696468(+) A-I      intronic chr11:9759189(+) A-I      intronic chr11:9704888(+) A-I      intronic chr11:9719465(+) A-I      intronic chr11:9734506(+) A-I      intronic chr11:9716721(+) A-I      intronic chr11:9704446(+) A-I      intronic chr11:9712545(+) A-I      intronic chr11:9742543(+) A-I      intronic chr11:9766344(+) A-I      intronic chr11:9740497(+) A-I      intronic chr11:9696612(+) A-I      intronic chr11:9704365(+) A-I      intronic chr11:9696018(+) A-I      intronic chr11:9704324(+) A-I      intronic chr11:9704411(+) A-I      intronic chr11:9712606(+) A-I      intronic chr11:9740825(+) A-I      intronic chr11:9695657(+) A-I      intronic chr11:9718934(+) A-I      intronic chr11:9691580(+) A-I      intronic chr11:9696100(+) A-I      intronic chr11:9712004(+) A-I      intronic chr11:9696106(+) A-I      intronic chr11:9716762(+) A-I      intronic chr11:9721249(+) A-I      intronic chr11:9695559(+) A-I      intronic chr11:9764067(+) A-I      intronic chr11:9716665(+) A-I      intronic chr11:9718577(+) A-I      intronic chr11:9747299(+) A-I      intronic chr11:9691499(+) A-I      intronic chr11:9771777(+) A-I      3'UTR chr11:9771709(+) A-I      3'UTR chr11:9771699(+) A-I      3'UTR chr11:9771741(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SWAP70	chr11:9720731(+) A-I intron -    21960545 chr11:9724058(+) A-I intron -    21960545 chr11:9724059(+) A-I intron -    21960545 chr11:9724477(+) A-G intron -    22484847 chr11:9724516(+) A-G intron -    22484847 chr11:9734080(+) A-G intron -    22484847 chr11:9696100(+) A-G intron -    22484847 chr11:9718531(+) A-G intron -    22484847 chr11:9740536(+) A-G intron -    22484847 chr11:9763536(+) A-G intron -    22484847 chr11:9763983(+) A-G intron -    22484847 chr11:9763984(+) A-G intron -    22484847 chr11:9771698(+) A-G intron -    22484847 chr11:9771732(+) A-G intron -    22484847 chr11:9771767(+) A-G intron -    22484847 chr11:9771768(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SWAP70	chr11:9746260-9746261(+) m6A 3'UTR//CDS//exon       22608085 chr11:9746269-9746270(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr11:9746320-9746321(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr11:9746344-9746345(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746364-9746365(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746372-9746373(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746407-9746408(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9754151-9754152(+) m6A 3'UTR//CDS//exon       24981863 chr11:9754175-9754176(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9754184-9754185(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9754205-9754206(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759761-9759762(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759813-9759814(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759824-9759825(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761732-9761733(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761747-9761748(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761771-9761772(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761777-9761778(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761809-9761810(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761849-9761850(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761871-9761872(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761913-9761914(+) m6A exon//intron       24284625//24209618//24981863 chr11:9762039-9762040(+) m6A exon//intron       25456834//24981863 chr11:9762048-9762049(+) m6A exon//intron       25456834//24981863 chr11:9762093-9762094(+) m6A exon//intron       25456834 chr11:9763436-9763437(+) m6A exon//intron       - chr11:9763474-9763475(+) m6A exon//intron       24209618//24981863 chr11:9769437-9769438(+) m6A CDS//intron       24209618//24981863//22575960 chr11:9769477-9769478(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr11:9769527-9769528(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr11:9769571-9769572(+) Tm CDS//intron       - chr11:9770669-9770670(+) m6A CDS//intron       24284625//24209618//24981863//27773535 chr11:9770685-9770686(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9770725-9770726(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9771419-9771420(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9771444-9771445(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:9771468-9771469(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:9771488-9771489(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771505-9771506(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771582-9771583(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771591-9771592(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771708-9771709(+) m6A 3'UTR//intron       24981863 chr11:9771877-9771878(+) m6A 3'UTR       24284625//24981863 chr11:9771890-9771891(+) m6A 3'UTR       24284625//24981863 chr11:9771895-9771896(+) m6A 3'UTR       24284625//24981863 chr11:9771900-9771901(+) m6A 3'UTR       24284625//24981863 chr11:9771905-9771906(+) m6A 3'UTR       24284625//24981863 chr11:9771910-9771911(+) m6A 3'UTR       24284625//24981863 chr11:9771918-9771919(+) m6A 3'UTR       24284625//24981863 chr11:9772209-9772210(+) m6A 3'UTR       24981863 chr11:9772268-9772269(+) m6A 3'UTR       24981863 chr11:9772999-9773000(+) m6A 3'UTR       26404942 chr11:9773857-9773858(+) m6A 3'UTR       24284625 chr11:9773894-9773895(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SWAP70	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: SWAP70

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).