Detail Information

Basic Information:


  VIRBase ID:  

HHID00008104

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           NFIB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p NFIB
miRBase
Accession/Entrez ID		 MIMAT0004512 4781
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CTF//HMGIC/NFIB//MACID//NF-I/B//NF1-B//NFI-B//NFI-RED//NFIB2//NFIB3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NFIB
chr9:14254104(-) A-I      intronic
chr9:14114634(-) A-I      intronic
chr9:14285246(-) A-I      intronic
chr9:14287174(-) A-I      intronic
chr9:14287495(-) A-I      intronic
chr9:14287665(-) A-I      intronic
chr9:14207990(-) A-I      intronic
chr9:14170469(-) A-I      intronic
chr9:14170497(-) A-I      intronic
chr9:14248051(-) A-I      intronic
chr9:14156009(-) A-I      intronic
chr9:14245864(-) A-I      intronic
chr9:14170486(-) A-I      intronic
chr9:14123144(-) A-I      intronic
chr9:14123134(-) A-I      intronic
chr9:14285393(-) A-I      intronic
chr9:14183541(-) A-I      intronic
chr9:14285394(-) A-I      intronic
chr9:14222745(-) A-I      intronic
chr9:14227078(-) A-I      intronic
chr9:14248047(-) A-I      intronic
chr9:14247935(-) A-I      intronic
chr9:14247927(-) A-I      intronic
chr9:14170594(-) A-I      intronic
chr9:14248146(-) A-I      intronic
chr9:14245866(-) A-I      intronic
chr9:14245785(-) A-I      intronic
chr9:14245650(-) A-I      intronic
chr9:14233566(-) A-I      intronic
chr9:14228326(-) A-I      intronic
chr9:14225393(-) A-I      intronic
chr9:14222712(-) A-I      intronic
chr9:14222711(-) A-I      intronic
chr9:14175402(-) A-I      intronic
chr9:14248121(-) A-I      intronic
chr9:14248115(-) A-I      intronic
chr9:14248109(-) A-I      intronic
chr9:14248088(-) A-I      intronic
chr9:14248070(-) A-I      intronic
chr9:14227077(-) A-I      intronic
chr9:14227057(-) A-I      intronic
chr9:14227054(-) A-I      intronic
chr9:14175378(-) A-I      intronic
chr9:14227040(-) A-I      intronic
chr9:14175369(-) A-I      intronic
chr9:14175337(-) A-I      intronic
chr9:14248160(-) A-I      intronic
chr9:14227032(-) A-I      intronic
chr9:14170520(-) A-I      intronic
chr9:14170519(-) A-I      intronic
chr9:14170458(-) A-I      intronic
chr9:14375412(-) A-I      intronic
chr9:14184864(-) A-I      intronic
chr9:14228362(-) A-I      intronic
chr9:14375485(-) A-I      intronic
chr9:14375400(-) A-I      intronic
chr9:14147808(-) A-I      intronic
chr9:14248408(-) A-I      intronic
chr9:14226425(-) A-I      intronic
chr9:14375475(-) A-I      intronic
chr9:14375431(-) A-I      intronic
chr9:14248060(-) A-I      intronic
chr9:14248134(-) A-I      intronic
chr9:14375574(-) A-I      intronic
chr9:14230076(-) A-I      intronic
chr9:14287560(-) A-I      intronic
chr9:14229937(-) A-I      intronic
chr9:14287640(-) A-I      intronic
chr9:14375575(-) A-I      intronic
chr9:14375626(-) A-I      intronic
chr9:14248010(-) A-I      intronic
chr9:14175249(-) A-I      intronic
chr9:14248543(-) A-I      intronic
chr9:14376141(-) A-I      intronic
chr9:14375605(-) A-I      intronic
chr9:14375600(-) A-I      intronic
chr9:14287508(-) A-I      intronic
chr9:14375610(-) A-I      intronic
chr9:14287599(-) A-I      intronic
chr9:14374784(-) A-I      intronic
chr9:14248132(-) A-I      intronic
chr9:14375492(-) A-I      intronic
chr9:14248372(-) A-I      intronic
chr9:14248024(-) A-I      intronic
chr9:14285315(-) A-I      intronic
chr9:14248043(-) A-I      intronic
chr9:14229938(-) A-I      intronic
chr9:14158027(-) A-I      intronic
chr9:14253608(-) A-I      intronic
chr9:14248112(-) A-I      intronic
chr9:14183683(-) A-I      intronic
chr9:14287490(-) A-I      intronic
chr9:14287542(-) A-I      intronic
chr9:14285325(-) A-I      intronic
chr9:14266558(-) A-I      intronic
chr9:14248053(-) A-I      intronic
chr9:14228292(-) A-I      intronic
chr9:14248107(-) A-I      intronic
chr9:14248029(-) A-I      intronic
chr9:14245703(-) A-I      intronic
chr9:14248056(-) A-I      intronic
chr9:14287603(-) A-I      intronic
chr9:14184785(-) A-I      intronic
chr9:14248496(-) A-I      intronic
chr9:14376128(-) A-I      intronic
chr9:14228266(-) A-I      intronic
chr9:14285182(-) A-I      intronic
chr9:14245789(-) A-I      intronic
chr9:14248108(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NFIB
chr9:14375400(-) A-I intron -    22028664
chr9:14375412(-) A-I intron -    22028664
chr9:14375431(-) A-I intron -    22028664
chr9:14375475(-) A-I intron -    22028664
chr9:14375485(-) A-I intron -    22028664
chr9:14375492(-) A-I intron -    22028664
chr9:14375574(-) A-I intron -    22028664
chr9:14375575(-) A-I intron -    22028664
chr9:14375600(-) A-I intron -    22028664
chr9:14375605(-) A-I intron -    22028664
chr9:14375610(-) A-I intron -    22028664
chr9:14375626(-) A-I intron -    22028664

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NFIB
chr9:14082684-14082685(-) m6A 3'UTR       24981863//27773535
chr9:14082695-14082696(-) m6A 3'UTR       24981863//27773535
chr9:14082716-14082717(-) m6A 3'UTR       24981863//27773535
chr9:14082832-14082833(-) m6A 3'UTR       27773535
chr9:14082846-14082847(-) m6A 3'UTR       27773535
chr9:14087448-14087449(-) m6A 3'UTR       24981863//27773535
chr9:14087545-14087546(-) m6A 3'UTR       24981863//27773535
chr9:14087554-14087555(-) m6A 3'UTR       24981863//27773535
chr9:14088023-14088024(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr9:14088069-14088070(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr9:14088090-14088091(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr9:14088116-14088117(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr9:14088121-14088122(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr9:14088126-14088127(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr9:14088183-14088184(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr9:14088206-14088207(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr9:14088225-14088226(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr9:14088238-14088239(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr9:14088278-14088279(-) m6A 3'UTR//CDS       24284625//24981863//27773535
chr9:14102490-14102491(-) m6A CDS//intron       24284625//27773535
chr9:14113022-14113023(-) m6A CDS//intron       27773535
chr9:14113036-14113037(-) m6A CDS//intron       27773535
chr9:14116228-14116229(-) m6A CDS//intron       27773535
chr9:14120446-14120447(-) m6A CDS       24284625//24981863//27773535
chr9:14120481-14120482(-) m6A CDS       24284625//24981863//27773535
chr9:14120608-14120609(-) m6A CDS       24284625//24981863//27773535
chr9:14125685-14125686(-) m6A CDS       24284625//24981863//27773535
chr9:14146708-14146709(-) m6A CDS       27773535
chr9:14150188-14150189(-) m6A CDS       27773535
chr9:14150246-14150247(-) m6A 5'UTR//CDS       27773535
chr9:14155842-14155843(-) m6A 5'UTR//CDS       27773535
chr9:14307073-14307074(-) m6A CDS       24981863//27773535
chr9:14307175-14307176(-) m6A CDS       24981863//27773535//22575960//22608085
chr9:14307277-14307278(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:14307312-14307313(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr9:14307342-14307343(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr9:14307970-14307971(-) m6A 5'UTR//intron       24284625//24209618
chr9:14307996-14307997(-) m6A 5'UTR//intron       24284625//24209618
chr9:14313666-14313667(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr9:14313693-14313694(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr9:14313734-14313735(-) Tm 5'UTR//intron       -
chr9:14313755-14313756(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr9:14313822-14313823(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr9:14313834-14313835(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr9:14313886-14313887(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535
chr9:14314029-14314030(-) m6A 5'UTR//intron       24284625//24981863
chr9:14314557-14314558(-) m6A 5'UTR//intron       24284625//24981863//27773535
chr9:14321977-14321978(-) m6A 5'UTR//intron       24284625//24981863
chr9:14322116-14322117(-) m6A 5'UTR//intron       24284625//25456834//27773535//22575960
chr9:14322156-14322157(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535//22575960
chr9:14322192-14322193(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535//22575960
chr9:14322219-14322220(-) m6A 5'UTR//intron       24284625//25456834//24981863//27773535//22575960
chr9:14322261-14322262(-) m6A 5'UTR//intron       24284625//25456834//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
NFIB
Chromatin K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: NFIB

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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