Detail Information

Basic Information:


  VIRBase ID:  

HHID00008083

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           KPNA4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p KPNA4
miRBase
Accession/Entrez ID		 MIMAT0004512 3840
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IPOA3//QIP1//SRP3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KPNA4
chr3:160220339(-) A-I      intronic
chr3:160220336(-) A-I      intronic
chr3:160242407(-) A-I      intronic
chr3:160264243(-) A-I      intronic
chr3:160242378(-) A-I      intronic
chr3:160264176(-) A-I      intronic
chr3:160264162(-) A-I      intronic
chr3:160264143(-) A-I      intronic
chr3:160264061(-) A-I      intronic
chr3:160264058(-) A-I      intronic
chr3:160242356(-) A-I      intronic
chr3:160221762(-) A-I      intronic
chr3:160221760(-) A-I      intronic
chr3:160221715(-) A-I      intronic
chr3:160261873(-) A-I      intronic
chr3:160220251(-) A-I      intronic
chr3:160220261(-) A-I      intronic
chr3:160220287(-) A-I      intronic
chr3:160220335(-) A-I      intronic
chr3:160220401(-) A-I      intronic
chr3:160220636(-) A-I      intronic
chr3:160220655(-) A-I      intronic
chr3:160220750(-) A-I      intronic
chr3:160220823(-) A-I      intronic
chr3:160220893(-) A-I      intronic
chr3:160221748(-) A-I      intronic
chr3:160225095(-) A-I      intronic
chr3:160225124(-) A-I      intronic
chr3:160225188(-) A-I      intronic
chr3:160229091(-) A-I      intronic
chr3:160230485(-) A-I      intronic
chr3:160230508(-) A-I      intronic
chr3:160230568(-) A-I      intronic
chr3:160230571(-) A-I      intronic
chr3:160231085(-) A-I      intronic
chr3:160231106(-) A-I      intronic
chr3:160233871(-) A-I      intronic
chr3:160233913(-) A-I      intronic
chr3:160233998(-) A-I      intronic
chr3:160234022(-) A-I      intronic
chr3:160234396(-) A-I      intronic
chr3:160234498(-) A-I      intronic
chr3:160234503(-) A-I      intronic
chr3:160236567(-) A-I      intronic
chr3:160239130(-) A-I      intronic
chr3:160239152(-) A-I      intronic
chr3:160239369(-) A-I      intronic
chr3:160239387(-) A-I      intronic
chr3:160239388(-) A-I      intronic
chr3:160241067(-) A-I      intronic
chr3:160242128(-) A-I      intronic
chr3:160242242(-) A-I      intronic
chr3:160242254(-) A-I      intronic
chr3:160246938(-) A-I      intronic
chr3:160246942(-) A-I      intronic
chr3:160246995(-) A-I      intronic
chr3:160250872(-) A-I      intronic
chr3:160250879(-) A-I      intronic
chr3:160250884(-) A-I      intronic
chr3:160250900(-) A-I      intronic
chr3:160252273(-) A-I      intronic
chr3:160261265(-) A-I      intronic
chr3:160261290(-) A-I      intronic
chr3:160261377(-) A-I      intronic
chr3:160261883(-) A-I      intronic
chr3:160264134(-) A-I      intronic
chr3:160264259(-) A-I      intronic
chr3:160214042(-) A-I      3'UTR
chr3:160214007(-) A-I      3'UTR
chr3:160213994(-) A-I      3'UTR
chr3:160214013(-) A-I      3'UTR
chr3:160213910(-) A-I      3'UTR
chr3:160213993(-) A-I      3'UTR
chr3:160213884(-) A-I      3'UTR
chr3:160213896(-) A-I      3'UTR
chr3:160238321(-) A-I      intronic
chr3:160234474(-) A-I      intronic
chr3:160220341(-) A-I      intronic
chr3:160230454(-) A-I      intronic
chr3:160239334(-) A-I      intronic
chr3:160261892(-) A-I      intronic
chr3:160221699(-) A-I      intronic
chr3:160252739(-) A-I      intronic
chr3:160252251(-) A-I      intronic
chr3:160231252(-) A-I      intronic
chr3:160225030(-) A-I      intronic
chr3:160234323(-) A-I      intronic
chr3:160246918(-) A-I      intronic
chr3:160220438(-) A-I      intronic
chr3:160220897(-) A-I      intronic
chr3:160241038(-) A-I      intronic
chr3:160252782(-) A-I      intronic
chr3:160220250(-) A-I      intronic
chr3:160252340(-) A-I      intronic
chr3:160221652(-) A-I      intronic
chr3:160215034(-) A-I      3'UTR
chr3:160214000(-) A-I      3'UTR
chr3:160214984(-) A-I      3'UTR
chr3:160220327(-) A-I      intronic
chr3:160231208(-) A-I      intronic
chr3:160246881(-) A-I      intronic
chr3:160220791(-) A-I      intronic
chr3:160231195(-) A-I      intronic
chr3:160234365(-) A-I      intronic
chr3:160242305(-) A-I      intronic
chr3:160233872(-) A-I      intronic
chr3:160220813(-) A-I      intronic
chr3:160220415(-) A-I      intronic
chr3:160236573(-) A-I      intronic
chr3:160221747(-) A-I      intronic
chr3:160233912(-) A-I      intronic
chr3:160221653(-) A-I      intronic
chr3:160261935(-) A-I      intronic
chr3:160238108(-) A-I      intronic
chr3:160225121(-) A-I      intronic
chr3:160221716(-) A-I      intronic
chr3:160238188(-) A-I      intronic
chr3:160264223(-) A-I      intronic
chr3:160252384(-) A-I      intronic
chr3:160220654(-) A-I      intronic
chr3:160241089(-) A-I      intronic
chr3:160228678(-) A-I      intronic
chr3:160220363(-) A-I      intronic
chr3:160252358(-) A-I      intronic
chr3:160241556(-) A-I      intronic
chr3:160220227(-) A-I      intronic
chr3:160246982(-) A-I      intronic
chr3:160220852(-) A-I      intronic
chr3:160221705(-) A-I      intronic
chr3:160220642(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KPNA4
chr3:160219827(-) A-I exon 3'UTR    22327324
chr3:160219837(-) A-I exon 3'UTR    22327324
chr3:160214000(-) A-G exon 3'UTR    22484847
chr3:160220227(-) A-G intron -    22484847
chr3:160220297(-) A-G intron -    22484847
chr3:160220326(-) A-G intron -    22484847
chr3:160220341(-) A-G intron -    22484847
chr3:160220438(-) A-G intron -    22484847
chr3:160220654(-) A-G intron -    22484847
chr3:160220852(-) A-G intron -    22484847
chr3:160220897(-) A-G intron -    22484847
chr3:160221764(-) A-G intron -    22484847
chr3:160228678(-) A-G intron -    22484847
chr3:160231192(-) A-G intron -    22484847
chr3:160231195(-) A-G intron -    22484847
chr3:160231208(-) A-G intron -    22484847
chr3:160233872(-) A-G intron -    22484847
chr3:160234438(-) A-G intron -    22484847
chr3:160236573(-) A-G intron -    22484847
chr3:160239334(-) A-G intron -    22484847
chr3:160239339(-) A-G intron -    22484847
chr3:160241038(-) A-G intron -    22484847
chr3:160241093(-) A-G intron -    22484847
chr3:160242391(-) A-G intron -    22484847
chr3:160252358(-) A-G intron -    22484847
chr3:160252384(-) A-G intron -    22484847
chr3:160261832(-) T-C intron -    22484847
chr3:160261892(-) A-G intron -    22484847
chr3:160261935(-) A-G intron -    22484847
chr3:160264088(-) A-G intron -    22484847
chr3:160273734(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KPNA4
chr3:160214238-160214239(-) m6A 3'UTR       27773535
chr3:160214298-160214299(-) m6A 3'UTR       27773535
chr3:160214447-160214448(-) m6A 3'UTR       27773535
chr3:160214553-160214554(-) m6A 3'UTR       27773535
chr3:160219173-160219174(-) m6A 3'UTR       24981863//22608085
chr3:160219189-160219190(-) m6A 3'UTR       24981863//22608085
chr3:160219195-160219196(-) m6A 3'UTR       24981863//22608085
chr3:160219564-160219565(-) m6A 3'UTR       24981863//27773535
chr3:160219641-160219642(-) m6A 3'UTR       24981863//27773535
chr3:160219778-160219779(-) Y 3'UTR       26075521
chr3:160233300-160233301(-) m6A CDS       -
chr3:160233316-160233317(-) m6A CDS       -
chr3:160233328-160233329(-) m6A CDS       -
chr3:160239624-160239625(-) m6A CDS       -
chr3:160239644-160239645(-) m6A CDS       -
chr3:160253623-160253624(-) m6A CDS       22575960
chr3:160253670-160253671(-) m6A CDS       24981863//22575960
chr3:160254616-160254617(-) m6A CDS       24209618//24981863
chr3:160282405-160282406(-) m6A exon//intron       24209618
chr3:160283020-160283021(-) m6A CDS//exon       24209618//24981863//27371828//27773536//22575960
chr3:160283047-160283048(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536//22575960
chr3:160283052-160283053(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536//22575960
chr3:160283062-160283063(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
KPNA4
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: KPNA4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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