Basic Information:

  VIRBase ID:  

HHID00007684

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          ATG4A:  NM_001321289     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	ATG4A
miRBase Accession/Entrez ID	MIMAT0004491	115201
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APG4A//AUTL2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATG4A	chrX:107355763(+) A-I      intronic chrX:107395545(+) A-I      intronic chrX:107355761(+) A-I      intronic chrX:107355751(+) A-I      intronic chrX:107353519(+) A-I      intronic chrX:107353546(+) A-I      intronic chrX:107353386(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATG4A	chrX:107334953-107334954(+) m6A 5'UTR       24981863 chrX:107334975-107334976(+) m6A 5'UTR       24981863 chrX:107335090-107335091(+) m6A 5'UTR//intron       24981863 chrX:107396952-107396953(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107396992-107396993(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107396998-107396999(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397012-107397013(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397055-107397056(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397100-107397101(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397105-107397106(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397110-107397111(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397115-107397116(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397151-107397152(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chrX:107397266-107397267(+) m6A 3'UTR       24284625//24981863//22608085 chrX:107397296-107397297(+) m6A 3'UTR       24284625//24981863//22608085 chrX:107397355-107397356(+) m6A 3'UTR       24981863//22608085 chrX:107397735-107397736(+) m6A 3'UTR       24981863 chrX:107397775-107397776(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ATG4A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: ATG4A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).