Detail Information

Basic Information:


  VIRBase ID:  

HHID00007420

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:           VCP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19b-1-5p VCP
miRBase
Accession/Entrez ID		 MIMAT0004491 7415
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CDC48//FTDALS6//p97//TERA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19b-1-5p
rs1330845252 chr13:91351221    G/A
rs771220050 chr13:91351229    C/T
rs1259633726 chr13:91351212    T/G
rs1279688822 chr13:91351213    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VCP
chr9:35058515(-) A-I      intronic
chr9:35066380(-) A-I      intronic
chr9:35066350(-) A-I      intronic
chr9:35066165(-) A-I      intronic
chr9:35064453(-) A-I      intronic
chr9:35065113(-) A-I      intronic
chr9:35066015(-) A-I      intronic
chr9:35058516(-) A-I      intronic
chr9:35066348(-) A-I      intronic
chr9:35064509(-) A-I      intronic
chr9:35066040(-) A-I      intronic
chr9:35066036(-) A-I      intronic
chr9:35066076(-) A-I      intronic
chr9:35066183(-) A-I      intronic
chr9:35066184(-) A-I      intronic
chr9:35066210(-) A-I      intronic
chr9:35066499(-) A-I      intronic
chr9:35066503(-) A-I      intronic
chr9:35065138(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VCP
chr9:35056078-35056079(-) m6A 3'UTR       27773535
chr9:35056149-35056150(-) m6A 3'UTR       24284625//27773535
chr9:35056255-35056256(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr9:35056373-35056374(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr9:35056518-35056519(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr9:35056583-35056584(-) m6A 3'UTR       24284625//24981863//27773535
chr9:35056609-35056610(-) m6A 3'UTR       24284625//24981863//27773535
chr9:35056631-35056632(-) m6A 3'UTR       24284625//27773535
chr9:35056805-35056806(-) m6A 3'UTR       26404942//27773535//22575960
chr9:35056822-35056823(-) m6A 3'UTR       27773535//22575960
chr9:35056937-35056938(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35056966-35056967(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35056992-35056993(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057033-35057034(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057074-35057075(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057138-35057139(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960
chr9:35057204-35057205(-) m6A CDS//exon       24209618//26404942//27773535//22575960
chr9:35057406-35057407(-) m6A CDS//exon       27773535//22575960
chr9:35057605-35057606(-) m6A exon//intron       24981863//27773535
chr9:35057613-35057614(-) m6A exon//intron       24981863//27773535
chr9:35057819-35057820(-) m6A exon//intron       24981863//26404942
chr9:35059077-35059078(-) m6A CDS//exon       24981863//26404942//22575960
chr9:35059208-35059209(-) m6A CDS//exon       26404942//22575960
chr9:35059842-35059843(-) m6A exon//intron       22575960
chr9:35060846-35060847(-) m6A CDS//exon       26404942//27773535
chr9:35060880-35060881(-) m6A CDS//exon       26404942//27773535
chr9:35061042-35061043(-) m6A CDS//exon       26404942//27773535//22575960
chr9:35061064-35061065(-) m6A CDS//exon       26404942//22575960
chr9:35061163-35061164(-) m6A CDS//exon       26404942
chr9:35061576-35061577(-) m6A CDS//exon       26404942
chr9:35061583-35061584(-) m6A CDS//exon       26404942
chr9:35061607-35061608(-) m6A CDS//exon       26404942
chr9:35062033-35062034(-) m6A CDS//exon       24981863//26404942
chr9:35062134-35062135(-) m6A CDS//exon       24981863//26404942//22575960
chr9:35062151-35062152(-) m6A exon//intron       24981863//26404942//22575960
chr9:35063031-35063032(-) m6A CDS//exon       26404942
chr9:35063040-35063041(-) m6A CDS//exon       26404942
chr9:35063050-35063051(-) m6A CDS//exon       26404942
chr9:35064183-35064184(-) m6A CDS//exon       26404942
chr9:35064195-35064196(-) m6A CDS//exon       26404942//22575960
chr9:35065287-35065288(-) m6A CDS//exon       26404942
chr9:35068272-35068273(-) m6A 5'UTR//CDS//exon       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19b-1-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
VCP
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19b-1-5p
Interactor2: VCP

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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