Basic Information:

  VIRBase ID:  

HHID00008172

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          SLC1A2:  NM_001252652     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	SLC1A2
miRBase Accession/Entrez ID	MIMAT0004512	6506
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DEE41//EAAT2//EIEE41//GLT-1//HBGT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC1A2	chr11:35355317(-) A-I      intronic chr11:35316630(-) A-I      intronic chr11:35408516(-) A-I      intronic chr11:35300019(-) A-I      intronic chr11:35301832(-) A-I      intronic chr11:35407525(-) A-I      intronic chr11:35300075(-) A-I      intronic chr11:35285015(-) A-I      intronic chr11:35373399(-) A-I      intronic chr11:35410206(-) A-I      intronic chr11:35411289(-) A-I      intronic chr11:35284928(-) A-I      intronic chr11:35290035(-) A-I      intronic chr11:35433157(-) A-I      intronic chr11:35383492(-) A-I      intronic chr11:35284939(-) A-I      intronic chr11:35299939(-) A-I      intronic chr11:35280299(-) A-I      3'UTR chr11:35280323(-) A-I      3'UTR chr11:35383341(-) A-I      intronic chr11:35408590(-) A-I      intronic chr11:35377349(-) A-I      intronic chr11:35355247(-) A-I      intronic chr11:35373384(-) A-I      intronic chr11:35355315(-) A-I      intronic chr11:35354794(-) A-I      intronic chr11:35375814(-) A-I      intronic chr11:35300044(-) A-I      intronic chr11:35355324(-) A-I      intronic chr11:35354757(-) A-I      intronic chr11:35411220(-) A-I      intronic chr11:35299961(-) A-I      intronic chr11:35383313(-) A-I      intronic chr11:35408562(-) A-I      intronic chr11:35375883(-) A-I      intronic chr11:35320702(-) A-I      intronic chr11:35383306(-) A-I      intronic chr11:35290032(-) A-I      intronic chr11:35410104(-) A-I      intronic chr11:35286563(-) A-I      intronic chr11:35299960(-) A-I      intronic chr11:35382538(-) A-I      intronic chr11:35355372(-) A-I      intronic chr11:35408589(-) A-I      intronic chr11:35378599(-) A-I      intronic chr11:35408596(-) A-I      intronic chr11:35412210(-) A-I      intronic chr11:35284850(-) A-I      intronic chr11:35290149(-) A-I      intronic chr11:35370340(-) A-I      intronic chr11:35412302(-) A-I      intronic chr11:35416512(-) A-I      intronic chr11:35379629(-) A-I      intronic chr11:35410124(-) A-I      intronic chr11:35355498(-) A-I      intronic chr11:35290150(-) A-I      intronic chr11:35373346(-) A-I      intronic chr11:35280365(-) A-I      3'UTR chr11:35280410(-) A-I      3'UTR chr11:35280404(-) A-I      3'UTR chr11:35280338(-) A-I      3'UTR chr11:35280456(-) A-I      3'UTR chr11:35280232(-) A-I      3'UTR chr11:35280405(-) A-I      3'UTR chr11:35280244(-) A-I      3'UTR

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	SLC1A2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: SLC1A2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).