Basic Information:

  VIRBase ID:  

HHID00007442

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          APLN:  NM_017413     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	APLN
miRBase Accession/Entrez ID	MIMAT0004491	8862
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APEL//XNPEP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APLN	chrX:128780483-128780484(-) m6A 3'UTR       25456834 chrX:128780579-128780580(-) m6A 3'UTR       - chrX:128781382-128781383(-) m6A 3'UTR       25456834 chrX:128781417-128781418(-) m6A 3'UTR       25456834 chrX:128781566-128781567(-) m6A 3'UTR       24284625//25456834 chrX:128781643-128781644(-) m6A 3'UTR       24284625//25456834 chrX:128781656-128781657(-) m6A 3'UTR       24284625//25456834 chrX:128782617-128782618(-) m6A CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	APLN	Cytosol HeLa-S3 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: APLN

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).