Basic Information:

  VIRBase ID:  

HHID00008284

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          SOCS5:  NM_144949     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	SOCS5
miRBase Accession/Entrez ID	MIMAT0004512	9655
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CIS6//Cish5//CISH6//SOCS-5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	SOCS5	chr2: 47005147     chr2: 47005111     chr2: 47005091     chr2: 47005101     chr2: 47005102     chr2: 47004960     chr2: 47005068

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SOCS5	chr2:46957624(+) A-I      intronic chr2:46957578(+) A-I      intronic chr2:46957619(+) A-I      intronic chr2:46957580(+) A-I      intronic chr2:46960629(+) A-I      intronic chr2:46960627(+) A-I      intronic chr2:46957628(+) A-I      intronic chr2:46957575(+) A-I      intronic chr2:46942431(+) A-I      intronic chr2:46969844(+) A-I      intronic chr2:46969830(+) A-I      intronic chr2:46940352(+) A-I      intronic chr2:46939612(+) A-I      intronic chr2:46973696(+) A-I      intronic chr2:46973716(+) A-I      intronic chr2:46940415(+) A-I      intronic chr2:46960591(+) A-I      intronic chr2:46957596(+) A-I      intronic chr2:46960721(+) A-I      intronic chr2:46957466(+) A-I      intronic chr2:46957462(+) A-I      intronic chr2:46955812(+) A-I      intronic chr2:46942532(+) A-I      intronic chr2:46943827(+) A-I      intronic chr2:46943818(+) A-I      intronic chr2:46943746(+) A-I      intronic chr2:46973643(+) A-I      intronic chr2:46973669(+) A-I      intronic chr2:46955796(+) A-I      intronic chr2:46955794(+) A-I      intronic chr2:46969905(+) A-I      intronic chr2:46960637(+) A-I      intronic chr2:46969898(+) A-I      intronic chr2:46955722(+) A-I      intronic chr2:46984885(+) A-I      intronic chr2:46968517(+) A-I      intronic chr2:46975578(+) A-I      intronic chr2:46968459(+) A-I      intronic chr2:46984859(+) A-I      intronic chr2:46943832(+) A-I      intronic chr2:46939583(+) A-I      intronic chr2:46940313(+) A-I      intronic chr2:46943850(+) A-I      intronic chr2:46957688(+) A-I      intronic chr2:46940311(+) A-I      intronic chr2:46971326(+) A-I      intronic chr2:46940258(+) A-I      intronic chr2:46942399(+) A-I      intronic chr2:46955943(+) A-I      intronic chr2:46960615(+) A-I      intronic chr2:46943734(+) A-I      intronic chr2:46943807(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SOCS5	chr2:46939583(+) A-G intron -    22484847 chr2:46940311(+) A-G intron -    22484847 chr2:46940313(+) A-G intron -    22484847 chr2:46971289(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SOCS5	chr2:46926362-46926363(+) m1A 5'UTR//intron       26863196//26863410 chr2:46926501-46926502(+) m6A 5'UTR//intron       24209618 chr2:46985760-46985761(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:46985766-46985767(+) m6A CDS       24284625//24209618//24981863//22608085 chr2:46985799-46985800(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:46985814-46985815(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:46985984-46985985(+) m6A CDS       24284625//25456834//24981863//22608085 chr2:46985989-46985990(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986043-46986044(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986062-46986063(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986101-46986102(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986112-46986113(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986162-46986163(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986179-46986180(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986202-46986203(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986245-46986246(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986370-46986371(+) m6A CDS       24284625//24981863//22608085 chr2:46986562-46986563(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:46986568-46986569(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:46986606-46986607(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:46986705-46986706(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986727-46986728(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986828-46986829(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986862-46986863(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986888-46986889(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46986903-46986904(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr2:46987030-46987031(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:46987039-46987040(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:46987075-46987076(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr2:46987103-46987104(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr2:46987228-46987229(+) m6A CDS       24284625//24981863//22608085 chr2:46987261-46987262(+) m6A CDS       24981863 chr2:46989432-46989433(+) m6A 3'UTR       24981863 chr2:46989476-46989477(+) m6A 3'UTR       24981863 chr2:46989513-46989514(+) m6A 3'UTR       24981863 chr2:46989520-46989521(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SOCS5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: SOCS5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).