Detail Information

Basic Information:


  VIRBase ID:  

HHID00007955

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           ALDH1A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p ALDH1A1
miRBase
Accession/Entrez ID		 MIMAT0004512 216
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ALDC//ALDH-E1//ALDH1//ALDH11//HEL-9//HEL-S-53e//HEL12//PUMB1//RALDH1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ALDH1A1
chr9:75533899(-) A-I      intronic
chr9:75524239(-) A-I      intronic
chr9:75524294(-) A-I      intronic
chr9:75524273(-) A-I      intronic
chr9:75524234(-) A-I      intronic
chr9:75524215(-) A-I      intronic
chr9:75524297(-) A-I      intronic
chr9:75524288(-) A-I      intronic
chr9:75524238(-) A-I      intronic
chr9:75548984(-) A-I      intronic
chr9:75524346(-) A-I      intronic
chr9:75524140(-) A-I      intronic
chr9:75548963(-) A-I      intronic
chr9:75524214(-) A-I      intronic
chr9:75524175(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ALDH1A1
chr9:75516045-75516046(-) m6A 3'UTR       26404942
chr9:75516130-75516131(-) m6A CDS       26404942
chr9:75516158-75516159(-) m6A CDS       26404942
chr9:75520875-75520876(-) m6A CDS       26404942
chr9:75524524-75524525(-) m6A CDS       26404942
chr9:75524568-75524569(-) m6A CDS       26404942
chr9:75524610-75524611(-) m6A CDS       26404942
chr9:75524666-75524667(-) m6A CDS       26404942
chr9:75526972-75526973(-) m6A CDS       26404942
chr9:75527026-75527027(-) m6A CDS       26404942
chr9:75532016-75532017(-) m6A CDS//intron       26404942
chr9:75538794-75538795(-) m6A exon//intron       26404942
chr9:75538962-75538963(-) m6A CDS//exon//intron       26404942
chr9:75540440-75540441(-) m6A CDS//exon       26404942
chr9:75540453-75540454(-) m6A CDS//exon       26404942
chr9:75542061-75542062(-) m6A CDS//exon       26404942
chr9:75542067-75542068(-) m6A CDS//exon       26404942
chr9:75543864-75543865(-) m6A CDS//exon       26404942
chr9:75543910-75543911(-) m6A CDS//exon       26404942
chr9:75545902-75545903(-) m6A CDS//exon       26404942
chr9:75555157-75555158(-) m6A CDS//exon       24981863//26404942//27773535
chr9:75567893-75567894(-) m6A CDS       24981863//26404942//27773535
chr9:75567962-75567963(-) m6A 5'UTR//intron       24981863//26404942//27773535
chr9:75653513-75653514(-) m6A 5'UTR//intron       24981863//26404942
chr9:75669136-75669137(-) m6A exon//intron       24981863
chr9:75695315-75695316(-) m6A 5'UTR       24981863
chr9:75695326-75695327(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ALDH1A1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: ALDH1A1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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