Basic Information:

  VIRBase ID:  

HHID00007784

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          NPIPB5:  NM_001135865     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	NPIPB5
miRBase Accession/Entrez ID	MIMAT0004491	100132247
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NPIPB5	chr16:22533383(+) A-I      intronic chr16:22533404(+) A-I      intronic chr16:22533399(+) A-I      intronic chr16:22534501(+) A-I      intronic chr16:22534415(+) A-I      intronic chr16:22533415(+) A-I      intronic chr16:22533423(+) A-I      intronic chr16:22533459(+) A-I      intronic chr16:22533807(+) A-I      intronic chr16:22532227(+) A-I      intronic chr16:22525575(+) A-I      intronic chr16:22525739(+) A-I      intronic chr16:22533824(+) A-I      intronic chr16:22533848(+) A-I      intronic chr16:22533850(+) A-I      intronic chr16:22533858(+) A-I      intronic chr16:22533878(+) A-I      intronic chr16:22534033(+) A-I      intronic chr16:22534375(+) A-I      intronic chr16:22534381(+) A-I      intronic chr16:22526243(+) A-I      intronic chr16:22534386(+) A-I      intronic chr16:22534369(+) A-I      intronic chr16:22526311(+) A-I      intronic chr16:22526312(+) A-I      intronic chr16:22526316(+) A-I      intronic chr16:22526329(+) A-I      intronic chr16:22526340(+) A-I      intronic chr16:22526385(+) A-I      intronic chr16:22526391(+) A-I      intronic chr16:22526394(+) A-I      intronic chr16:22526396(+) A-I      intronic chr16:22526408(+) A-I      intronic chr16:22526413(+) A-I      intronic chr16:22531906(+) A-I      intronic chr16:22531907(+) A-I      intronic chr16:22532141(+) A-I      intronic chr16:22532193(+) A-I      intronic chr16:22532210(+) A-I      intronic chr16:22532213(+) A-I      intronic chr16:22532263(+) A-I      intronic chr16:22532283(+) A-I      intronic chr16:22532549(+) A-I      intronic chr16:22532601(+) A-I      intronic chr16:22532672(+) A-I      intronic chr16:22532673(+) A-I      intronic chr16:22533298(+) A-I      intronic chr16:22533317(+) A-I      intronic chr16:22533318(+) A-I      intronic chr16:22533402(+) A-I      intronic chr16:22534525(+) A-I      intronic chr16:22525566(+) A-I      intronic chr16:22525668(+) A-I      intronic chr16:22525591(+) A-I      intronic chr16:22525669(+) A-I      intronic chr16:22525670(+) A-I      intronic chr16:22525671(+) A-I      intronic chr16:22525749(+) A-I      intronic chr16:22525732(+) A-I      intronic chr16:22525631(+) A-I      intronic chr16:22525665(+) A-I      intronic chr16:22525672(+) A-I      intronic chr16:22525755(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NPIPB5	chr16:22539280-22539281(+) m6A 3'UTR//CDS//exon       24981863 chr16:22539291-22539292(+) m6A 3'UTR//CDS//exon       24981863 chr16:22539329-22539330(+) m6A exon//intron       24981863 chr16:22539350-22539351(+) m6A exon//intron       24981863 chr16:22545015-22545016(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr16:22545025-22545026(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr16:22545096-22545097(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr16:22545153-22545154(+) m6A 3'UTR//CDS//exon       24284625 chr16:22545210-22545211(+) m6A 3'UTR//CDS//exon       24284625 chr16:22545267-22545268(+) m6A 3'UTR//CDS//exon       24284625 chr16:22545840-22545841(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr16:22545897-22545898(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr16:22547666-22547667(+) m6A 3'UTR//CDS//exon       24981863 chr16:22547681-22547682(+) m6A 3'UTR//CDS//exon       24981863 chr16:22547746-22547747(+) m6A 3'UTR//exon       24981863 chr16:22547756-22547757(+) m6A 3'UTR//exon       24981863 chr16:22547777-22547778(+) m6A 3'UTR//exon       24981863 chr16:22547782-22547783(+) m6A 3'UTR//exon       24981863 chr16:22547787-22547788(+) m6A 3'UTR//exon       24981863 chr16:22547802-22547803(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	NPIPB5	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: NPIPB5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).