Basic Information:

  VIRBase ID:  

HHID00007737

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          SPIN3:  NR_027139     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	SPIN3
miRBase Accession/Entrez ID	MIMAT0004491	169981
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bA445O16.1//SPIN-3//TDRD27

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPIN3	chrX:57003364-57003365(-) m6A 3'UTR       27773535 chrX:57003373-57003374(-) m6A 3'UTR       27773535 chrX:57003385-57003386(-) m6A 3'UTR       27773535 chrX:57003421-57003422(-) m6A 3'UTR       27773535 chrX:57020479-57020480(-) Y intron       26075521 chrX:57020611-57020612(-) m6A CDS//intron       22608085 chrX:57020675-57020676(-) m6A CDS//intron       24209618//24981863//27371828//22608085 chrX:57020707-57020708(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27371828//22608085 chrX:57020744-57020745(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27371828//22608085 chrX:57020760-57020761(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27371828//22608085 chrX:57020904-57020905(-) m6A CDS//intron       24209618//22608085 chrX:57020965-57020966(-) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chrX:57020978-57020979(-) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chrX:57021089-57021090(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chrX:57021169-57021170(-) m6A CDS       24284625 chrX:57021191-57021192(-) m6A CDS       24284625//24981863 chrX:57021237-57021238(-) m6A CDS       24981863 chrX:57021816-57021817(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	SPIN3	Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: SPIN3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).