Basic Information:

  VIRBase ID:  

HHID00008080

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          JAK2:  NR_169764     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	JAK2
miRBase Accession/Entrez ID	MIMAT0004512	3717
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	JTK10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JAK2	chr9:5102325(+) A-I      intronic chr9:5025674(+) A-I      intronic chr9:5025678(+) A-I      intronic chr9:5064281(+) A-I      intronic chr9:5102353(+) A-I      intronic chr9:5102375(+) A-I      intronic chr9:5120073(+) A-I      intronic chr9:5102378(+) A-I      intronic chr9:5102381(+) A-I      intronic chr9:5102389(+) A-I      intronic chr9:5120051(+) A-I      intronic chr9:5120066(+) A-I      intronic chr9:5064291(+) A-I      intronic chr9:5120089(+) A-I      intronic chr9:5120098(+) A-I      intronic chr9:5025742(+) A-I      intronic chr9:5025663(+) A-I      intronic chr9:5025608(+) A-I      intronic chr9:5085751(+) A-I      intronic chr9:5085772(+) A-I      intronic chr9:5085787(+) A-I      intronic chr9:5085806(+) A-I      intronic chr9:5112688(+) A-I      intronic chr9:5112689(+) A-I      intronic chr9:5112702(+) A-I      intronic chr9:5102318(+) A-I      intronic chr9:5102317(+) A-I      intronic chr9:5102328(+) A-I      intronic chr9:5102336(+) A-I      intronic chr9:5102351(+) A-I      intronic chr9:5112730(+) A-I      intronic chr9:5102331(+) A-I      intronic chr9:5025672(+) A-I      intronic chr9:4996305(+) A-I      intronic chr9:4996359(+) A-I      intronic chr9:4996380(+) A-I      intronic chr9:5021767(+) A-I      intronic chr9:5025627(+) A-I      intronic chr9:5102383(+) A-I      intronic chr9:5005212(+) A-I      intronic chr9:4996298(+) A-I      intronic chr9:4997041(+) A-I      intronic chr9:5042150(+) A-I      intronic chr9:5021764(+) A-I      intronic chr9:5021758(+) A-I      intronic chr9:5005188(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JAK2	chr9:4985095-4985096(+) m6A exon       24981863 chr9:5090814-5090815(+) m6A CDS       24981863 chr9:5090862-5090863(+) m6A CDS       24981863 chr9:5111064-5111065(+) m6A intron       - chr9:5111103-5111104(+) m6A intron       - chr9:5114531-5114532(+) m6A intron       - chr9:5114537-5114538(+) m6A intron       - chr9:5114567-5114568(+) m6A intron       - chr9:5114582-5114583(+) m6A intron       - chr9:5126813-5126814(+) m6A 3'UTR//exon       24981863 chr9:5126832-5126833(+) m6A 3'UTR//exon       24981863 chr9:5126861-5126862(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126934-5126935(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126981-5126982(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	JAK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: JAK2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).