Basic Information:

  VIRBase ID:  

HHID00007768

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          SLC22A10:  NR_134874     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	SLC22A10
miRBase Accession/Entrez ID	MIMAT0004491	387775
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hOAT5//OAT5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC22A10	chr11:62912938(+) A-I      intronic chr11:62912931(+) A-I      intronic chr11:62912984(+) A-I      intronic chr11:62912985(+) A-I      intronic chr11:62912962(+) A-I      intronic chr11:62912957(+) A-I      intronic chr11:62912942(+) A-I      intronic chr11:63077340(+) A-I      intronic chr11:62912878(+) A-I      intronic chr11:63067622(+) A-I      intronic chr11:62912919(+) A-I      intronic chr11:63067636(+) A-I      intronic chr11:62912918(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC22A10	chr11:63065138-63065139(+) m6A CDS//exon//intron       27773535 chr11:63065146-63065147(+) m6A CDS//exon//intron       27773535 chr11:63066433-63066434(+) m6A CDS//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	SLC22A10	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: SLC22A10

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).