Detail Information

Basic Information:


  VIRBase ID:  

HHID00007951

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           ACVR1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p ACVR1
miRBase
Accession/Entrez ID		 MIMAT0004512 90
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACTRI//ACVR1A//ACVRLK2//ALK2//FOP//SKR1//TSRI

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ACVR1
chr2:158719738(-) A-I      intronic
chr2:158681414(-) A-I      intronic
chr2:158681452(-) A-I      intronic
chr2:158681404(-) A-I      intronic
chr2:158719701(-) A-I      intronic
chr2:158719692(-) A-I      intronic
chr2:158719685(-) A-I      intronic
chr2:158681454(-) A-I      intronic
chr2:158681462(-) A-I      intronic
chr2:158681453(-) A-I      intronic
chr2:158681459(-) A-I      intronic
chr2:158680795(-) A-I      intronic
chr2:158681451(-) A-I      intronic
chr2:158681430(-) A-I      intronic
chr2:158719681(-) A-I      intronic
chr2:158720184(-) A-I      intronic
chr2:158707431(-) A-I      intronic
chr2:158675808(-) A-I      intronic
chr2:158720971(-) A-I      intronic
chr2:158720953(-) A-I      intronic
chr2:158720616(-) A-I      intronic
chr2:158720938(-) A-I      intronic
chr2:158720569(-) A-I      intronic
chr2:158720483(-) A-I      intronic
chr2:158720127(-) A-I      intronic
chr2:158720101(-) A-I      intronic
chr2:158720087(-) A-I      intronic
chr2:158720052(-) A-I      intronic
chr2:158720046(-) A-I      intronic
chr2:158720043(-) A-I      intronic
chr2:158719695(-) A-I      intronic
chr2:158720950(-) A-I      intronic
chr2:158719662(-) A-I      intronic
chr2:158719657(-) A-I      intronic
chr2:158711468(-) A-I      intronic
chr2:158711439(-) A-I      intronic
chr2:158719952(-) A-I      intronic
chr2:158720152(-) A-I      intronic
chr2:158711912(-) A-I      intronic
chr2:158719707(-) A-I      intronic
chr2:158720171(-) A-I      intronic
chr2:158711710(-) A-I      intronic
chr2:158687549(-) A-I      intronic
chr2:158715150(-) A-I      intronic
chr2:158687522(-) A-I      intronic
chr2:158719964(-) A-I      intronic
chr2:158721005(-) A-I      intronic
chr2:158720871(-) A-I      intronic
chr2:158620762(-) A-I      intronic
chr2:158720097(-) A-I      intronic
chr2:158690728(-) A-I      intronic
chr2:158720207(-) A-I      intronic
chr2:158687560(-) A-I      intronic
chr2:158720861(-) A-I      intronic
chr2:158720925(-) A-I      intronic
chr2:158719653(-) A-I      intronic
chr2:158711388(-) A-I      intronic
chr2:158719606(-) A-I      intronic
chr2:158719684(-) A-I      intronic
chr2:158722156(-) A-I      intronic
chr2:158719748(-) A-I      intronic
chr2:158720977(-) A-I      intronic
chr2:158720477(-) A-I      intronic
chr2:158720469(-) A-I      intronic
chr2:158719737(-) A-I      intronic
chr2:158720017(-) A-I      intronic
chr2:158720100(-) A-I      intronic
chr2:158713545(-) A-I      intronic
chr2:158720065(-) A-I      intronic
chr2:158720162(-) A-I      intronic
chr2:158719689(-) A-I      intronic
chr2:158720126(-) A-I      intronic
chr2:158720205(-) A-I      intronic
chr2:158720146(-) A-I      intronic
chr2:158719669(-) A-I      intronic
chr2:158720109(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACVR1
chr2:158592973-158592974(-) m6A 3'UTR       27773535
chr2:158593049-158593050(-) m6A 3'UTR       27773535
chr2:158593214-158593215(-) m6A 3'UTR       27773535
chr2:158593276-158593277(-) m6A 3'UTR       27773535
chr2:158593679-158593680(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr2:158593695-158593696(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr2:158593766-158593767(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593775-158593776(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593799-158593800(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593810-158593811(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593828-158593829(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593844-158593845(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593873-158593874(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593881-158593882(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158593986-158593987(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:158594053-158594054(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:158594092-158594093(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:158594117-158594118(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr2:158594955-158594956(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr2:158594979-158594980(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr2:158617431-158617432(-) m6A CDS       27773535
chr2:158617487-158617488(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ACVR1
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: ACVR1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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