Basic Information:

  VIRBase ID:  

HHID00008124

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          PRRX1:  NM_022716     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	PRRX1
miRBase Accession/Entrez ID	MIMAT0004512	5396
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AGOTC//PHOX1//PMX1//PRX-1//PRX1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRRX1	chr1:170676068(+) A-I      intronic chr1:170676041(+) A-I      intronic chr1:170635504(+) A-I      intronic chr1:170635480(+) A-I      intronic chr1:170635465(+) A-I      intronic chr1:170635478(+) A-I      intronic chr1:170676145(+) A-I      intronic chr1:170676155(+) A-I      intronic chr1:170676172(+) A-I      intronic chr1:170676168(+) A-I      intronic chr1:170676220(+) A-I      intronic chr1:170674536(+) A-I      intronic chr1:170676206(+) A-I      intronic chr1:170669057(+) A-I      intronic chr1:170653732(+) A-I      intronic chr1:170669032(+) A-I      intronic chr1:170674523(+) A-I      intronic chr1:170632581(+) A-I      5'UTR chr1:170674563(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRRX1	chr1:170632304-170632305(+) m6A 5'UTR//intron       24981863 chr1:170632610-170632611(+) m6A 5'UTR//intron       24981863 chr1:170632703-170632704(+) m6A 5'UTR//intron       24981863 chr1:170632724-170632725(+) m6A 5'UTR//intron       24981863 chr1:170632769-170632770(+) m6A 5'UTR//intron       24981863 chr1:170632801-170632802(+) m6A 5'UTR//intron       24981863 chr1:170632827-170632828(+) m6A 5'UTR//intron       - chr1:170632865-170632866(+) m6A 5'UTR//intron       - chr1:170632991-170632992(+) m6A 5'UTR//intron       24981863 chr1:170633034-170633035(+) m6A 5'UTR//intron       24981863 chr1:170633084-170633085(+) m6A 5'UTR//intron       24981863 chr1:170633094-170633095(+) m6A 5'UTR//intron       24981863 chr1:170633417-170633418(+) m6A CDS//intron       24981863 chr1:170633456-170633457(+) m6A CDS//exon       24981863 chr1:170633480-170633481(+) m6A CDS//exon       24981863 chr1:170633498-170633499(+) m6A CDS//exon       24981863 chr1:170633565-170633566(+) m6A CDS//exon       24209618//24981863 chr1:170633597-170633598(+) m6A CDS//exon       24209618//24981863 chr1:170688878-170688879(+) m6A CDS//exon       24981863 chr1:170688919-170688920(+) m6A CDS//exon       24981863 chr1:170695500-170695501(+) m6A CDS//exon       24981863 chr1:170695525-170695526(+) m6A CDS//exon       24981863 chr1:170695659-170695660(+) m6A 3'UTR//intron       24981863 chr1:170695771-170695772(+) m6A 3'UTR//intron       24981863 chr1:170695779-170695780(+) m6A 3'UTR//intron       24981863 chr1:170695867-170695868(+) m6A 3'UTR//intron       24981863//22608085 chr1:170695872-170695873(+) m6A 3'UTR//intron       24981863//22608085 chr1:170695941-170695942(+) m6A 3'UTR//intron       24981863//22608085 chr1:170695966-170695967(+) m6A 3'UTR//intron       24981863//22608085 chr1:170695979-170695980(+) m6A 3'UTR//intron       24981863//22608085 chr1:170696060-170696061(+) m6A 3'UTR//intron       24981863//22608085 chr1:170699741-170699742(+) m6A exon//intron       - chr1:170705272-170705273(+) m6A 3'UTR//CDS//exon       24981863 chr1:170705304-170705305(+) m6A 3'UTR//CDS//exon       24981863 chr1:170705344-170705345(+) m6A 3'UTR//exon       24981863 chr1:170705367-170705368(+) m6A 3'UTR//exon       24981863 chr1:170705375-170705376(+) m6A 3'UTR//exon       24981863 chr1:170705431-170705432(+) m6A 3'UTR//exon       24981863 chr1:170705439-170705440(+) m6A 3'UTR//exon       24981863 chr1:170705449-170705450(+) m6A 3'UTR//exon       24981863 chr1:170705463-170705464(+) m6A 3'UTR//exon       24981863 chr1:170705950-170705951(+) m6A 3'UTR       24981863 chr1:170707696-170707697(+) m6A 3'UTR       24981863 chr1:170707713-170707714(+) m6A 3'UTR       24981863 chr1:170707719-170707720(+) m6A 3'UTR       24981863 chr1:170707759-170707760(+) m6A 3'UTR       24981863//22608085 chr1:170707818-170707819(+) m6A 3'UTR       24981863 chr1:170707859-170707860(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PRRX1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: PRRX1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).