Detail Information

Basic Information:


  VIRBase ID:  

HHID00008037

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           FOXM1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p FOXM1
miRBase
Accession/Entrez ID		 MIMAT0004512 2305
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FKHL16//FOXM1A//FOXM1B//FOXM1C//HFH-11//HFH11//HNF-3//INS-1//MPHOSPH2//MPP-2//MPP2//PIG29//TRIDENT

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FOXM1
chr12:2971133(-) A-I      intronic
chr12:2971125(-) A-I      intronic
chr12:2971179(-) A-I      intronic
chr12:2971341(-) A-I      intronic
chr12:2972657(-) A-I      intronic
chr12:2973055(-) A-I      intronic
chr12:2978830(-) A-I      intronic
chr12:2980779(-) A-I      intronic
chr12:2971165(-) A-I      intronic
chr12:2982425(-) A-I      intronic
chr12:2979883(-) A-I      intronic
chr12:2969570(-) A-I      intronic
chr12:2982416(-) A-I      intronic
chr12:2979945(-) A-I      intronic
chr12:2979977(-) A-I      intronic
chr12:2971729(-) A-I      intronic
chr12:2982513(-) A-I      intronic
chr12:2971926(-) A-I      intronic
chr12:2971805(-) A-I      intronic
chr12:2982398(-) A-I      intronic
chr12:2980568(-) A-I      intronic
chr12:2971981(-) A-I      intronic
chr12:2982948(-) A-I      intronic
chr12:2972760(-) A-I      intronic
chr12:2973010(-) A-I      intronic
chr12:2972706(-) A-I      intronic
chr12:2979338(-) A-I      intronic
chr12:2978610(-) A-I      intronic
chr12:2982882(-) A-I      intronic
chr12:2971818(-) A-I      intronic
chr12:2972969(-) A-I      intronic
chr12:2980629(-) A-I      intronic
chr12:2971233(-) A-I      intronic
chr12:2978611(-) A-I      intronic
chr12:2980001(-) A-I      intronic
chr12:2979428(-) A-I      intronic
chr12:2971263(-) A-I      intronic
chr12:2971731(-) A-I      intronic
chr12:2980723(-) A-I      intronic
chr12:2971983(-) A-I      intronic
chr12:2972647(-) A-I      intronic
chr12:2971799(-) A-I      intronic
chr12:2980013(-) A-I      intronic
chr12:2978739(-) A-I      intronic
chr12:2976374(-) A-I      intronic
chr12:2982518(-) A-I      intronic
chr12:2979587(-) A-I      intronic
chr12:2979783(-) A-I      intronic
chr12:2978799(-) A-I      intronic
chr12:2969593(-) A-I      intronic
chr12:2969636(-) A-I      intronic
chr12:2971927(-) A-I      intronic
chr12:2971772(-) A-I      intronic
chr12:2978730(-) A-I      intronic
chr12:2978949(-) A-I      intronic
chr12:2980072(-) A-I      intronic
chr12:2980664(-) A-I      intronic
chr12:2980003(-) A-I      intronic
chr12:2978806(-) A-I      intronic
chr12:2971951(-) A-I      intronic
chr12:2971935(-) A-I      intronic
chr12:2969468(-) A-I      intronic
chr12:2982189(-) A-I      intronic
chr12:2978750(-) A-I      intronic
chr12:2971262(-) A-I      intronic
chr12:2969577(-) A-I      intronic
chr12:2979294(-) A-I      intronic
chr12:2980048(-) A-I      intronic
chr12:2971794(-) A-I      intronic
chr12:2980055(-) A-I      intronic
chr12:2979746(-) A-I      intronic
chr12:2971739(-) A-I      intronic
chr12:2979626(-) A-I      intronic
chr12:2976420(-) A-I      intronic
chr12:2971735(-) A-I      intronic
chr12:2971980(-) A-I      intronic
chr12:2979335(-) A-I      intronic
chr12:2980569(-) A-I      intronic
chr12:2972960(-) A-I      intronic
chr12:2973144(-) A-I      intronic
chr12:2978612(-) A-I      intronic
chr12:2982876(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FOXM1
chr12:2971927(-) A-I intron -    22327324
chr12:2971983(-) A-I intron -    22327324
chr12:2979335(-) A-I intron -    22327324
chr12:2969468(-) A-G intron -    22484847
chr12:2971799(-) A-G intron -    22484847
chr12:2971927(-) A-G intron -    22484847
chr12:2971935(-) A-G intron -    22484847
chr12:2971951(-) A-G intron -    22484847
chr12:2971976(-) T-C intron -    22484847
chr12:2971983(-) A-G intron -    22484847
chr12:2979335(-) A-G intron -    22484847
chr12:2979338(-) A-G intron -    22484847
chr12:2979708(-) T-C intron -    22484847
chr12:2980072(-) A-G intron -    22484847
chr12:2969593(-) A-G intron -    22484847
chr12:2971233(-) A-G intron -    22484847
chr12:2971262(-) A-G intron -    22484847
chr12:2971263(-) A-G intron -    22484847
chr12:2971731(-) A-G intron -    22484847
chr12:2971735(-) A-G intron -    22484847
chr12:2971739(-) A-G intron -    22484847
chr12:2971980(-) A-G intron -    22484847
chr12:2973056(-) T-C intron -    22484847
chr12:2978799(-) A-G intron -    22484847
chr12:2978806(-) A-G intron -    22484847
chr12:2979626(-) A-G intron -    22484847
chr12:2979783(-) A-G intron -    22484847
chr12:2980001(-) A-G intron -    22484847
chr12:2980003(-) A-G intron -    22484847
chr12:2980048(-) A-G intron -    22484847
chr12:2982518(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FOXM1
chr12:2966850-2966851(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr12:2966880-2966881(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr12:2967007-2967008(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085
chr12:2967023-2967024(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085
chr12:2967248-2967249(-) m6A 3'UTR//exon       24284625//22575960
chr12:2967254-2967255(-) m6A 3'UTR//exon       24284625//22575960
chr12:2967316-2967317(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr12:2967394-2967395(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr12:2967538-2967539(-) m6A 3'UTR//exon       24284625//24209618//22575960
chr12:2967570-2967571(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960//22608085
chr12:2967633-2967634(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr12:2967706-2967707(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr12:2967719-2967720(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr12:2967858-2967859(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr12:2967885-2967886(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr12:2967921-2967922(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr12:2968047-2968048(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2968055-2968056(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2968171-2968172(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2968193-2968194(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2968237-2968238(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2968297-2968298(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr12:2968307-2968308(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr12:2968356-2968357(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr12:2968454-2968455(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr12:2968559-2968560(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr12:2968670-2968671(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960
chr12:2968723-2968724(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr12:2968766-2968767(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr12:2968784-2968785(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr12:2973864-2973865(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr12:2973869-2973870(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr12:2973883-2973884(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr12:2974076-2974077(-) m6A exon//intron       27773535
chr12:2974557-2974558(-) m6A CDS//exon//intron       22575960
chr12:2975571-2975572(-) m6A 3'UTR//CDS//exon       22575960
chr12:2975608-2975609(-) m6A 3'UTR//CDS//exon       22575960
chr12:2977610-2977611(-) m6A exon//intron       27773535//22608085
chr12:2977625-2977626(-) m6A exon//intron       27773535//22608085
chr12:2977645-2977646(-) m6A exon//intron       27773535//22608085
chr12:2977792-2977793(-) m6A 3'UTR//CDS//exon       27773535
chr12:2977882-2977883(-) m6A 3'UTR//CDS//exon       27773535//22575960
chr12:2977902-2977903(-) m6A 3'UTR//CDS//exon       27773535//22575960
chr12:2981308-2981309(-) Gm CDS//exon//intron       -
chr12:2981333-2981334(-) m6A CDS//exon//intron       24284625//24209618//27773535//27371828//22575960
chr12:2983148-2983149(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:2983182-2983183(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:2983212-2983213(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983218-2983219(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983226-2983227(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983244-2983245(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983265-2983266(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983271-2983272(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983284-2983285(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:2983551-2983552(-) m6A CDS       24209618//27773535
chr12:2983565-2983566(-) m6A CDS       24209618//27773535
chr12:2983637-2983638(-) m6A CDS       24209618
chr12:2986202-2986203(-) m6A 5'UTR       24209618//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
FOXM1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: FOXM1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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