Detail Information

Basic Information:


  VIRBase ID:  

HHID00007867

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-2-5p:           UBE2J1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19b-2-5p UBE2J1
miRBase
Accession/Entrez ID		 MIMAT0004492 51465
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-76//HSPC153//HSPC205//HSU93243//NCUBE-1//NCUBE1//UBC6//UBC6E//Ubc6p

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19b-2-5p
rs193073651 chrX:134169728    G/A
rs749008511 chrX:134169737    A/C
rs755951722 chrX:134169731    A/G
rs779795647 chrX:134169732    T/C
rs747654746 chrX:134169746    A/G
rs754566533 chrX:134169743    A/G
rs778397250 chrX:134169744    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UBE2J1
chr6:90040447(-) A-I      intronic
chr6:90060980(-) A-I      intronic
chr6:90060965(-) A-I      intronic
chr6:90040393(-) A-I      intronic
chr6:90060978(-) A-I      intronic
chr6:90040407(-) A-I      intronic
chr6:90055277(-) A-I      intronic
chr6:90049691(-) A-I      intronic
chr6:90048656(-) A-I      intronic
chr6:90055868(-) A-I      intronic
chr6:90048635(-) A-I      intronic
chr6:90055269(-) A-I      intronic
chr6:90055199(-) A-I      intronic
chr6:90055149(-) A-I      intronic
chr6:90040501(-) A-I      intronic
chr6:90040454(-) A-I      intronic
chr6:90040453(-) A-I      intronic
chr6:90040403(-) A-I      intronic
chr6:90040121(-) A-I      intronic
chr6:90040120(-) A-I      intronic
chr6:90055124(-) A-I      intronic
chr6:90051443(-) A-I      intronic
chr6:90051402(-) A-I      intronic
chr6:90043819(-) A-I      intronic
chr6:90055852(-) A-I      intronic
chr6:90049696(-) A-I      intronic
chr6:90043861(-) A-I      intronic
chr6:90055786(-) A-I      intronic
chr6:90040330(-) A-I      intronic
chr6:90040463(-) A-I      intronic
chr6:90044003(-) A-I      intronic
chr6:90055282(-) A-I      intronic
chr6:90051221(-) A-I      intronic
chr6:90051315(-) A-I      intronic
chr6:90044363(-) A-I      intronic
chr6:90046043(-) A-I      intronic
chr6:90049556(-) A-I      intronic
chr6:90055785(-) A-I      intronic
chr6:90040292(-) A-I      intronic
chr6:90040295(-) A-I      intronic
chr6:90040341(-) A-I      intronic
chr6:90040507(-) A-I      intronic
chr6:90040278(-) A-I      intronic
chr6:90060936(-) A-I      intronic
chr6:90046683(-) A-I      intronic
chr6:90055238(-) A-I      intronic
chr6:90055738(-) A-I      intronic
chr6:90055477(-) A-I      intronic
chr6:90046687(-) A-I      intronic
chr6:90040347(-) A-I      intronic
chr6:90055361(-) A-I      intronic
chr6:90040399(-) A-I      intronic
chr6:90044366(-) A-I      intronic
chr6:90040415(-) A-I      intronic
chr6:90049033(-) A-I      intronic
chr6:90055787(-) A-I      intronic
chr6:90049729(-) A-I      intronic
chr6:90055790(-) A-I      intronic
chr6:90058837(-) A-I      intronic
chr6:90049694(-) A-I      intronic
chr6:90044368(-) A-I      intronic
chr6:90055221(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UBE2J1
chr6:90040341(-) A-I intron -    21960545   //22327324
chr6:90040345(-) A-I intron -    21960545
chr6:90051299(-) A-I intron -    21960545
chr6:90040292(-) A-G intron -    22484847
chr6:90040341(-) A-G intron -    22484847
chr6:90040343(-) A-G intron -    22484847
chr6:90040415(-) A-G intron -    22484847
chr6:90049066(-) A-G intron -    22484847
chr6:90049556(-) A-G intron -    22484847
chr6:90049694(-) A-G intron -    22484847
chr6:90049696(-) A-G intron -    22484847
chr6:90049729(-) A-G intron -    22484847
chr6:90051444(-) A-G intron -    22484847
chr6:90051445(-) T-G intron -    22484847
chr6:90053153(-) G-T intron -    22484847
chr6:90055221(-) A-G intron -    22484847
chr6:90055238(-) A-G intron -    22484847
chr6:90055282(-) A-G intron -    22484847
chr6:90055477(-) A-G intron -    22484847
chr6:90055726(-) A-G intron -    22484847
chr6:90055792(-) A-G intron -    22484847
chr6:90055869(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UBE2J1
chr6:90036616-90036617(-) m6A 3'UTR       27773535
chr6:90036647-90036648(-) m6A 3'UTR       27773535
chr6:90036665-90036666(-) m6A 3'UTR       27773535
chr6:90036695-90036696(-) m6A 3'UTR       27773535
chr6:90038127-90038128(-) m6A 3'UTR       27773535
chr6:90039352-90039353(-) m6A 3'UTR       24981863
chr6:90039518-90039519(-) m6A CDS       24284625//24981863//27773535
chr6:90039670-90039671(-) m6A CDS       27773535
chr6:90042877-90042878(-) m6A CDS       27773535
chr6:90042883-90042884(-) m6A CDS       27773535
chr6:90042899-90042900(-) m6A CDS       27773535
chr6:90045044-90045045(-) m6A CDS       27773535
chr6:90052066-90052067(-) m6A CDS       -
chr6:90052130-90052131(-) m6A CDS       27773535
chr6:90062281-90062282(-) m6A CDS       27371828//27773536
chr6:90062358-90062359(-) m6A 5'UTR       27371828//27773536
chr6:90062417-90062418(-) m6A 5'UTR       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19b-2-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
UBE2J1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19b-2-5p
Interactor2: UBE2J1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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