Basic Information:

  VIRBase ID:  

HHID00007773

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          LHX8:  NM_001256114     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	LHX8
miRBase Accession/Entrez ID	MIMAT0004491	431707
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LHX7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LHX8	chr1:75595944-75595945(+) m6A 5'UTR       24981863 chr1:75595972-75595973(+) m6A 5'UTR       24981863 chr1:75595987-75595988(+) m6A 5'UTR       24981863 chr1:75596007-75596008(+) m6A 5'UTR       24981863 chr1:75596022-75596023(+) m6A 5'UTR       24981863 chr1:75596051-75596052(+) m6A 5'UTR       24981863 chr1:75596061-75596062(+) m6A 5'UTR       24981863 chr1:75596087-75596088(+) m6A 5'UTR       24981863 chr1:75596196-75596197(+) m6A 5'UTR       24981863 chr1:75596226-75596227(+) m6A 5'UTR       24981863 chr1:75596312-75596313(+) m6A 5'UTR       24981863 chr1:75596346-75596347(+) m6A 5'UTR       24981863 chr1:75622612-75622613(+) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	LHX8	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: LHX8

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).