Detail Information

Basic Information:


  VIRBase ID:  

HHID00007798

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19b-1-5p NPIPB7
miRBase
Accession/Entrez ID		 MIMAT0004491 440350
Organism Homo sapiens Homo sapiens
Category miRNA pseudo
Alias - A-575C2.4//A-761H5.5//NPIPL1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19b-1-5p
rs1330845252 chr13:91351221    G/A
rs771220050 chr13:91351229    C/T
rs1259633726 chr13:91351212    T/G
rs1279688822 chr13:91351213    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NPIPB7
chr16:28478161-28478162(-) m6A CDS       24284625//24981863
chr16:28478186-28478187(-) m6A CDS       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19b-1-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
NPIPB7
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-19b-1-5p
Gemcitabine 60750 Drug interaction    RC00006805
5-Fluorouracil 3385 Drug interaction    RC00006803
Doxorubicin 31703 Drug interaction    RC00006804
Verapamil 2520 Drug interaction    RC00006802
Resource Symbol Drug Name PubChem ID
RNAactDrug NPIPB7
Panobinostat       6918837
l-685,458       5479543
Palbociclib       5330286
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19b-1-5p
Interactor2: NPIPB7

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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