Detail Information

Basic Information:


  VIRBase ID:  

HHID00007747

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:           STEAP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19b-1-5p STEAP2
miRBase
Accession/Entrez ID		 MIMAT0004491 261729
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IPCA1//PCANAP1//PUMPCn//STAMP1//STMP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19b-1-5p
rs1330845252 chr13:91351221    G/A
rs771220050 chr13:91351229    C/T
rs1259633726 chr13:91351212    T/G
rs1279688822 chr13:91351213    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STEAP2
chr7:89869555(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STEAP2
chr7:89863926(+) A-G intron -    21725310
chr7:89864060(+) A-G intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STEAP2
chr7:89845839-89845840(+) m6A 5'UTR//exon//intron       22608085
chr7:89854651-89854652(+) m6A CDS//exon       24981863//26404942//22608085
chr7:89854683-89854684(+) m6A CDS//exon       24981863//26404942//22608085
chr7:89854703-89854704(+) m6A CDS//exon       24981863//26404942//22608085
chr7:89854710-89854711(+) m6A CDS//exon       24981863//26404942//22608085
chr7:89854763-89854764(+) m6A CDS//exon       24981863//26404942//22608085
chr7:89856516-89856517(+) m6A CDS       24981863//22608085
chr7:89856563-89856564(+) m6A CDS       24981863//22608085
chr7:89859324-89859325(+) m6A CDS       24981863
chr7:89861756-89861757(+) m6A CDS//intron       24981863//22608085
chr7:89866086-89866087(+) m6A 3'UTR//intron       24981863//22608085
chr7:89866231-89866232(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085
chr7:89866242-89866243(+) m6A 3'UTR//CDS//intron       25456834//24981863//22608085
chr7:89866491-89866492(+) m6A 3'UTR//intron       25456834//24981863//22608085
chr7:89866500-89866501(+) m6A 3'UTR//intron       25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19b-1-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
STEAP2
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19b-1-5p
Interactor2: STEAP2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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