Basic Information:

  VIRBase ID:  

HHID00007903

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-2-5p:  MIMAT0004492          GRPEL2:  NM_152407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-2-5p	GRPEL2
miRBase Accession/Entrez ID	MIMAT0004492	134266
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Mt-GrpE#2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-2-5p	rs193073651 chrX:134169728    G/A rs749008511 chrX:134169737    A/C rs755951722 chrX:134169731    A/G rs779795647 chrX:134169732    T/C rs747654746 chrX:134169746    A/G rs754566533 chrX:134169743    A/G rs778397250 chrX:134169744    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GRPEL2	chr5:148728733(+) A-I      intronic chr5:148726430(+) A-I      intronic chr5:148728719(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GRPEL2	chr5:148725100-148725101(+) m6A 5'UTR       24284625//24981863 chr5:148725214-148725215(+) m6A exon//intron       24284625//24981863 chr5:148725347-148725348(+) m6A exon//intron       - chr5:148727871-148727872(+) m6A CDS//exon       - chr5:148727884-148727885(+) m6A CDS//exon       - chr5:148727899-148727900(+) m6A CDS//exon       - chr5:148727960-148727961(+) m6A CDS//exon       27773535 chr5:148729250-148729251(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729264-148729265(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729412-148729413(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:148730501-148730502(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr5:148730533-148730534(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730570-148730571(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730661-148730662(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730703-148730704(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730763-148730764(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730778-148730779(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730838-148730839(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730859-148730860(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730909-148730910(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr5:148733905-148733906(+) m6A 3'UTR//exon       27773535 chr5:148734025-148734026(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734052-148734053(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734081-148734082(+) m6A 3'UTR//exon       27773535 chr5:148734111-148734112(+) m6A 3'UTR//exon       27773535 chr5:148734125-148734126(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-2-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	GRPEL2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-2-5p
Interactor2: GRPEL2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).