Basic Information:

  VIRBase ID:  

HHID00007763

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          HSD11B1L:  NM_198705     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	HSD11B1L
miRBase Accession/Entrez ID	MIMAT0004491	374875
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	11-beta-HSD3//11-DH3//HSD1L//HSD3//SCDR10//SCDR10B//SDR26C2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSD11B1L	chr19:5683741(+) A-I      intronic chr19:5683740(+) A-I      intronic chr19:5685830(+) A-I      intronic chr19:5684208(+) A-I      intronic chr19:5684207(+) A-I      intronic chr19:5683680(+) A-I      intronic chr19:5683629(+) A-I      intronic chr19:5683040(+) A-I      intronic chr19:5682852(+) A-I      intronic chr19:5683083(+) A-I      intronic chr19:5683854(+) A-I      intronic chr19:5683163(+) A-I      intronic chr19:5683747(+) A-I      intronic chr19:5683683(+) A-I      intronic chr19:5682973(+) A-I      intronic chr19:5682930(+) A-I      intronic chr19:5683641(+) A-I      intronic chr19:5683648(+) A-I      intronic chr19:5683756(+) A-I      intronic chr19:5683100(+) A-I      intronic chr19:5682984(+) A-I      intronic chr19:5683067(+) A-I      intronic chr19:5683012(+) A-I      intronic chr19:5684166(+) A-I      intronic chr19:5682971(+) A-I      intronic chr19:5683703(+) A-I      intronic chr19:5684210(+) A-I      intronic chr19:5683209(+) A-I      intronic chr19:5683732(+) A-I      intronic chr19:5683887(+) A-I      intronic chr19:5685670(+) A-I      intronic chr19:5683053(+) A-I      intronic chr19:5682972(+) A-I      intronic chr19:5683128(+) A-I      intronic chr19:5685794(+) A-I      intronic chr19:5682880(+) A-I      intronic chr19:5683701(+) A-I      intronic chr19:5683080(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HSD11B1L	chr19:5683701(+) A-I intron -    21960545 chr19:5683703(+) A-I intron -    21960545 chr19:5683721(+) A-I intron -    21960545 chr19:5684080(+) A-I intron -    21960545 chr19:5684080(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSD11B1L	chr19:5681175-5681176(+) m6A 5'UTR//exon       25456834 chr19:5681204-5681205(+) m6A 5'UTR//exon       25456834 chr19:5681238-5681239(+) m6A 5'UTR//exon       25456834 chr19:5681254-5681255(+) m6A 5'UTR//exon       25456834 chr19:5681266-5681267(+) m6A 5'UTR//exon       25456834 chr19:5688023-5688024(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22608085 chr19:5688035-5688036(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085 chr19:5688079-5688080(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085 chr19:5688092-5688093(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:5688118-5688119(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:5688172-5688173(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085 chr19:5688239-5688240(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr19:5688282-5688283(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr19:5688353-5688354(+) m6A 3'UTR//exon       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	HSD11B1L	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: HSD11B1L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).