Basic Information:

  VIRBase ID:  

HHID00008305

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          RBX1:  NM_014248     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	RBX1
miRBase Accession/Entrez ID	MIMAT0004512	9978
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BA554C12.1//RNF75//ROC1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RBX1	chr22:41366210(+) A-I      intronic chr22:41366209(+) A-I      intronic chr22:41366204(+) A-I      intronic chr22:41366195(+) A-I      intronic chr22:41358210(+) A-I      intronic chr22:41366183(+) A-I      intronic chr22:41365229(+) A-I      intronic chr22:41365228(+) A-I      intronic chr22:41365213(+) A-I      intronic chr22:41364221(+) A-I      intronic chr22:41364212(+) A-I      intronic chr22:41349090(+) A-I      intronic chr22:41349120(+) A-I      intronic chr22:41353199(+) A-I      intronic chr22:41359482(+) A-I      intronic chr22:41354992(+) A-I      intronic chr22:41355995(+) A-I      intronic chr22:41358170(+) A-I      intronic chr22:41353464(+) A-I      intronic chr22:41364150(+) A-I      intronic chr22:41365202(+) A-I      intronic chr22:41349088(+) A-I      intronic chr22:41353474(+) A-I      intronic chr22:41349180(+) A-I      intronic chr22:41349094(+) A-I      intronic chr22:41349074(+) A-I      intronic chr22:41354087(+) A-I      intronic chr22:41354868(+) A-I      intronic chr22:41354898(+) A-I      intronic chr22:41354963(+) A-I      intronic chr22:41354967(+) A-I      intronic chr22:41354970(+) A-I      intronic chr22:41354979(+) A-I      intronic chr22:41355655(+) A-I      intronic chr22:41355663(+) A-I      intronic chr22:41355666(+) A-I      intronic chr22:41355672(+) A-I      intronic chr22:41355726(+) A-I      intronic chr22:41355730(+) A-I      intronic chr22:41355735(+) A-I      intronic chr22:41355764(+) A-I      intronic chr22:41355804(+) A-I      intronic chr22:41355896(+) A-I      intronic chr22:41355944(+) A-I      intronic chr22:41356781(+) A-I      intronic chr22:41356842(+) A-I      intronic chr22:41356915(+) A-I      intronic chr22:41356977(+) A-I      intronic chr22:41356989(+) A-I      intronic chr22:41357002(+) A-I      intronic chr22:41357048(+) A-I      intronic chr22:41357237(+) A-I      intronic chr22:41357651(+) A-I      intronic chr22:41357670(+) A-I      intronic chr22:41353986(+) A-I      intronic chr22:41353970(+) A-I      intronic chr22:41356099(+) A-I      intronic chr22:41367795(+) A-I      intronic chr22:41367783(+) A-I      intronic chr22:41367782(+) A-I      intronic chr22:41367741(+) A-I      intronic chr22:41366315(+) A-I      intronic chr22:41366217(+) A-I      intronic chr22:41365869(+) A-I      intronic chr22:41365821(+) A-I      intronic chr22:41365736(+) A-I      intronic chr22:41365156(+) A-I      intronic chr22:41365063(+) A-I      intronic chr22:41364181(+) A-I      intronic chr22:41361586(+) A-I      intronic chr22:41361150(+) A-I      intronic chr22:41361045(+) A-I      intronic chr22:41359783(+) A-I      intronic chr22:41359688(+) A-I      intronic chr22:41359644(+) A-I      intronic chr22:41359430(+) A-I      intronic chr22:41359407(+) A-I      intronic chr22:41359106(+) A-I      intronic chr22:41358639(+) A-I      intronic chr22:41358519(+) A-I      intronic chr22:41358231(+) A-I      intronic chr22:41358218(+) A-I      intronic chr22:41358125(+) A-I      intronic chr22:41357998(+) A-I      intronic chr22:41357888(+) A-I      intronic chr22:41357868(+) A-I      intronic chr22:41357863(+) A-I      intronic chr22:41353932(+) A-I      intronic chr22:41353804(+) A-I      intronic chr22:41353794(+) A-I      intronic chr22:41353786(+) A-I      intronic chr22:41353768(+) A-I      intronic chr22:41353735(+) A-I      intronic chr22:41353733(+) A-I      intronic chr22:41353581(+) A-I      intronic chr22:41353448(+) A-I      intronic chr22:41353372(+) A-I      intronic chr22:41353290(+) A-I      intronic chr22:41353222(+) A-I      intronic chr22:41353218(+) A-I      intronic chr22:41353190(+) A-I      intronic chr22:41353179(+) A-I      intronic chr22:41352928(+) A-I      intronic chr22:41352892(+) A-I      intronic chr22:41352885(+) A-I      intronic chr22:41352878(+) A-I      intronic chr22:41352860(+) A-I      intronic chr22:41352829(+) A-I      intronic chr22:41352823(+) A-I      intronic chr22:41352822(+) A-I      intronic chr22:41352669(+) A-I      intronic chr22:41352575(+) A-I      intronic chr22:41352535(+) A-I      intronic chr22:41352495(+) A-I      intronic chr22:41350948(+) A-I      intronic chr22:41350946(+) A-I      intronic chr22:41350943(+) A-I      intronic chr22:41350885(+) A-I      intronic chr22:41350230(+) A-I      intronic chr22:41350169(+) A-I      intronic chr22:41350152(+) A-I      intronic chr22:41350123(+) A-I      intronic chr22:41350122(+) A-I      intronic chr22:41350097(+) A-I      intronic chr22:41350037(+) A-I      intronic chr22:41350029(+) A-I      intronic chr22:41350004(+) A-I      intronic chr22:41349195(+) A-I      intronic chr22:41349184(+) A-I      intronic chr22:41361574(+) A-I      intronic chr22:41354998(+) A-I      intronic chr22:41366280(+) A-I      intronic chr22:41361479(+) A-I      intronic chr22:41355694(+) A-I      intronic chr22:41359484(+) A-I      intronic chr22:41354030(+) A-I      intronic chr22:41357928(+) A-I      intronic chr22:41353781(+) A-I      intronic chr22:41355027(+) A-I      intronic chr22:41355644(+) A-I      intronic chr22:41352785(+) A-I      intronic chr22:41356002(+) A-I      intronic chr22:41350021(+) A-I      intronic chr22:41359478(+) A-I      intronic chr22:41354238(+) A-I      intronic chr22:41359662(+) A-I      intronic chr22:41359805(+) A-I      intronic chr22:41355972(+) A-I      intronic chr22:41358206(+) A-I      intronic chr22:41355557(+) A-I      intronic chr22:41355866(+) A-I      intronic chr22:41364260(+) A-I      intronic chr22:41351065(+) A-I      intronic chr22:41355988(+) A-I      intronic chr22:41361508(+) A-I      intronic chr22:41357615(+) A-I      intronic chr22:41353929(+) A-I      intronic chr22:41350026(+) A-I      intronic chr22:41349016(+) A-I      intronic chr22:41356889(+) A-I      intronic chr22:41353174(+) A-I      intronic chr22:41358049(+) A-I      intronic chr22:41350162(+) A-I      intronic chr22:41359549(+) A-I      intronic chr22:41359765(+) A-I      intronic chr22:41367664(+) A-I      intronic chr22:41358523(+) A-I      intronic chr22:41359480(+) A-I      intronic chr22:41364195(+) A-I      intronic chr22:41349122(+) A-I      intronic chr22:41355613(+) A-I      intronic chr22:41353930(+) A-I      intronic chr22:41357820(+) A-I      intronic chr22:41349075(+) A-I      intronic chr22:41364207(+) A-I      intronic chr22:41353495(+) A-I      intronic chr22:41365231(+) A-I      intronic chr22:41353933(+) A-I      intronic chr22:41349998(+) A-I      intronic chr22:41361290(+) A-I      intronic chr22:41353394(+) A-I      intronic chr22:41359046(+) A-I      intronic chr22:41354070(+) A-I      intronic chr22:41365206(+) A-I      intronic chr22:41353552(+) A-I      intronic chr22:41358669(+) A-I      intronic chr22:41350153(+) A-I      intronic chr22:41349095(+) A-I      intronic chr22:41361054(+) A-I      intronic chr22:41359105(+) A-I      intronic chr22:41350111(+) A-I      intronic chr22:41352529(+) A-I      intronic chr22:41352889(+) A-I      intronic chr22:41358236(+) A-I      intronic chr22:41359036(+) A-I      intronic chr22:41354917(+) A-I      intronic chr22:41361628(+) A-I      intronic chr22:41355749(+) A-I      intronic chr22:41353096(+) A-I      intronic chr22:41351068(+) A-I      intronic chr22:41354952(+) A-I      intronic chr22:41355581(+) A-I      intronic chr22:41365745(+) A-I      intronic chr22:41365611(+) A-I      intronic chr22:41365197(+) A-I      intronic chr22:41353531(+) A-I      intronic chr22:41358157(+) A-I      intronic chr22:41357030(+) A-I      intronic chr22:41355082(+) A-I      intronic chr22:41352861(+) A-I      intronic chr22:41352471(+) A-I      intronic chr22:41358023(+) A-I      intronic chr22:41352631(+) A-I      intronic chr22:41354016(+) A-I      intronic chr22:41354100(+) A-I      intronic chr22:41349999(+) A-I      intronic chr22:41358599(+) A-I      intronic chr22:41365134(+) A-I      intronic chr22:41355959(+) A-I      intronic chr22:41352855(+) A-I      intronic chr22:41359030(+) A-I      intronic chr22:41349178(+) A-I      intronic chr22:41359770(+) A-I      intronic chr22:41367579(+) A-I      intronic chr22:41354147(+) A-I      intronic chr22:41359529(+) A-I      intronic chr22:41349179(+) A-I      intronic chr22:41350126(+) A-I      intronic chr22:41359694(+) A-I      intronic chr22:41355975(+) A-I      intronic chr22:41359384(+) A-I      intronic chr22:41353974(+) A-I      intronic chr22:41358078(+) A-I      intronic chr22:41356033(+) A-I      intronic chr22:41359118(+) A-I      intronic chr22:41353395(+) A-I      intronic chr22:41359456(+) A-I      intronic chr22:41354841(+) A-I      intronic chr22:41359619(+) A-I      intronic chr22:41361545(+) A-I      intronic chr22:41354947(+) A-I      intronic chr22:41353617(+) A-I      intronic chr22:41358350(+) A-I      intronic chr22:41350974(+) A-I      intronic chr22:41352552(+) A-I      intronic chr22:41353337(+) A-I      intronic chr22:41353215(+) A-I      intronic chr22:41355969(+) A-I      intronic chr22:41353678(+) A-I      intronic chr22:41353968(+) A-I      intronic chr22:41358053(+) A-I      intronic chr22:41353637(+) A-I      intronic chr22:41354983(+) A-I      intronic chr22:41356034(+) A-I      intronic chr22:41356948(+) A-I      intronic chr22:41356856(+) A-I      intronic chr22:41358186(+) A-I      intronic chr22:41352862(+) A-I      intronic chr22:41357279(+) A-I      intronic chr22:41359464(+) A-I      intronic chr22:41352687(+) A-I      intronic chr22:41355001(+) A-I      intronic chr22:41364188(+) A-I      intronic chr22:41358280(+) A-I      intronic chr22:41366184(+) A-I      intronic chr22:41358289(+) A-I      intronic chr22:41366118(+) A-I      intronic chr22:41365732(+) A-I      intronic chr22:41353741(+) A-I      intronic chr22:41367808(+) A-I      intronic chr22:41361310(+) A-I      intronic chr22:41353281(+) A-I      intronic chr22:41355605(+) A-I      intronic chr22:41352880(+) A-I      intronic chr22:41352762(+) A-I      intronic chr22:41359519(+) A-I      intronic chr22:41350078(+) A-I      intronic chr22:41352918(+) A-I      intronic chr22:41352882(+) A-I      intronic chr22:41357557(+) A-I      intronic chr22:41358961(+) A-I      intronic chr22:41353113(+) A-I      intronic chr22:41350042(+) A-I      intronic chr22:41352933(+) A-I      intronic chr22:41357221(+) A-I      intronic chr22:41353228(+) A-I      intronic chr22:41353689(+) A-I      intronic chr22:41352879(+) A-I      intronic chr22:41353958(+) A-I      intronic chr22:41359560(+) A-I      intronic chr22:41352555(+) A-I      intronic chr22:41359722(+) A-I      intronic chr22:41354088(+) A-I      intronic chr22:41352778(+) A-I      intronic chr22:41365160(+) A-I      intronic chr22:41353163(+) A-I      intronic chr22:41358600(+) A-I      intronic chr22:41357954(+) A-I      intronic chr22:41355668(+) A-I      intronic chr22:41355849(+) A-I      intronic chr22:41365679(+) A-I      intronic chr22:41357029(+) A-I      intronic chr22:41365170(+) A-I      intronic chr22:41356957(+) A-I      intronic chr22:41361070(+) A-I      intronic chr22:41357889(+) A-I      intronic chr22:41356832(+) A-I      intronic chr22:41359520(+) A-I      intronic chr22:41359454(+) A-I      intronic chr22:41356959(+) A-I      intronic chr22:41352480(+) A-I      intronic chr22:41350108(+) A-I      intronic chr22:41353592(+) A-I      intronic chr22:41354199(+) A-I      intronic chr22:41358232(+) A-I      intronic chr22:41352839(+) A-I      intronic chr22:41350890(+) A-I      intronic chr22:41353189(+) A-I      intronic chr22:41361059(+) A-I      intronic chr22:41350175(+) A-I      intronic chr22:41355639(+) A-I      intronic chr22:41358983(+) A-I      intronic chr22:41353473(+) A-I      intronic chr22:41358205(+) A-I      intronic chr22:41358050(+) A-I      intronic chr22:41356867(+) A-I      intronic chr22:41356070(+) A-I      intronic chr22:41361562(+) A-I      intronic chr22:41364120(+) A-I      intronic chr22:41353198(+) A-I      intronic chr22:41365117(+) A-I      intronic chr22:41353772(+) A-I      intronic chr22:41359732(+) A-I      intronic chr22:41358255(+) A-I      intronic chr22:41359385(+) A-I      intronic chr22:41358962(+) A-I      intronic chr22:41353587(+) A-I      intronic chr22:41358362(+) A-I      intronic chr22:41365085(+) A-I      intronic chr22:41354911(+) A-I      intronic chr22:41356036(+) A-I      intronic chr22:41357989(+) A-I      intronic chr22:41366236(+) A-I      intronic chr22:41354922(+) A-I      intronic chr22:41359779(+) A-I      intronic chr22:41353715(+) A-I      intronic chr22:41367813(+) A-I      intronic chr22:41356951(+) A-I      intronic chr22:41355765(+) A-I      intronic chr22:41359707(+) A-I      intronic chr22:41353354(+) A-I      intronic chr22:41350194(+) A-I      intronic chr22:41350193(+) A-I      intronic chr22:41353168(+) A-I      intronic chr22:41356001(+) A-I      intronic chr22:41365512(+) A-I      intronic chr22:41350201(+) A-I      intronic chr22:41358580(+) A-I      intronic chr22:41359769(+) A-I      intronic chr22:41364357(+) A-I      intronic chr22:41349160(+) A-I      intronic chr22:41359027(+) A-I      intronic chr22:41357218(+) A-I      intronic chr22:41349262(+) A-I      intronic chr22:41359492(+) A-I      intronic chr22:41355094(+) A-I      intronic chr22:41361525(+) A-I      intronic chr22:41353164(+) A-I      intronic chr22:41365268(+) A-I      intronic chr22:41359669(+) A-I      intronic chr22:41365223(+) A-I      intronic chr22:41353915(+) A-I      intronic chr22:41350043(+) A-I      intronic chr22:41359636(+) A-I      intronic chr22:41364329(+) A-I      intronic chr22:41352784(+) A-I      intronic chr22:41366233(+) A-I      intronic chr22:41359746(+) A-I      intronic chr22:41355799(+) A-I      intronic chr22:41355650(+) A-I      intronic chr22:41353797(+) A-I      intronic chr22:41359475(+) A-I      intronic chr22:41353591(+) A-I      intronic chr22:41367800(+) A-I      intronic chr22:41365825(+) A-I      intronic chr22:41359425(+) A-I      intronic chr22:41354027(+) A-I      intronic chr22:41361645(+) A-I      intronic chr22:41365196(+) A-I      intronic chr22:41365153(+) A-I      intronic chr22:41349124(+) A-I      intronic chr22:41350908(+) A-I      intronic chr22:41358974(+) A-I      intronic chr22:41353339(+) A-I      intronic chr22:41359536(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RBX1	chr22:41356892(+) A-I intron -    21960545 chr22:41358235(+) A-I intron -    21960545 chr22:41358236(+) A-I intron -    21960545 chr22:41349262(+) A-G intron -    22484847 chr22:41350108(+) A-G intron -    22484847 chr22:41350974(+) A-G intron -    22484847 chr22:41351338(+) A-G intron -    22484847 chr22:41352544(+) A-G intron -    22484847 chr22:41352785(+) A-G intron -    22484847 chr22:41352790(+) A-G intron -    22484847 chr22:41353096(+) A-G intron -    22484847 chr22:41355551(+) A-G intron -    22484847 chr22:41355557(+) A-G intron -    22484847 chr22:41355581(+) A-G intron -    22484847 chr22:41355988(+) A-G intron -    22484847 chr22:41356002(+) A-G intron -    22484847 chr22:41356036(+) A-G intron -    22484847 chr22:41357969(+) A-G intron -    22484847 chr22:41357972(+) A-G intron -    22484847 chr22:41358157(+) A-G intron -    22484847 chr22:41358232(+) A-G intron -    22484847 chr22:41358235(+) A-G intron -    22484847 chr22:41359464(+) A-G intron -    22484847 chr22:41359732(+) A-G intron -    22484847 chr22:41359746(+) A-G intron -    22484847 chr22:41359769(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RBX1	chr22:41347386-41347387(+) m6A 5'UTR//exon       24981863 chr22:41363863-41363864(+) m6A CDS//exon       27773535 chr22:41368498-41368499(+) m6A 3'UTR//exon       27773535 chr22:41368577-41368578(+) m6A 3'UTR//exon       27773535 chr22:41368940-41368941(+) m6A 3'UTR       24284625//25456834 chr22:41369013-41369014(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr22:41369045-41369046(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr22:41369093-41369094(+) m6A 3'UTR       24284625//25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	RBX1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: RBX1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).