Detail Information

Basic Information:


  VIRBase ID:  

HHID00007399

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:           MAP2K4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19b-1-5p MAP2K4
miRBase
Accession/Entrez ID		 MIMAT0004491 6416
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - JNKK//JNKK1//MAPKK4//MEK4//MKK4//PRKMK4//SAPKK-1//SAPKK1//SEK1//SERK1//SKK1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19b-1-5p
rs1330845252 chr13:91351221    G/A
rs771220050 chr13:91351229    C/T
rs1259633726 chr13:91351212    T/G
rs1279688822 chr13:91351213    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAP2K4
chr17:11952091(+) A-I      intronic
chr17:11952103(+) A-I      intronic
chr17:11952074(+) A-I      intronic
chr17:11952073(+) A-I      intronic
chr17:11952048(+) A-I      intronic
chr17:11952058(+) A-I      intronic
chr17:11968752(+) A-I      intronic
chr17:11967539(+) A-I      intronic
chr17:11967478(+) A-I      intronic
chr17:11967475(+) A-I      intronic
chr17:11967279(+) A-I      intronic
chr17:11936236(+) A-I      intronic
chr17:11969916(+) A-I      intronic
chr17:11967277(+) A-I      intronic
chr17:11967105(+) A-I      intronic
chr17:11961634(+) A-I      intronic
chr17:11936427(+) A-I      intronic
chr17:11936283(+) A-I      intronic
chr17:11967557(+) A-I      intronic
chr17:11969910(+) A-I      intronic
chr17:11938615(+) A-I      intronic
chr17:11961656(+) A-I      intronic
chr17:11963384(+) A-I      intronic
chr17:11967483(+) A-I      intronic
chr17:11967169(+) A-I      intronic
chr17:11938714(+) A-I      intronic
chr17:11946110(+) A-I      intronic
chr17:11967477(+) A-I      intronic
chr17:11967673(+) A-I      intronic
chr17:11967634(+) A-I      intronic
chr17:11965920(+) A-I      intronic
chr17:11967476(+) A-I      intronic
chr17:11967043(+) A-I      intronic
chr17:11992368(+) A-I      intronic
chr17:11963240(+) A-I      intronic
chr17:11967040(+) A-I      intronic
chr17:11992358(+) A-I      intronic
chr17:11936300(+) A-I      intronic
chr17:11967667(+) A-I      intronic
chr17:11936253(+) A-I      intronic
chr17:11967104(+) A-I      intronic
chr17:11946109(+) A-I      intronic
chr17:11997240(+) A-I      intronic
chr17:11967106(+) A-I      intronic
chr17:11967633(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAP2K4
chr17:12044465-12044466(+) m6A 3'UTR//CDS//exon       22608085
chr17:12044594-12044595(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:12044674-12044675(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:12044791-12044792(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr17:12044816-12044817(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr17:12044893-12044894(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12044900-12044901(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12044937-12044938(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12044956-12044957(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12044983-12044984(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12044991-12044992(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12045030-12045031(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:12045055-12045056(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:12045214-12045215(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12045238-12045239(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12045254-12045255(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12045259-12045260(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12045308-12045309(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12045407-12045408(+) m6A 3'UTR//exon       24981863
chr17:12046290-12046291(+) m6A 3'UTR//exon       24284625
chr17:12046410-12046411(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12046417-12046418(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12046440-12046441(+) m6A 3'UTR//exon       24284625//22608085
chr17:12046499-12046500(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12046681-12046682(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12046688-12046689(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr17:12046729-12046730(+) m6A 3'UTR//exon       24981863//22608085
chr17:12046754-12046755(+) m6A 3'UTR//exon       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19b-1-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
MAP2K4
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19b-1-5p
Interactor2: MAP2K4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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