Basic Information:

  VIRBase ID:  

HHID00007764

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          ANKRD36:  NM_001354587     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	ANKRD36
miRBase Accession/Entrez ID	MIMAT0004491	375248
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	UNQ2430

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ANKRD36	chr2:97824104(+) A-I      intronic chr2:97918331(+) A-I      intronic chr2:97918330(+) A-I      intronic chr2:97828793(+) A-I      intronic chr2:97824240(+) A-I      intronic chr2:97824106(+) A-I      intronic chr2:97829595(+) A-I      intronic chr2:97917915(+) A-I      3'UTR chr2:97829470(+) A-I      3'UTR chr2:97829488(+) A-I      3'UTR chr2:97829494(+) A-I      3'UTR chr2:97922015(+) A-I      intronic chr2:97921990(+) A-I      intronic chr2:97828817(+) A-I      intronic chr2:97918414(+) A-I      intronic chr2:97918464(+) A-I      intronic chr2:97921908(+) A-I      intronic chr2:97921983(+) A-I      intronic chr2:97921917(+) A-I      intronic chr2:97921897(+) A-I      intronic chr2:97921916(+) A-I      intronic chr2:97921902(+) A-I      intronic chr2:97921915(+) A-I      intronic chr2:97829484(+) A-I      3'UTR chr2:97829356(+) A-I      3'UTR chr2:97829352(+) A-I      3'UTR chr2:97829551(+) A-I      3'UTR chr2:97829417(+) A-I      3'UTR chr2:97829586(+) A-I      3'UTR chr2:97829511(+) A-I      3'UTR chr2:97829442(+) A-I      3'UTR chr2:97917932(+) A-I      3'UTR chr2:97917790(+) A-I      3'UTR chr2:97917823(+) A-I      3'UTR chr2:97917879(+) A-I      3'UTR chr2:97829574(+) A-I      3'UTR chr2:97828857(+) A-I      intronic chr2:97824065(+) A-I      intronic chr2:97828883(+) A-I      intronic chr2:97918465(+) A-I      intronic chr2:97921974(+) A-I      intronic chr2:97828861(+) A-I      intronic chr2:97828750(+) A-I      intronic chr2:97828749(+) A-I      intronic chr2:97828847(+) A-I      intronic chr2:97823994(+) A-I      intronic chr2:97828816(+) A-I      intronic chr2:97921973(+) A-I      intronic chr2:97828992(+) A-I      Syn:Gln->Gln

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ANKRD36	chr2:97917790(+) A-I intron -    15342557   //15258596 chr2:97917823(+) A-I intron -    15342557   //15258596 chr2:97917879(+) A-I intron -    15342557   //15258596 chr2:97917932(+) A-I intron -    15342557   //15258596 chr2:97918125(+) A-I intron -    15342557 chr2:97921897(+) A-I intron -    22028664 chr2:97921902(+) A-I intron -    22028664 chr2:97921908(+) A-I intron -    22028664 chr2:97921915(+) A-I intron -    22028664 chr2:97921916(+) A-I intron -    22028664 chr2:97921917(+) A-I intron -    22028664 chr2:97921974(+) A-I intron -    22028664 chr2:97921983(+) A-I intron -    22028664 chr2:97921990(+) A-I intron -    22028664 chr2:97922015(+) A-I intron -    22028664 chr2:97828749(+) A-G intron -    22484847 chr2:97828750(+) A-G intron -    22484847 chr2:97828816(+) A-G intron -    22484847 chr2:97828817(+) A-G intron -    22484847 chr2:97828847(+) A-G intron -    22484847 chr2:97828857(+) A-G intron -    22484847 chr2:97828861(+) A-G intron -    22484847 chr2:97828979(+) A-G intron -    22484847 chr2:97829352(+) A-G intron -    22484847 chr2:97829439(+) A-G intron -    22484847 chr2:97829442(+) A-G intron -    22484847 chr2:97829452(+) A-G intron -    22484847 chr2:97829454(+) A-G intron -    22484847 chr2:97829484(+) A-G intron -    22484847 chr2:97829519(+) A-G intron -    22484847 chr2:97829551(+) A-G intron -    22484847 chr2:97918388(+) A-G intron -    22484847 chr2:97918410(+) A-G intron -    22484847 chr2:97918464(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ANKRD36	chr2:97808555-97808556(+) m6A CDS//intron       24981863 chr2:97808568-97808569(+) m6A CDS//intron       24981863 chr2:97810267-97810268(+) m6A CDS//intron       24981863 chr2:97853084-97853085(+) m6A CDS//intron       - chr2:97853134-97853135(+) m6A CDS//intron       - chr2:97855023-97855024(+) m6A CDS//intron       - chr2:97856727-97856728(+) m6A CDS//intron       - chr2:97856876-97856877(+) m6A CDS//intron       - chr2:97856914-97856915(+) m6A CDS//intron       - chr2:97858607-97858608(+) m6A CDS//intron       - chr2:97879334-97879335(+) m6A CDS//exon       24981863 chr2:97879347-97879348(+) m6A CDS//exon       24981863 chr2:97881050-97881051(+) m6A CDS//exon       24981863 chr2:97881217-97881218(+) m6A CDS//exon       - chr2:97881230-97881231(+) m6A CDS//exon       - chr2:97907201-97907202(+) m6A CDS//exon       24981863//22608085 chr2:97909699-97909700(+) m6A CDS//exon       - chr2:97909708-97909709(+) m6A CDS//exon       - chr2:97911082-97911083(+) m6A CDS//exon       24981863 chr2:97911114-97911115(+) m6A CDS//exon       24981863//22608085 chr2:97911140-97911141(+) m6A CDS//exon       24284625//24981863//22608085 chr2:97911159-97911160(+) m6A CDS//exon       24284625//24981863//22608085 chr2:97911189-97911190(+) m6A CDS//exon       24284625//24981863//22608085 chr2:97911196-97911197(+) m6A CDS//exon       24284625//24981863//22608085 chr2:97911222-97911223(+) m6A CDS//exon       24284625//24981863//22608085 chr2:97911272-97911273(+) m6A CDS//exon       24284625//24981863//22608085 chr2:97911728-97911729(+) m6A CDS//exon       24981863 chr2:97911750-97911751(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ANKRD36	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|HeLa-S3 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: ANKRD36

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).