Basic Information:

  VIRBase ID:  

HHID00007769

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          ZNF790:  NM_001242802     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	ZNF790
miRBase Accession/Entrez ID	MIMAT0004491	388536
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF790	chr19:37319592(-) A-I      intronic chr19:37319503(-) A-I      intronic chr19:37319507(-) A-I      intronic chr19:37311735(-) A-I      intronic chr19:37319452(-) A-I      intronic chr19:37319653(-) A-I      intronic chr19:37319455(-) A-I      intronic chr19:37311690(-) A-I      intronic chr19:37319457(-) A-I      intronic chr19:37311676(-) A-I      intronic chr19:37319471(-) A-I      intronic chr19:37322384(-) A-I      intronic chr19:37321965(-) A-I      intronic chr19:37320666(-) A-I      intronic chr19:37320672(-) A-I      intronic chr19:37320673(-) A-I      intronic chr19:37321797(-) A-I      intronic chr19:37321798(-) A-I      intronic chr19:37320607(-) A-I      intronic chr19:37320624(-) A-I      intronic chr19:37321852(-) A-I      intronic chr19:37317244(-) A-I      intronic chr19:37321868(-) A-I      intronic chr19:37321877(-) A-I      intronic chr19:37308892(-) A-I      3'UTR chr19:37308801(-) A-I      3'UTR chr19:37308857(-) A-I      3'UTR chr19:37308797(-) A-I      3'UTR chr19:37308980(-) A-I      3'UTR chr19:37308952(-) A-I      3'UTR chr19:37308903(-) A-I      3'UTR chr19:37308893(-) A-I      3'UTR chr19:37308918(-) A-I      3'UTR chr19:37308792(-) A-I      3'UTR chr19:37308938(-) A-I      3'UTR chr19:37308876(-) A-I      3'UTR chr19:37308760(-) A-I      3'UTR chr19:37308889(-) A-I      3'UTR chr19:37308873(-) A-I      3'UTR chr19:37320755(-) A-I      intronic chr19:37324249(-) A-I      intronic chr19:37319534(-) A-I      intronic chr19:37319606(-) A-I      intronic chr19:37311682(-) A-I      intronic chr19:37319660(-) A-I      intronic chr19:37320634(-) A-I      intronic chr19:37319594(-) A-I      intronic chr19:37324227(-) A-I      intronic chr19:37320504(-) A-I      intronic chr19:37324953(-) A-I      intronic chr19:37308992(-) A-I      3'UTR chr19:37308863(-) A-I      3'UTR chr19:37324973(-) A-I      intronic chr19:37319540(-) A-I      intronic chr19:37320598(-) A-I      intronic chr19:37322372(-) A-I      intronic chr19:37322376(-) A-I      intronic chr19:37308904(-) A-I      3'UTR chr19:37327666(-) A-I      intronic chr19:37319518(-) A-I      intronic chr19:37320719(-) A-I      intronic chr19:37311571(-) A-I      intronic chr19:37320608(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF790	chr19:37309557(-) A-I exon CDS    15342557 chr19:37310344(-) A-I exon CDS    15342557 chr19:37330336(-) A-I intron -    22327324 chr19:37330441(-) A-I intron -    22327324 chr19:37330447(-) A-I intron -    22327324 chr19:37330837(-) A-I intron -    22327324 chr19:37330843(-) A-I intron -    22327324 chr19:37332911(-) A-I intron -    22327324 chr19:37336983(-) A-I intron -    22327324 chr19:37339944(-) A-I intron -    22327324 chr19:37319652(-) T-C intron -    22484847 chr19:37319663(-) T-C intron -    22484847 chr19:37325047(-) T-C intron -    22484847 chr19:37325056(-) T-C intron -    22484847 chr19:37325060(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF790	chr19:37309257-37309258(-) m6A 3'UTR       27773535 chr19:37309437-37309438(-) m6A CDS       27773535//22608085 chr19:37309458-37309459(-) m6A CDS       27773535//22608085 chr19:37309471-37309472(-) m6A CDS       27773535//22608085 chr19:37309508-37309509(-) m6A CDS       27773535//22608085 chr19:37309565-37309566(-) m6A CDS       27773535//22608085 chr19:37309649-37309650(-) m6A CDS       27773535//22608085 chr19:37309769-37309770(-) m6A CDS       27773535//22608085 chr19:37309789-37309790(-) m6A CDS       27773535//22608085 chr19:37309815-37309816(-) m6A CDS       27773535//22608085 chr19:37309873-37309874(-) m6A CDS       27773535//22608085 chr19:37309957-37309958(-) m6A CDS       22608085 chr19:37310489-37310490(-) m6A CDS       27773535//22608085 chr19:37310572-37310573(-) m6A CDS       27773535//22608085 chr19:37310593-37310594(-) m6A CDS       27773535//22608085 chr19:37310723-37310724(-) m6A CDS       24981863//27773535//22608085 chr19:37310745-37310746(-) m6A CDS       24981863//27773535//22608085 chr19:37310759-37310760(-) m6A CDS       24981863//27773535//22608085 chr19:37310860-37310861(-) m6A CDS       24981863//27773535//22608085 chr19:37310919-37310920(-) m6A CDS       27773535//22608085 chr19:37314591-37314592(-) m6A CDS       24209618 chr19:37314626-37314627(-) m6A CDS       24209618 chr19:37314633-37314634(-) m6A CDS       24209618 chr19:37316537-37316538(-) m6A 5'UTR       27773535 chr19:37316545-37316546(-) m6A 5'UTR       27773535 chr19:37328635-37328636(-) m6A 5'UTR//intron       - chr19:37328723-37328724(-) m6A 5'UTR//intron       27773535 chr19:37328734-37328735(-) m6A 5'UTR//intron       27773535 chr19:37328860-37328861(-) m6A 5'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ZNF790	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: ZNF790

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).