Basic Information:

  VIRBase ID:  

HHID00007980

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          CAPZA2:  NM_006136     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	CAPZA2
miRBase Accession/Entrez ID	MIMAT0004512	830
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAPPA2//CAPZ

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPZA2	chr7:116533351(+) A-I      intronic chr7:116555312(+) A-I      intronic chr7:116554657(+) A-I      intronic chr7:116520861(+) A-I      intronic chr7:116555314(+) A-I      intronic chr7:116534255(+) A-I      intronic chr7:116533249(+) A-I      intronic chr7:116555242(+) A-I      intronic chr7:116509955(+) A-I      intronic chr7:116533370(+) A-I      intronic chr7:116520879(+) A-I      intronic chr7:116533302(+) A-I      intronic chr7:116555228(+) A-I      intronic chr7:116533240(+) A-I      intronic chr7:116533216(+) A-I      intronic chr7:116530725(+) A-I      intronic chr7:116534232(+) A-I      intronic chr7:116514910(+) A-I      intronic chr7:116515694(+) A-I      intronic chr7:116520891(+) A-I      intronic chr7:116534163(+) A-I      intronic chr7:116555151(+) A-I      intronic chr7:116554590(+) A-I      intronic chr7:116534341(+) A-I      intronic chr7:116534397(+) A-I      intronic chr7:116547769(+) A-I      intronic chr7:116528623(+) A-I      intronic chr7:116515792(+) A-I      intronic chr7:116515847(+) A-I      intronic chr7:116515857(+) A-I      intronic chr7:116516122(+) A-I      intronic chr7:116516173(+) A-I      intronic chr7:116516225(+) A-I      intronic chr7:116555339(+) A-I      intronic chr7:116556441(+) A-I      intronic chr7:116556490(+) A-I      intronic chr7:116556612(+) A-I      intronic chr7:116557518(+) A-I      intronic chr7:116554714(+) A-I      intronic chr7:116554671(+) A-I      intronic chr7:116521023(+) A-I      intronic chr7:116555103(+) A-I      intronic chr7:116556625(+) A-I      intronic chr7:116554695(+) A-I      intronic chr7:116510027(+) A-I      intronic chr7:116515045(+) A-I      intronic chr7:116504844(+) A-I      intronic chr7:116520943(+) A-I      intronic chr7:116515809(+) A-I      intronic chr7:116515798(+) A-I      intronic chr7:116533368(+) A-I      intronic chr7:116515880(+) A-I      intronic chr7:116555278(+) A-I      intronic chr7:116515873(+) A-I      intronic chr7:116557438(+) A-I      intronic chr7:116554782(+) A-I      intronic chr7:116516210(+) A-I      intronic chr7:116557585(+) A-I      intronic chr7:116547755(+) A-I      intronic chr7:116547724(+) A-I      intronic chr7:116548222(+) A-I      intronic chr7:116528749(+) A-I      intronic chr7:116528809(+) A-I      intronic chr7:116534254(+) A-I      intronic chr7:116504859(+) A-I      intronic chr7:116505871(+) A-I      intronic chr7:116533259(+) A-I      intronic chr7:116528642(+) A-I      intronic chr7:116515645(+) A-I      intronic chr7:116516183(+) A-I      intronic chr7:116554655(+) A-I      intronic chr7:116554709(+) A-I      intronic chr7:116554616(+) A-I      intronic chr7:116554538(+) A-I      intronic chr7:116554785(+) A-I      intronic chr7:116555296(+) A-I      intronic chr7:116521539(+) A-I      intronic chr7:116508709(+) A-I      intronic chr7:116520901(+) A-I      intronic chr7:116555267(+) A-I      intronic chr7:116521024(+) A-I      intronic chr7:116520862(+) A-I      intronic chr7:116515023(+) A-I      intronic chr7:116555236(+) A-I      intronic chr7:116548113(+) A-I      intronic chr7:116507818(+) A-I      intronic chr7:116520510(+) A-I      intronic chr7:116547770(+) A-I      intronic chr7:116533285(+) A-I      intronic chr7:116554595(+) A-I      intronic chr7:116547718(+) A-I      intronic chr7:116528814(+) A-I      intronic chr7:116556569(+) A-I      intronic chr7:116531839(+) A-I      intronic chr7:116528657(+) A-I      intronic chr7:116556530(+) A-I      intronic chr7:116556501(+) A-I      intronic chr7:116514909(+) A-I      intronic chr7:116528783(+) A-I      intronic chr7:116555094(+) A-I      intronic chr7:116557448(+) A-I      intronic chr7:116554642(+) A-I      intronic chr7:116505836(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAPZA2	chr7:116504819(+) A-I intron -    21960545 chr7:116505870(+) A-I intron -    21960545 chr7:116547724(+) A-I intron -    21960545 chr7:116547755(+) A-I intron -    21960545 chr7:116547756(+) A-I intron -    21960545 chr7:116504860(+) A-G intron -    22484847 chr7:116508512(+) C-G intron -    22484847 chr7:116514909(+) A-G intron -    22484847 chr7:116515022(+) A-G intron -    22484847 chr7:116515023(+) A-G intron -    22484847 chr7:116515624(+) A-G intron -    22484847 chr7:116515740(+) A-G intron -    22484847 chr7:116515798(+) A-G intron -    22484847 chr7:116515809(+) A-G intron -    22484847 chr7:116516183(+) A-G intron -    22484847 chr7:116516210(+) A-G intron -    22484847 chr7:116520510(+) A-G intron -    22484847 chr7:116520855(+) A-G intron -    22484847 chr7:116520901(+) A-G intron -    22484847 chr7:116520952(+) A-G intron -    22484847 chr7:116521538(+) A-G intron -    22484847 chr7:116521539(+) A-G intron -    22484847 chr7:116533259(+) A-G intron -    22484847 chr7:116533285(+) A-G intron -    22484847 chr7:116533368(+) A-G intron -    22484847 chr7:116533387(+) A-G intron -    22484847 chr7:116533414(+) A-G intron -    22484847 chr7:116533435(+) A-G intron -    22484847 chr7:116534251(+) A-G intron -    22484847 chr7:116534254(+) A-G intron -    22484847 chr7:116534260(+) A-G intron -    22484847 chr7:116534348(+) A-G intron -    22484847 chr7:116548222(+) A-G intron -    22484847 chr7:116554642(+) A-G intron -    22484847 chr7:116555278(+) A-G intron -    22484847 chr7:116556493(+) A-G intron -    22484847 chr7:116556501(+) A-G intron -    22484847 chr7:116556530(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPZA2	chr7:116502595-116502596(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863 chr7:116513779-116513780(+) m6A exon//intron       24209618//25456834//24981863 chr7:116513821-116513822(+) m6A exon//intron       24981863 chr7:116528302-116528303(+) m6A exon//intron       27773535 chr7:116543381-116543382(+) Gm intron       16381836 chr7:116543382-116543383(+) Gm intron       16381836 chr7:116557874-116557875(+) m6A 3'UTR//CDS       24981863 chr7:116557926-116557927(+) m6A 3'UTR       24284625//24981863 chr7:116557989-116557990(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CAPZA2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: CAPZA2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).