Basic Information:

  VIRBase ID:  

HHID00008242

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          STX11:  NM_003764     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	STX11
miRBase Accession/Entrez ID	MIMAT0004512	8676
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FHL4//HLH4//HPLH4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STX11	chr6:144498780(+) A-I      intronic chr6:144498766(+) A-I      intronic chr6:144495776(+) A-I      intronic chr6:144495740(+) A-I      intronic chr6:144495739(+) A-I      intronic chr6:144495737(+) A-I      intronic chr6:144498723(+) A-I      intronic chr6:144498736(+) A-I      intronic chr6:144498767(+) A-I      intronic chr6:144496092(+) A-I      intronic chr6:144485894(+) A-I      intronic chr6:144485951(+) A-I      intronic chr6:144485970(+) A-I      intronic chr6:144495998(+) A-I      intronic chr6:144496062(+) A-I      intronic chr6:144498740(+) A-I      intronic chr6:144496119(+) A-I      intronic chr6:144496591(+) A-I      intronic chr6:144498674(+) A-I      intronic chr6:144498689(+) A-I      intronic chr6:144498697(+) A-I      intronic chr6:144498722(+) A-I      intronic chr6:144473910(+) A-I      intronic chr6:144473928(+) A-I      intronic chr6:144477393(+) A-I      intronic chr6:144484455(+) A-I      intronic chr6:144484481(+) A-I      intronic chr6:144485027(+) A-I      intronic chr6:144485028(+) A-I      intronic chr6:144485052(+) A-I      intronic chr6:144485829(+) A-I      intronic chr6:144485886(+) A-I      intronic chr6:144495714(+) A-I      intronic chr6:144510349(+) A-I      3'UTR chr6:144510343(+) A-I      3'UTR chr6:144510325(+) A-I      3'UTR chr6:144510326(+) A-I      3'UTR chr6:144495587(+) A-I      intronic chr6:144490956(+) A-I      intronic chr6:144485032(+) A-I      intronic chr6:144502585(+) A-I      intronic chr6:144495782(+) A-I      intronic chr6:144486575(+) A-I      intronic chr6:144509943(+) A-I      3'UTR chr6:144502621(+) A-I      intronic chr6:144496641(+) A-I      intronic chr6:144490962(+) A-I      intronic chr6:144485892(+) A-I      intronic chr6:144495672(+) A-I      intronic chr6:144485834(+) A-I      intronic chr6:144484646(+) A-I      intronic chr6:144476440(+) A-I      intronic chr6:144496618(+) A-I      intronic chr6:144495710(+) A-I      intronic chr6:144496329(+) A-I      intronic chr6:144484715(+) A-I      intronic chr6:144495576(+) A-I      intronic chr6:144496051(+) A-I      intronic chr6:144496280(+) A-I      intronic chr6:144485956(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STX11	chr6:144484439(+) A-G intron -    22484847 chr6:144484646(+) A-G intron -    22484847 chr6:144484714(+) A-G intron -    22484847 chr6:144484715(+) A-G intron -    22484847 chr6:144484811(+) A-G intron -    22484847 chr6:144485867(+) A-G intron -    22484847 chr6:144485892(+) A-G intron -    22484847 chr6:144485956(+) A-G intron -    22484847 chr6:144486512(+) A-G intron -    22484847 chr6:144495576(+) A-G intron -    22484847 chr6:144495710(+) A-G intron -    22484847 chr6:144495782(+) A-G intron -    22484847 chr6:144496008(+) A-G intron -    22484847 chr6:144496166(+) A-G intron -    22484847 chr6:144496177(+) A-G intron -    22484847 chr6:144496280(+) A-G intron -    22484847 chr6:144496299(+) A-G intron -    22484847 chr6:144496329(+) A-G intron -    22484847 chr6:144496332(+) A-G intron -    22484847 chr6:144496583(+) A-G intron -    22484847 chr6:144496618(+) A-G intron -    22484847 chr6:144496641(+) A-G intron -    22484847 chr6:144496644(+) A-G intron -    22484847 chr6:144498702(+) A-G intron -    22484847 chr6:144509943(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STX11	chr6:144471696-144471697(+) m6A 5'UTR       - chr6:144507771-144507772(+) m6A CDS       - chr6:144507784-144507785(+) m6A CDS       - chr6:144507792-144507793(+) m6A CDS       - chr6:144507858-144507859(+) m6A CDS       24981863 chr6:144507876-144507877(+) m6A CDS       24981863 chr6:144507903-144507904(+) m6A CDS       24981863 chr6:144507912-144507913(+) m6A CDS       24981863 chr6:144507927-144507928(+) m6A CDS       24981863 chr6:144508299-144508300(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:144508338-144508339(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:144508402-144508403(+) m6A CDS       24284625//24981863//22608085 chr6:144508581-144508582(+) m6A CDS       24284625 chr6:144508592-144508593(+) m6A CDS       24284625 chr6:144508661-144508662(+) m6A 3'UTR       24284625//24981863 chr6:144508738-144508739(+) m6A 3'UTR       24284625//24209618//24981863 chr6:144508780-144508781(+) m6A 3'UTR       24284625//24209618//24981863 chr6:144508916-144508917(+) m6A 3'UTR       24284625//24981863//22608085 chr6:144508971-144508972(+) m6A 3'UTR       24284625//24981863//22608085 chr6:144509012-144509013(+) m6A 3'UTR       24284625//24981863//22608085 chr6:144509025-144509026(+) m6A 3'UTR       24284625//24981863//22608085 chr6:144509099-144509100(+) m6A 3'UTR       24284625//24981863 chr6:144509206-144509207(+) m6A 3'UTR       - chr6:144509281-144509282(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	STX11	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: STX11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).