Detail Information

Basic Information:


  VIRBase ID:  

HHID00007945

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           COLCA1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p COLCA1
miRBase
Accession/Entrez ID		 MIMAT0004512 399948
Organism Homo sapiens Homo sapiens
Category miRNA lncRNA
Alias - C11orf92//CASC12//LOH11CR1F

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G
Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 COLCA1
rs12296076 chr11:111295779 G/A         20610541
rs10891246 chr11:111299815 A/G         22132133
rs10789822 chr11:111291966 A/G         23722424
rs4608113 chr11:111301454 C/T         23722424
rs6589220 chr11:111302565 C/T         23722424
rs3802842 chr11:111300984 C/A         24836286

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase COLCA1
chr11:111169071-111169072(-) m6A exon       27773535
chr11:111169081-111169082(-) m6A exon       27773535
chr11:111175655-111175656(-) m6A exon       -
chr11:111175671-111175672(-) m6A exon       -
chr11:111175730-111175731(-) m6A exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
COLCA1
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Resource Symbol Drug Name PubChem ID
RNAactDrug COLCA1
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Piperidine, 2-methyl-6-undecyl-       99090
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide       9874913
Osi-930       9868037
5Z-7-Oxozeaenol       9863776
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-YL)-3-methyl-1H-pyrazol-5-YL]-6-ethylbenzene-1,3-diol       984170
Midostaurin       9829523
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
17-(O-(2-Pyrrolidinoethyl)]oximino-5-androsten-3beta-ol       9571964
N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide       87517
Phenformin       8249
Bexarotene       82146
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
Sellowin A       73589
Neplanocin A       72968
Daniquidone       71750
Decafluorobenzophenone       70068
Carbamodithioic acid, dimethyl-, 2,4-dinitrophenyl ester       6967
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Panobinostat       6918837
Belinostat       6918638
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454
Temsirolimus       6918289
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Sulbentine       67686
Andrastin A       6712564
Neocuproine       65237
Tanespimycin       6505803
3-[[4-Methyl-1-piperazinyl]methyl]rifamycin       6450839
Ispinesib mesylate       6450816
Pelitinib       6445562
Piperlongumine       637858
Rifamycin       6324616
Cytarabine       6253
Irinotecan       60838
Topotecan       60700
Ceritinib       57379345
4-(2,4-Dinitrophenyl)sulfanyl-1-methyl-2-nitrobenzene       57359203
1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337
Dimethyloxalylglycine       560326
11-Methoxycarbonylmethylen-11H-indolo[1,2-a]indazole       5472499
Kendomycin       5472093
N-(1E-Pentenyl)-2Z,4Z-heptadienamide       5471986
Artelasticin       5471311
Gab-geldanamycin       5467747
Lfm-a13       54676905
[3-Keto-Bmt(sup 1)]-[Val(sup 2)]-Cyclosporin       5467197
Sungucin       54600645
Trunculin A       5459125
Erlancorin       5458808
[(3Ar,4R,6R,7S,9S,10Z,11aR)-6,7,9-trihydroxy-6,10-dimethyl-3-methylidene-2-oxo-4,5,7,8,9,11a-hexahydro-3aH-cyclodeca[b]furan-4-yl] (Z)-2-methylbut-2-enoate       5458727
Thiram       5455
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one       5382674
Benzonitrile, 4-(3-oxo-3-phenyl-1-propenyl)-       5367161
Bleomycin a2       5360373
Hydrogeldanamycin-18,21-diacetate       5358471
Crassin       5357909
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Bosutinib       5328940
3-[[2-[[1-[2-(Dimethylamino)acetyl]-6-methoxy-3,4-dihydro-2H-quinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-N-methylpyridine-2-carboxamide       53239988
Vorinostat       5311
Eriolangin       5281445
8-Hydroxymanzamine A       5270765
Bis(2-hydroxy-1-naphthyl) disulfide       521106
Alsterpaullone       5005498
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498559
Tubastatin A       49850262
Alectinib       49806720
Shikonin       479503
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
Ethoxycurcumin trithiadiazolaminomethylcarbonte       45028266
5-Epi-phomopsolide D       45028011
Epothilone B       448013
Ergosterol       444679
Dabrafenib       44462760
Cyclamin       441916
Refametinib       44182295
(3S,8S,9R,10R,13R,14S,17R)-17-[(2R)-5,6-Dihydroxy-6-methylheptan-2-yl]-3-hydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one       441813
2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid       44137675
Benzofurazan, 7-(4-benzyl-1-piperazinyl)-4-nitro-, 1-oxide       43795
Triacetyl crambescidin 800 hydrochloride       400721
2,2-Bis[4-(4-aminophenoxy)phenyl]adamantane       399966
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]-       397601
2H-1-Benzopyran-3-carboxamide, 2-imino-N-(1-adamantyl)-       397086
Bis(4-methylpiperazin-1-yl)methanethione       388906
Withafastuosin D diacetate       388300
Stereoisomer of NSC 674066-O       384359
N'-(1-Nitroacridin-9-yl)propane-1,3-diamine       378853
2,3,6-Tribromo-7-chloro-3,7-dimethyloct-1-ene       377930
2-(1-Piperazino)naphthazarin       376949
23-(Dimethylamino)-4,8,22,24-tetrahydroxy-1,12-dimethyl-20,25-dioxahexacyclo[19.3.1.02,19.05,18.07,16.09,14]pentacosa-2,4,7(16),8,10,12,14,18-octaene-6,17-dione       3751252
N-Hydroxy-N-methylpropanethioamide       371713
Etoposide       36462
3-(1-Adamantylamino)-1-phenylpropane       363844
Promoline       362574
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170
1,5-Dihydroxy-1,5-dipyridin-3-ylpentan-3-one       356571
2-Benzoylaminobenzamide, N-thiazol-2-yl-       355710
2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide       3463933
5-Fluorouracil       3385
Ehretinine       336435
Predorine       333830
Embelin       3218
N,N'-Bis(3-methoxyacridin-9-yl)hexane-1,6-diamine       319095
Butanedioic acid, 2-bromo-3-fluoro-, dimethyl ester       317895
Methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate       3005532
Elesclomol       300471
6-Bromotoyocamycin       270861
7-Methyljuglone       26905
D-Arabinose, 5-O-trityl-tribenzoate       265952
Cupric diethyldithiocarbamate       26180
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
4-Fluoro-2-[(2-{[2-methoxy-4-(1-propylpiperidin-3-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide       25218600
2-{[2-({5-[2-(Dimethylamino)acetamido]-2-methoxy-4-methylphenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluorobenzamide       25211574
3-[(2-{[1-(N,N-Dimethylglycyl)-6-Methoxy-4,4-Dimethyl-1,2,3,4-Tetrahydroquinolin-7-Yl]amino}-7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)amino]thiophene-2-Carboxamide       25210972
Brucine, dihydro-       251913
Omipalisib       25167777
Ruxolitinib       25126798
Navitoclax       24978538
Quizartinib       24889392
[(7R,13R,17R)-17-[2-[2-(Diethylamino)ethoxy]ethyl]-7,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfamate       24848393
Hydrazine sulfate       24842
Ponatinib       24826799
Cudc-101       24756910
Diisopropoxybis(chinoline-8-olato)titanium(IV)       24202322
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
2,5-Cyclohexadien-1-one, 2,6-dibromo-4-[(4-hydroxyphenyl)imino]-, sodium salt       23686434
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide       23635154
Aristolochic acid       2236
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione       20835084
Trichoderonin       20806
8-Hydroxyquinoline       1923
Erlotinib       176870
Gsk-690693       16725726
Obatoclax mesylate       16681698
Bradykinin Antagonist       16134278
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
Tipifarnib       159324
2-[4-(7-Chloroquinoxalin-2-yl)oxyphenoxy]propanoic acid       148183
Docetaxel       148124
8-Chloroadenosine       147569
Talazoparib       135565082
Butylcycloheptylprodiginine hydrochloride       135539743
Luminespib       135539077
Antineoplastic-353527       135502336
Cytallene       135436546
Osi-027       135398516
Akt inhibitor VIII       135398501
Methotrexate       126941
Lestaurtinib       126565
1,4-Naphthalenedione, 5-methoxy-       123220
Dactolisib       11977753
PF-00562271 free base       11713159
Trametinib       11707110
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
Crizotinib       11626560
Serdemetan       11609586
N-[4-(2-Tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide       11455910
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033
Amuvatinib       11282283
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole       11162021
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
Pareitropone       10469514
6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol       10170
2'-Deoxy-2'-fluorocytidine       101507
Selumetinib       10127622
Pazopanib       10113978
1,3-Benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile       10109823
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
9-Phenoxyacridine       100640
PDK1 inhibitor AR-12       10027278
1,2-cyclohexanediamine, platinum complex (9ci)       -
;1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1...       -
1,3-dithiolo[3,4-d]pyrimidine-2-thione, 5,7-dichloro-       -
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci)       -
1h-1,4,7-triazonine-1,4,7-triacetic acid, octahydro-       -
1h-imidazole-4,5-dicarboxylic acid, 2-phenyl- (9ci)       -
(3r,6'rs)-3-hydroxy-.beta.,.epsilon.-caroten-3-one       -
4,7-[bis-n,n'-(3-amino-9-thioacetamido)-acridine]-biphenyl       -
4-morpholinecarbodithioic acid, antimony complex       -
acetonitrile, 1,3-dithietan-2-ylidenenitro-       -
alkaloid isolated from west african medicinal plant       -
antineoplastic-641296       -
antineoplastic-641297       -
Asparaginase       -
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide       -
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide       -
bis(2-nitrophenyl)sulfilimine       -
Bleomycin (50 uM)       -
Cisplatin       -
[co(me2dtc)2(dee)]clo4       -
diindolo[2,3-a:3,2-h]quinolizine       -
;(E)-1-(4-methoxyphenyl)-3-(2-(3,4,5-trimethoxyphenylami...       -
;(E)-5-chloro-3-((6-(4-chlorophenyl)-2-cyclopropylimidaz...       -
ellipticine, 6-(3-aminopropyl)-9-methoxy-, dihydrochloride       -
ellipticine, 6-(3-aminopropyl)-, dihydrochloride       -
imidazole-5-one deri.       -
JQ12       -
MPS-1-IN-1       -
;N-(1-benzyl-2-methyl-1H-benzimidazol-5-yl)-N'-(4-fluoro...       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]-       -
protein toxin a 23 - mw approx. 6700       -
protein toxin d 5 - mw approx 6700       -
ptmc       -
pyrazoline derivative       -
SB52334       -
THZ-2-102-1       -
TL-1-85       -
TL-2-105       -
toxin .delta.53l       -
trichlorotris(4-tert-butylpyridine)ruthenium(iii)       -
WZ3105       -
XMD13-2       -
XMD14-99       -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: COLCA1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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