Basic Information:

  VIRBase ID:  

HHID00008019

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          DLX1:  NM_001038493     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	DLX1
miRBase Accession/Entrez ID	MIMAT0004512	1745
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DLX1	chr2:172950127-172950128(+) m6A 5'UTR//intron       24284625//22608085 chr2:172950151-172950152(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr2:172950158-172950159(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr2:172950216-172950217(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr2:172950251-172950252(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr2:172950264-172950265(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr2:172950298-172950299(+) m6A 5'UTR//exon//intron       24284625//24981863//22608085 chr2:172950340-172950341(+) m6A 5'UTR//exon       24284625//24981863//22608085 chr2:172950348-172950349(+) m6A 5'UTR//exon       24284625//24981863//22608085 chr2:172950390-172950391(+) m6A 5'UTR//exon       24284625//22608085 chr2:172950712-172950713(+) m6A CDS//exon       24284625 chr2:172951033-172951034(+) m6A exon//intron       24284625 chr2:172951039-172951040(+) m6A exon//intron       24284625 chr2:172951387-172951388(+) m6A CDS//exon//intron       - chr2:172951457-172951458(+) m6A CDS//exon//intron       24981863 chr2:172951498-172951499(+) m6A CDS//exon//intron       24284625 chr2:172951515-172951516(+) m6A CDS//exon//intron       24284625 chr2:172951565-172951566(+) m6A CDS//exon//intron       24284625 chr2:172951575-172951576(+) m6A CDS//exon//intron       24284625 chr2:172952749-172952750(+) m6A CDS//exon       24284625 chr2:172952866-172952867(+) m6A 3'UTR//CDS//exon       24284625 chr2:172953068-172953069(+) m6A 3'UTR//exon       24284625//22608085 chr2:172953086-172953087(+) m6A 3'UTR//exon       24284625//22608085 chr2:172953171-172953172(+) m6A 3'UTR//exon       24284625//22608085 chr2:172953236-172953237(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953257-172953258(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953296-172953297(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953310-172953311(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953315-172953316(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953321-172953322(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953507-172953508(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953588-172953589(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr2:172953860-172953861(+) m6A 3'UTR//exon       22608085 chr2:172953879-172953880(+) m6A 3'UTR//exon       22608085 chr2:172953951-172953952(+) m6A 3'UTR//exon       24981863//22608085 chr2:172953961-172953962(+) m6A 3'UTR//exon       22608085 chr2:172953996-172953997(+) m6A 3'UTR//exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	DLX1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: DLX1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).