Detail Information

Basic Information:


  VIRBase ID:  

HHID00008078

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           ITGB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p ITGB1
miRBase
Accession/Entrez ID		 MIMAT0004512 3688
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD29//FNRB//GPIIA//MDF2//MSK12//VLA-BETA//VLAB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ITGB1
chr10:33229190(-) A-I      intronic
chr10:33229151(-) A-I      intronic
chr10:33229092(-) A-I      intronic
chr10:33235845(-) A-I      intronic
chr10:33235841(-) A-I      intronic
chr10:33235840(-) A-I      intronic
chr10:33229191(-) A-I      intronic
chr10:33236049(-) A-I      intronic
chr10:33235975(-) A-I      intronic
chr10:33235974(-) A-I      intronic
chr10:33235970(-) A-I      intronic
chr10:33235936(-) A-I      intronic
chr10:33235932(-) A-I      intronic
chr10:33229106(-) A-I      intronic
chr10:33229104(-) A-I      intronic
chr10:33229141(-) A-I      intronic
chr10:33234415(-) A-I      intronic
chr10:33234501(-) A-I      intronic
chr10:33235942(-) A-I      intronic
chr10:33231655(-) A-I      intronic
chr10:33231564(-) A-I      intronic
chr10:33195338(-) A-I      intronic
chr10:33229211(-) A-I      intronic
chr10:33231757(-) A-I      intronic
chr10:33236044(-) A-I      intronic
chr10:33231648(-) A-I      intronic
chr10:33234362(-) A-I      intronic
chr10:33195333(-) A-I      intronic
chr10:33236043(-) A-I      intronic
chr10:33192117(-) A-I      intronic
chr10:33234337(-) A-I      intronic
chr10:33231613(-) A-I      intronic
chr10:33234342(-) A-I      intronic
chr10:33195314(-) A-I      intronic
chr10:33235909(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ITGB1
chr10:33189714-33189715(-) m6A 3'UTR       27773535
chr10:33189798-33189799(-) m6A 3'UTR       27773535
chr10:33190128-33190129(-) m6A 3'UTR       24981863
chr10:33190235-33190236(-) m6A 3'UTR       24284625//24981863
chr10:33190296-33190297(-) m6A 3'UTR       24284625
chr10:33190303-33190304(-) m6A 3'UTR       24284625
chr10:33190314-33190315(-) m6A 3'UTR       24284625
chr10:33200494-33200495(-) m6A CDS       22575960
chr10:33200919-33200920(-) m6A CDS       26404942//22575960
chr10:33200962-33200963(-) m6A CDS       24981863//26404942//22575960
chr10:33200989-33200990(-) m6A CDS       24981863//26404942//22575960
chr10:33201027-33201028(-) m6A CDS       24981863//26404942//22575960
chr10:33208834-33208835(-) m6A CDS       24981863//26404942//22575960
chr10:33209219-33209220(-) m6A CDS       26404942//22575960
chr10:33211237-33211238(-) m6A CDS       26404942//22575960
chr10:33211263-33211264(-) m6A CDS       26404942//22575960
chr10:33211608-33211609(-) m6A CDS       26404942//22575960
chr10:33211630-33211631(-) m6A CDS       26404942
chr10:33212557-33212558(-) m6A CDS       26404942
chr10:33212587-33212588(-) m6A CDS       26404942
chr10:33214870-33214871(-) m6A CDS       26404942//22575960
chr10:33214882-33214883(-) m6A CDS       26404942//22575960
chr10:33214949-33214950(-) m6A CDS//exon       24981863//26404942//22575960
chr10:33214954-33214955(-) m6A CDS//exon       24981863//26404942//22575960
chr10:33214970-33214971(-) m6A CDS//exon       24981863//26404942//22575960
chr10:33215013-33215014(-) m6A CDS//exon       24981863//26404942//22575960
chr10:33217032-33217033(-) m6A CDS//intron       24981863//22575960
chr10:33217069-33217070(-) m6A CDS//intron       22575960
chr10:33217119-33217120(-) m6A CDS//intron       26404942//22575960
chr10:33217149-33217150(-) m6A CDS//intron       24981863//26404942
chr10:33217180-33217181(-) m6A CDS//intron       24981863//26404942
chr10:33218756-33218757(-) Am CDS//intron       -
chr10:33218821-33218822(-) m6A CDS//exon       24981863//26404942//27773535
chr10:33224422-33224423(-) m6A 5'UTR//CDS//exon       24981863
chr10:33224456-33224457(-) m6A 5'UTR//CDS//exon       24981863
chr10:33224828-33224829(-) m6A 5'UTR//intron       24981863
chr10:33244574-33244575(-) m6A 5'UTR//intron       27773536
chr10:33246742-33246743(-) m6A 5'UTR//intron       24209618//24981863//27773536
chr10:33247121-33247122(-) m6A 5'UTR//exon//intron       24209618//25456834//24981863//27773536
chr10:33247496-33247497(-) m6A exon//intron       25456834//24981863//27773536
chr10:33247577-33247578(-) m6A exon//intron       24981863
chr10:33247586-33247587(-) m6A exon//intron       24981863
chr10:33247754-33247755(-) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ITGB1
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Endoplasmic reticulum U2OS cells     22679391
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: ITGB1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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