Detail Information

Basic Information:


  VIRBase ID:  

HHID00008310

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           TOB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p TOB1
miRBase
Accession/Entrez ID		 MIMAT0004512 10140
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - APRO5//APRO6//PIG49//TOB//TROB//TROB1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TOB1
chr17:48940093-48940094(-) m6A 3'UTR       26404942
chr17:48940205-48940206(-) m6A 3'UTR       26404942
chr17:48940588-48940589(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr17:48940989-48940990(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941003-48941004(-) Y CDS//exon       26075521
chr17:48941057-48941058(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941145-48941146(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941171-48941172(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941184-48941185(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941276-48941277(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941285-48941286(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48941401-48941402(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr17:48941443-48941444(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr17:48941448-48941449(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr17:48941521-48941522(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22608085
chr17:48944886-48944887(-) m6A 5'UTR       24284625//25456834//24981863//27371828
chr17:48945179-48945180(-) m6A 5'UTR       24284625//25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TOB1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: TOB1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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