Basic Information:

  VIRBase ID:  

HHID00007944

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          LINC00999:  NR_024497     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	LINC00999
miRBase Accession/Entrez ID	MIMAT0004512	399744
Organism	Homo sapiens	Homo sapiens
Category	miRNA	lncRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

Resource	Symbol	SNP ID	SNP Position	Ref/Alt	PMID
LincSNP 3.0	LINC00999	rs2804649 chr10:38448326 C/T         17873874

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LINC00999	chr10:38717083(+) A-I      ncRNA chr10:38729112(+) A-I      intronic chr10:38728857(+) A-I      intronic chr10:38721674(+) A-I      intronic chr10:38718218(+) A-I      intronic chr10:38732340(+) A-I      intronic chr10:38729364(+) A-I      intronic chr10:38721607(+) A-I      intronic chr10:38721593(+) A-I      intronic chr10:38721547(+) A-I      intronic chr10:38730490(+) A-I      intronic chr10:38721542(+) A-I      intronic chr10:38728955(+) A-I      intronic chr10:38721047(+) A-I      intronic chr10:38720964(+) A-I      intronic chr10:38720943(+) A-I      intronic chr10:38719960(+) A-I      intronic chr10:38718134(+) A-I      intronic chr10:38718124(+) A-I      intronic chr10:38718107(+) A-I      intronic chr10:38729358(+) A-I      intronic chr10:38719982(+) A-I      intronic chr10:38733097(+) A-I      intronic chr10:38729356(+) A-I      intronic chr10:38729257(+) A-I      intronic chr10:38729223(+) A-I      intronic chr10:38724116(+) A-I      ncRNA chr10:38719989(+) A-I      intronic chr10:38719976(+) A-I      intronic chr10:38718235(+) A-I      intronic chr10:38734879(+) A-I      intronic chr10:38724235(+) A-I      intronic chr10:38717661(+) A-I      intronic chr10:38717691(+) A-I      intronic chr10:38729005(+) A-I      intronic chr10:38721597(+) A-I      intronic chr10:38722808(+) A-I      intronic chr10:38722846(+) A-I      intronic chr10:38729365(+) A-I      intronic chr10:38720023(+) A-I      intronic chr10:38717662(+) A-I      intronic chr10:38733061(+) A-I      intronic chr10:38735662(+) A-I      intronic chr10:38730469(+) A-I      intronic chr10:38724230(+) A-I      intronic chr10:38720022(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LINC00999	chr10:38736615-38736616(+) m6A 3'UTR       24981863 chr10:38736775-38736776(+) m6A 3'UTR       24981863 chr10:38736799-38736800(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LINC00999	Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	LINC00999	2-(((5-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)acetonitrile       9873849 9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846 6-Benzylthioinosine       95263 Tiotixene       941651 Acridine Yellow G       8672 Sulfonaphtholazoresorcinol       85517 Benzethonium chloride       8478 3-Hydroxy-4-(phenylazo)-2-naphthoic acid       80753 3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride       75442 Cyclopentenyl cytosine       72828 Panobinostat       6918837 Brigatinib       68165256 Triciribine       65399 2-Pyridinecarboxaldehyde, 2-quinolinylhydrazone       6436860 Phylanthoside       6436218 Citreoviridin       6436023 4-(N-Hydroxyacetamido)stilbene       6433723 Irinotecan       60838 Topotecan       60700 5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803 l-685,458       5479543 Phyllanthastatin 1       5477587 3-Bromo-4-N,N-bis-2'-cyanoethylaminobenzylidene rhodanine       5469596 Viridenomycin       54686463 Mito-tempol       54613387 Olivomycin Transformation       54610760 Eupalmerin acetate       5459169 Sulfaquinoxaline       5338 Palbociclib       5330286 N-(2-Methoxyphenyl)-5-phenyl-1,3-oxazol-2-amine       5329844 Alsterpaullone       5005498 Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498558 Okadaic acid       446512 Ouabain       439501 Cinerubin A hydrochloride       428786 Vemurafenib       42611257 Ptilomycalin A format salt       395755 6-(Benzyloxy)-5-bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one       376767 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170 4-Methyl-2-{2-[(pyridin-2-yl)methylidene]hydrazin-1-yl}quinoline       332903 4-(3,12-Dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pentanoic acid       302 AT 116, benzylamine salt       282523 2-(6-Phenanthridinylthio)-1-phenylethanone       264067 6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600 Sorafenib       216239 8-Amino-5-methyl-6-phenylphenanthridin-5-ium bromide       21144180 Kinetin riboside       20345 8-Chloro-cyclicamp       17856967 Mercury, (acetyloxy)(pentamethylphenyl)-       16683786 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 8-Chloroadenosine       147569 Homidium bromide       14710 Basic violet 2       14454445 Berberine chloride       12456 (Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261 Crizotinib       11626560 Pararosaniline hydrochloride       11292 Setoglaucine       107404 Pha-665752       10461815 25-Dihydrosaframycin A       100180 9-(2-Amino-2-deoxy-d-xylofuranosyl) adenine       100053 1,4-dimethoxy-7-azaisoindole[2,1-a]quinoxalin-6(5h)-one       - ;(1R,6S,11aS,13S,14aR)-6-ethyl-1,13-dihydroxy-1,6,7,8,9,...       - 5,6-ethylenediquino[3,2-b       - .alpha.-sarcin       - Basic Fuchsin       - benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 3-methyl-       - benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       - crotoxin cd       - gramicidin       - hydroxyprogesterone caproate (usan)       - naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)-       - naphtho[2,1-b]quinolizinium, 5-chloro-7-methyl- perchlorate       - naphtho[2,3-b]furan-4,9-dione, 2-bromo-       - N-methyl-N-(4-(3-(pyrrolidin-1-yl)propoxy)benzyl)-4-(2,6...       - pararosaniline pamoate       - protein toxin a 23 - mw approx. 6700       - protein toxin c 10 - mw approx. 6700       - riboprine(usan)       - tp38-279       - Tyrothricin       -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: LINC00999

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).