Basic Information:

  VIRBase ID:  

HHID00007939

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          HHLA3:  NR_168350     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	HHLA3
miRBase Accession/Entrez ID	MIMAT0004512	11147
Organism	Homo sapiens	Homo sapiens
Category	miRNA	lncRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HHLA3	chr1:70824793(+) A-I      intronic chr1:70831669(+) A-I      intronic chr1:70831670(+) A-I      intronic chr1:70831671(+) A-I      intronic chr1:70831691(+) A-I      intronic chr1:70829520(+) A-I      intronic chr1:70824825(+) A-I      intronic chr1:70824777(+) A-I      intronic chr1:70829755(+) A-I      intronic chr1:70824784(+) A-I      intronic chr1:70824778(+) A-I      intronic chr1:70830719(+) A-I      intronic chr1:70823988(+) A-I      intronic chr1:70821468(+) A-I      intronic chr1:70828178(+) A-I      intronic chr1:70824902(+) A-I      intronic chr1:70824386(+) A-I      intronic chr1:70824414(+) A-I      intronic chr1:70824399(+) A-I      intronic chr1:70822256(+) A-I      intronic chr1:70823449(+) A-I      intronic chr1:70823842(+) A-I      intronic chr1:70823628(+) A-I      intronic chr1:70824230(+) A-I      intronic chr1:70824139(+) A-I      intronic chr1:70824000(+) A-I      intronic chr1:70821372(+) A-I      intronic chr1:70821538(+) A-I      intronic chr1:70823987(+) A-I      intronic chr1:70828199(+) A-I      intronic chr1:70823934(+) A-I      intronic chr1:70821563(+) A-I      intronic chr1:70822159(+) A-I      intronic chr1:70824734(+) A-I      intronic chr1:70822301(+) A-I      intronic chr1:70823412(+) A-I      intronic chr1:70823403(+) A-I      intronic chr1:70824223(+) A-I      intronic chr1:70821512(+) A-I      intronic chr1:70822252(+) A-I      intronic chr1:70823499(+) A-I      intronic chr1:70823505(+) A-I      intronic chr1:70823781(+) A-I      intronic chr1:70828772(+) A-I      intronic chr1:70828744(+) A-I      intronic chr1:70840253(+) A-I      intronic chr1:70822615(+) A-I      intronic chr1:70828262(+) A-I      intronic chr1:70828668(+) A-I      intronic chr1:70824735(+) A-I      intronic chr1:70823851(+) A-I      intronic chr1:70824352(+) A-I      intronic chr1:70831180(+) A-I      intronic chr1:70822601(+) A-I      intronic chr1:70822265(+) A-I      intronic chr1:70821509(+) A-I      intronic chr1:70824686(+) A-I      intronic chr1:70822522(+) A-I      intronic chr1:70830238(+) A-I      intronic chr1:70847389(+) A-I      intronic chr1:70830239(+) A-I      intronic chr1:70826801(+) A-I      intronic chr1:70829431(+) A-I      intronic chr1:70823658(+) A-I      intronic chr1:70831546(+) A-I      intronic chr1:70823592(+) A-I      intronic chr1:70828232(+) A-I      intronic chr1:70828816(+) A-I      intronic chr1:70822523(+) A-I      intronic chr1:70823629(+) A-I      intronic chr1:70822158(+) A-I      intronic chr1:70831421(+) A-I      intronic chr1:70824819(+) A-I      intronic chr1:70824846(+) A-I      intronic chr1:70826798(+) A-I      intronic chr1:70831717(+) A-I      intronic chr1:70828224(+) A-I      intronic chr1:70831424(+) A-I      intronic chr1:70823447(+) A-I      intronic chr1:70823419(+) A-I      intronic chr1:70824229(+) A-I      intronic chr1:70822254(+) A-I      intronic chr1:70824760(+) A-I      intronic chr1:70823576(+) A-I      intronic chr1:70821415(+) A-I      intronic chr1:70823598(+) A-I      intronic chr1:70821393(+) A-I      intronic chr1:70824426(+) A-I      intronic chr1:70824404(+) A-I      intronic chr1:70824052(+) A-I      intronic chr1:70829756(+) A-I      intronic chr1:70828175(+) A-I      intronic chr1:70821422(+) A-I      intronic chr1:70829930(+) A-I      intronic chr1:70829891(+) A-I      intronic chr1:70829918(+) A-I      intronic chr1:70821580(+) A-I      intronic chr1:70830296(+) A-I      intronic chr1:70821494(+) A-I      intronic chr1:70824244(+) A-I      intronic chr1:70830013(+) A-I      intronic chr1:70831675(+) A-I      intronic chr1:70828238(+) A-I      intronic chr1:70824667(+) A-I      intronic chr1:70828242(+) A-I      intronic chr1:70831737(+) A-I      intronic chr1:70830132(+) A-I      intronic chr1:70821526(+) A-I      intronic chr1:70822590(+) A-I      intronic chr1:70830511(+) A-I      intronic chr1:70821503(+) A-I      intronic chr1:70830972(+) A-I      intronic chr1:70823632(+) A-I      intronic chr1:70821429(+) A-I      intronic chr1:70828760(+) A-I      intronic chr1:70821377(+) A-I      intronic chr1:70823481(+) A-I      intronic chr1:70823482(+) A-I      intronic chr1:70824349(+) A-I      intronic chr1:70824680(+) A-I      intronic chr1:70823577(+) A-I      intronic chr1:70824797(+) A-I      intronic chr1:70824252(+) A-I      intronic chr1:70823864(+) A-I      intronic chr1:70822502(+) A-I      intronic chr1:70824361(+) A-I      intronic chr1:70821602(+) A-I      intronic chr1:70821589(+) A-I      intronic chr1:70828709(+) A-I      intronic chr1:70828682(+) A-I      intronic chr1:70829760(+) A-I      intronic chr1:70824071(+) A-I      intronic chr1:70823908(+) A-I      intronic chr1:70821590(+) A-I      intronic chr1:70821458(+) A-I      intronic chr1:70824746(+) A-I      intronic chr1:70845544(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HHLA3	chr1:70830013(+) A-I intron -    22327324 chr1:70830238(+) A-I intron -    22327324 chr1:70830239(+) A-I intron -    22327324 chr1:70822158(+) A-I intron -    21960545 chr1:70830013(+) A-G intron -    22484847 chr1:70830238(+) A-G intron -    22484847 chr1:70830239(+) A-G intron -    22484847 chr1:70821377(+) A-G intron -    22484847 chr1:70821422(+) A-G intron -    22484847 chr1:70821503(+) A-G intron -    22484847 chr1:70821512(+) A-G intron -    22484847 chr1:70823403(+) A-G intron -    22484847 chr1:70823412(+) A-G intron -    22484847 chr1:70823447(+) A-G intron -    22484847 chr1:70823482(+) A-G intron -    22484847 chr1:70823499(+) A-G intron -    22484847 chr1:70823576(+) A-G intron -    22484847 chr1:70823577(+) A-G intron -    22484847 chr1:70823592(+) A-G intron -    22484847 chr1:70823908(+) A-G intron -    22484847 chr1:70824223(+) A-G intron -    22484847 chr1:70824229(+) A-G intron -    22484847 chr1:70824846(+) A-G intron -    22484847 chr1:70828232(+) A-G intron -    22484847 chr1:70828242(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HHLA3	chr1:70820573-70820574(+) m6A 5'UTR//exon       24284625//24981863 chr1:70820615-70820616(+) m6A 5'UTR//exon       24284625//24981863 chr1:70820654-70820655(+) m6A CDS//exon       24284625//24981863 chr1:70820867-70820868(+) m6A CDS//exon//intron       24981863 chr1:70833496-70833497(+) m6A 3'UTR//intron       24284625//24981863 chr1:70833565-70833566(+) m6A 3'UTR//intron       24284625//24981863 chr1:70833655-70833656(+) m6A 3'UTR//intron       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	HHLA3	Chromatin K562 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	HHLA3	6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222 Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773 Tivozanib       9911830 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-YL)-3-methyl-1H-pyrazol-5-YL]-6-ethylbenzene-1,3-diol       984170 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846 Tiotixene       941651 Trimelamol       92368 Pentamidine isethionate       8813 Benzethonium chloride       8478 Phenformin       8249 Bexarotene       82146 3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride       75442 Nonactin       72519 Piperidinium pentamethylenedithiocarbamate       72508 Berberine iodide       72350 Tolonium chloride       7083 Panobinostat       6918837 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454 Daporinad       6914657 3-Hydroxy-3'-nitro-2-naphthanilide       67277 2,2,2-Trifluoro-N-(7-nitro-1-oxido-1,2,4-benzotriazin-1-ium-3-yl)acetamide       6711497 Astrafloksin       6540442 AICA ribonucleotide       65110 Ispinesib mesylate       6450816 Axitinib       6450551 Pelitinib       6445562 Concanamycin a       6438151 4-(N-Hydroxyacetamido)stilbene       6433723 Primaquine phosphate       6135 Irinotecan       60838 Gemcitabine       60750 Mitomycin       5746 3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804 Methyl N-[6-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate;hydrochloride       57399798 Dimethyloxalylglycine       560326 Ethyl red       54832 Phyllanthastatin 1       5477587 Lfm-a13       54676905 Mito-tempol       54613387 Olivomycin Transformation       54610760 Austrocortirubin       5459130 Zimeldine       5365247 Rubremetinium chloride       5351504 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664 Palbociclib       5330286 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361 Vorinostat       5311 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396 Bis(2-hydroxy-1-naphthyl) disulfide       521106 Alsterpaullone       5005498 Venetoclax       49846579 Pentamidine       4735 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713 2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432 N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454 N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912 Okadaic acid       446512 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660 Dabrafenib       44462760 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine       44397453 Iproplatin       44214 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid       44137675 1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one       387973 3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide       383342 2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol       3796 N, O-Diethoxyacetyl-3-demethyldeactylthiocolchicin       379556 2-(3,3-Butadiene       377927 2-Amino-5,8-dihydroxy-1,4-naphthoquinone       377209 N-Hydroxy-N-methylpropanethioamide       371713 3-Nitro-5-formylisoxazole       362479 3,4-Dihydroxynaphthalene-2-carboxylic acid       356138 5-Fluorouracil       3385 N6-Benzyladenosine-5'-phosphate       318601 N,N'-Bis(3-nitrophenyl)isophthalamide       306548 (3-Phenoxypropyl)triphenylphosphonium bromide       3048782 Phenanthrene-9,10-diimine       2981 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557 3-Amino-N-(4-butoxyphenyl)-1H-indazole-1-carboxamide       25199443 Navitoclax       24978538 10-(6'-Ubiquinolyl)decyltriphenylphosphonium       24783759 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860 6-(Hexynyl)-2(2H)-pyranone       24203137 (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide       24200489 1-Dodecyl-4-nonylpyridinium chloride       24180869 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719 1-Decarboxy-3-oxo-ceanothic acid       23243541 6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride       21701565 Nutlin-3       216345 Lenalidomide       216326 Kinetin riboside       20345 8-Hydroxyquinoline       1923 Erlotinib       176870 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388 Mercury, (acetyloxy)(pentamethylphenyl)-       16683786 N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967 Astrazon Orange R       135747272 (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062 Eriochrome Blue Black B       135465071 Dovitinib       135398510 Akt inhibitor VIII       135398501 Methotrexate       126941 Lestaurtinib       126565 Berberine chloride       12456 Mikamycin, B grade       11979458 Dactolisib       11977753 (Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261 BAY 61-3606 dihydrochloride       11784504 Trametinib       11707110 4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725 Crizotinib       11626560 5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598 Linifanib       11485656 Nvp-aew541       11476171 Bafetinib       11387605 Pararosaniline hydrochloride       11292 Amuvatinib       11282283 (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667 Setoglaucine       107404 [(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721 Dequalinium chloride       10649 Pha-665752       10461815 VX-702       10341154 Cepharanthine       10206 Selumetinib       10127622 Masitinib       10074640 PDK1 inhibitor AR-12       10027278 25-Dihydrosaframycin A       100180 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion       - 1,4-benzenediamine (9ci), n-butyl-n'-phenyl-       - (24s)-24-o-acetyl,-7,8-didehydroshengmanol xyloside       - 2h-tetrazolium, 3-(2-biphenylyl)-2,5-diphenyl- chloride       - 4-morpholinecarbodithioic acid, antimony complex       - 4-thiomorpholinecarbodithioic acid, antimony complex       - 5,6-ethylenediquino[3,2-b       - ;9-benzyl-7-benzyloxy-2-benzyl-1-methyl-9H-carbolinium b...       - benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       - [co(me2dtc)2(dee)]clo4       - ;(E)-3-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)met...       - ;(E)-3-(4-ethynylphenyl)-2-(2-(naphthalen-2-yl)vinyl)pyr...       - gamitrinib-g4       - gramicidin       - g-tpp       - indoline, 5-chloro-1,3,3-trimethyl-2-methylene- (8ci)       - JW-7-24-1       - KIN001-236       - KIN001-244       - KIN001-260       - methylbenzethonium chloride (usan)       - MPS-1-IN-1       - naphthalen-1,4-dione, 3-butanoylamino-2-chloro-1,4-dihydro-       - Nutlin-3a (-)       - pararosaniline pamoate       - phosphonium, triphenylpropenyl-, bromide, (e)- (8ci)       - piperidinium, 1,1-didodecyl-3-methyl-, bromide       - protein toxin c 10 - mw approx. 6700       - QL-XI-92       - rhodium dimer       - TL-1-85       - TL-2-105       - tp4ek       - Tyrothricin       - XMD14-99       - XMD15-27       -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: HHLA3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).