Basic Information:

  VIRBase ID:  

HHID00007941

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          C10orf126:  NR_164114     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	C10orf126
miRBase Accession/Entrez ID	MIMAT0004512	283080
Organism	Homo sapiens	Homo sapiens
Category	miRNA	lncRNA
Alias	-	bA492M23.1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

Resource	Symbol	SNP ID	SNP Position	Ref/Alt	PMID
LincSNP 3.0	C10orf126	rs1691943 chr10:28871907 A/G         20064070 rs1775933 chr10:28871947 A/G         20064070 rs1775929 chr10:28870419 G/T         20064070 rs1691946 chr10:28871528 T/G         20064070 rs12413301 chr10:28868693 A/G         20339536 rs4747634 chr10:28873974 C/G         20339536 rs1495672 chr10:28846676 C/T         20339536 rs10159503 chr10:28867121 C/T         20339536 rs7905314 chr10:28881248 C/T         20502693 rs12246394 chr10:28863874 G/T         20502693 rs4747633 chr10:28867143 A/G         21743057 rs7088136 chr10:28870561 G/A         21743057 rs11007273 chr10:28866903 C/T         22484627 rs2798768 chr10:28868157 A/C         23202124 rs787328 chr10:28850666 A/G         23202124 rs1691944 chr10:28871792 A/G         23202124 rs1775934 chr10:28872083 A/G         23202124 rs1630714 chr10:28869577 C/T         23202124 rs1632622 chr10:28872184 C/T         23202124 rs1691947 chr10:28871376 C/T         23202124 rs1833023 chr10:28876766 G/T         23202124 rs17692695 chr10:28880454 A/G         23297363 rs7918685 chr10:28846997 C/G         23722424

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C10orf126	chr10:29138033(+) A-I      intronic chr10:29145430(+) A-I      intronic chr10:29145435(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	C10orf126	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	C10orf126	3-(Dimethylamino)propiophenone hydrochloride       92844 Nilotinib       644241 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 9-alpha-Hydroxyparthenolide       5477074 8-Hydroxy-3-phenylisocoumarin       5473194 Palbociclib       5330286 Vemurafenib       42611257 1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904 Demethyltylophorinine       261792 Sorafenib       216239 Lapatinib       208908 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967 N,N-Dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine       135564599 Dovitinib       135398510 Crizotinib       11626560 Saracatinib       10302451 ;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: C10orf126

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).