Detail Information

Basic Information:


  VIRBase ID:  

HHID00008322

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           ECI2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p ECI2
miRBase
Accession/Entrez ID		 MIMAT0004512 10455
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACBD2//dJ1013A10.3//DRS-1//DRS1//HCA88//PECI

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ECI2
chr6:4123989(-) A-I      intronic
chr6:4118444(-) A-I      intronic
chr6:4119692(-) A-I      intronic
chr6:4123606(-) A-I      intronic
chr6:4119719(-) A-I      intronic
chr6:4119734(-) A-I      intronic
chr6:4119748(-) A-I      intronic
chr6:4119756(-) A-I      intronic
chr6:4119772(-) A-I      intronic
chr6:4119792(-) A-I      intronic
chr6:4119801(-) A-I      intronic
chr6:4123630(-) A-I      intronic
chr6:4123979(-) A-I      intronic
chr6:4123983(-) A-I      intronic
chr6:4123984(-) A-I      intronic
chr6:4122650(-) A-I      intronic
chr6:4123997(-) A-I      intronic
chr6:4124021(-) A-I      intronic
chr6:4124033(-) A-I      intronic
chr6:4120704(-) A-I      intronic
chr6:4120716(-) A-I      intronic
chr6:4120731(-) A-I      intronic
chr6:4120744(-) A-I      intronic
chr6:4120769(-) A-I      intronic
chr6:4120813(-) A-I      intronic
chr6:4120861(-) A-I      intronic
chr6:4120874(-) A-I      intronic
chr6:4116419(-) A-I      intronic
chr6:4116405(-) A-I      intronic
chr6:4124079(-) A-I      intronic
chr6:4124112(-) A-I      intronic
chr6:4131848(-) A-I      intronic
chr6:4120717(-) A-I      intronic
chr6:4122485(-) A-I      intronic
chr6:4120698(-) A-I      intronic
chr6:4119779(-) A-I      intronic
chr6:4119767(-) A-I      intronic
chr6:4119750(-) A-I      intronic
chr6:4124059(-) A-I      intronic
chr6:4119730(-) A-I      intronic
chr6:4122527(-) A-I      intronic
chr6:4122566(-) A-I      intronic
chr6:4122668(-) A-I      intronic
chr6:4122678(-) A-I      intronic
chr6:4116929(-) A-I      intronic
chr6:4116920(-) A-I      intronic
chr6:4116905(-) A-I      intronic
chr6:4116897(-) A-I      intronic
chr6:4116896(-) A-I      intronic
chr6:4116891(-) A-I      intronic
chr6:4116787(-) A-I      intronic
chr6:4116780(-) A-I      intronic
chr6:4116771(-) A-I      intronic
chr6:4116760(-) A-I      intronic
chr6:4116751(-) A-I      intronic
chr6:4116750(-) A-I      intronic
chr6:4116743(-) A-I      intronic
chr6:4116742(-) A-I      intronic
chr6:4116735(-) A-I      intronic
chr6:4116727(-) A-I      intronic
chr6:4116928(-) A-I      intronic
chr6:4122898(-) A-I      intronic
chr6:4122900(-) A-I      intronic
chr6:4123496(-) A-I      intronic
chr6:4123503(-) A-I      intronic
chr6:4123002(-) A-I      intronic
chr6:4120925(-) A-I      intronic
chr6:4116457(-) A-I      intronic
chr6:4124038(-) A-I      intronic
chr6:4122901(-) A-I      intronic
chr6:4122903(-) A-I      intronic
chr6:4122923(-) A-I      intronic
chr6:4122925(-) A-I      intronic
chr6:4122948(-) A-I      intronic
chr6:4118430(-) A-I      intronic
chr6:4118402(-) A-I      intronic
chr6:4118389(-) A-I      intronic
chr6:4116463(-) A-I      intronic
chr6:4116441(-) A-I      intronic
chr6:4116428(-) A-I      intronic
chr6:4119783(-) A-I      intronic
chr6:4122981(-) A-I      intronic
chr6:4124168(-) A-I      intronic
chr6:4122975(-) A-I      intronic
chr6:4122649(-) A-I      intronic
chr6:4133270(-) A-I      intronic
chr6:4124133(-) A-I      intronic
chr6:4124161(-) A-I      intronic
chr6:4120875(-) A-I      intronic
chr6:4122949(-) A-I      intronic
chr6:4120878(-) A-I      intronic
chr6:4119646(-) A-I      intronic
chr6:4122624(-) A-I      intronic
chr6:4122659(-) A-I      intronic
chr6:4124029(-) A-I      intronic
chr6:4119787(-) A-I      intronic
chr6:4122967(-) A-I      intronic
chr6:4124054(-) A-I      intronic
chr6:4133271(-) A-I      intronic
chr6:4124151(-) A-I      intronic
chr6:4122894(-) A-I      intronic
chr6:4124126(-) A-I      intronic
chr6:4122628(-) A-I      intronic
chr6:4124055(-) A-I      intronic
chr6:4119647(-) A-I      intronic
chr6:4120904(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ECI2
chr6:4116037-4116038(-) m6A 3'UTR//exon       24981863//22608085
chr6:4116113-4116114(-) m6A 3'UTR//CDS//exon       24284625//22608085
chr6:4116135-4116136(-) m6A 3'UTR//CDS//exon       22608085
chr6:4130612-4130613(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr6:4130685-4130686(-) m6A 3'UTR//CDS//exon       27773535
chr6:4130712-4130713(-) m6A 3'UTR//CDS//exon       27773535
chr6:4130777-4130778(-) m6A CDS//exon       27773535
chr6:4131069-4131070(-) m6A CDS//exon       27773535
chr6:4131087-4131088(-) m6A CDS//exon       27773535
chr6:4133803-4133804(-) m6A CDS//exon       27773535
chr6:4133842-4133843(-) m6A CDS//exon       24981863//27773535
chr6:4133870-4133871(-) m6A CDS//exon       24981863//27773535
chr6:4133895-4133896(-) m6A CDS//exon       24981863//27773535
chr6:4133974-4133975(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr6:4134013-4134014(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr6:4135767-4135768(-) m6A 5'UTR//CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ECI2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: ECI2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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