Basic Information:

  VIRBase ID:  

HHID00007761

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          ECT2L:  NM_001077706     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	ECT2L
miRBase Accession/Entrez ID	MIMAT0004491	345930
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARHGEF32//C6orf91//dJ509I19.2//dJ509I19.3//dJ509I19.5//FBXO49//LFDH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ECT2L	chr6:139129895(+) A-I      intronic chr6:139181045(+) A-I      intronic chr6:139181052(+) A-I      intronic chr6:139181056(+) A-I      intronic chr6:139181055(+) A-I      intronic chr6:139129958(+) A-I      intronic chr6:139130435(+) A-I      intronic chr6:139130437(+) A-I      intronic chr6:139130520(+) A-I      intronic chr6:139160766(+) A-I      intronic chr6:139163334(+) A-I      intronic chr6:139163364(+) A-I      intronic chr6:139180083(+) A-I      intronic chr6:139181007(+) A-I      intronic chr6:139176411(+) A-I      intronic chr6:139181008(+) A-I      intronic chr6:139120410(+) A-I      intronic chr6:139129944(+) A-I      intronic chr6:139224418(+) A-I      3'UTR chr6:139224507(+) A-I      3'UTR chr6:139224480(+) A-I      3'UTR chr6:139224308(+) A-I      3'UTR chr6:139224309(+) A-I      3'UTR chr6:139224347(+) A-I      3'UTR chr6:139224305(+) A-I      3'UTR chr6:139224299(+) A-I      3'UTR chr6:139224270(+) A-I      3'UTR chr6:139224311(+) A-I      3'UTR chr6:139224232(+) A-I      3'UTR chr6:139224315(+) A-I      3'UTR chr6:139224351(+) A-I      3'UTR chr6:139224355(+) A-I      3'UTR chr6:139224363(+) A-I      3'UTR chr6:139224373(+) A-I      3'UTR chr6:139130552(+) A-I      intronic chr6:139170845(+) A-I      intronic chr6:139160640(+) A-I      intronic chr6:139130590(+) A-I      intronic chr6:139181081(+) A-I      intronic chr6:139163851(+) A-I      intronic chr6:139133883(+) A-I      intronic chr6:139173187(+) A-I      intronic chr6:139224240(+) A-I      3'UTR chr6:139224442(+) A-I      3'UTR chr6:139129964(+) A-I      intronic chr6:139163318(+) A-I      intronic chr6:139148397(+) A-I      intronic chr6:139221463(+) A-I      intronic chr6:139130443(+) A-I      intronic chr6:139120777(+) A-I      intronic chr6:139180066(+) A-I      intronic chr6:139148456(+) A-I      intronic chr6:139129963(+) A-I      intronic chr6:139185023(+) A-I      intronic chr6:139129413(+) A-I      intronic chr6:139130444(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ECT2L	chr6:139200932(+) A-C intron -    22484847 chr6:139200959(+) A-G intron -    22484847 chr6:139200997(+) G-A intron -    22484847 chr6:139216161(+) T-C intron -    22484847 chr6:139216166(+) T-C intron -    22484847 chr6:139221583(+) T-C intron -    22484847 chr6:139224507(+) A-G intron -    22484847 chr6:139224508(+) G-A intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ECT2L	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: ECT2L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).