Detail Information

Basic Information:


  VIRBase ID:  

HHID00008355

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           MRPL3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p MRPL3
miRBase
Accession/Entrez ID		 MIMAT0004512 11222
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - COXPD9//MRL3//RPML3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MRPL3
chr3:131211916(-) A-I      intronic
chr3:131197649(-) A-I      intronic
chr3:131184618(-) A-I      intronic
chr3:131197607(-) A-I      intronic
chr3:131197620(-) A-I      intronic
chr3:131193905(-) A-I      intronic
chr3:131198687(-) A-I      intronic
chr3:131198607(-) A-I      intronic
chr3:131198522(-) A-I      intronic
chr3:131197700(-) A-I      intronic
chr3:131194261(-) A-I      intronic
chr3:131193822(-) A-I      intronic
chr3:131197788(-) A-I      intronic
chr3:131193892(-) A-I      intronic
chr3:131194327(-) A-I      intronic
chr3:131197715(-) A-I      intronic
chr3:131197719(-) A-I      intronic
chr3:131193787(-) A-I      intronic
chr3:131198632(-) A-I      intronic
chr3:131197625(-) A-I      intronic
chr3:131194241(-) A-I      intronic
chr3:131198433(-) A-I      intronic
chr3:131194320(-) A-I      intronic
chr3:131197828(-) A-I      intronic
chr3:131197816(-) A-I      intronic
chr3:131197796(-) A-I      intronic
chr3:131197779(-) A-I      intronic
chr3:131194247(-) A-I      intronic
chr3:131193802(-) A-I      intronic
chr3:131194260(-) A-I      intronic
chr3:131193708(-) A-I      intronic
chr3:131193800(-) A-I      intronic
chr3:131197826(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MRPL3
chr3:131206292(-) A-G intron -    22484847
chr3:131197613(-) A-G intron -    22484847
chr3:131197615(-) A-G intron -    22484847
chr3:131197621(-) A-G intron -    22484847
chr3:131197732(-) A-G intron -    22484847
chr3:131197796(-) A-G intron -    22484847
chr3:131197816(-) A-G intron -    22484847
chr3:131197826(-) A-G intron -    22484847
chr3:131198431(-) A-G intron -    22484847
chr3:131198500(-) A-G intron -    22484847
chr3:131198632(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MRPL3
chr3:131181546-131181547(-) m6A 3'UTR//exon       27773535
chr3:131190035-131190036(-) m6A CDS//exon       27773535//22575960
chr3:131190046-131190047(-) m6A CDS//exon       27773535//22575960
chr3:131220699-131220700(-) m6A 5'UTR//CDS//intron       27773536
chr3:131221576-131221577(-) m6A CDS//exon//intron       24981863//27371828//27773536//22575960
chr3:131221728-131221729(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//26404942//27371828//27773536//22575960
chr3:131221770-131221771(-) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//27371828//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
MRPL3
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: MRPL3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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