Basic Information:

  VIRBase ID:  

HHID00007359

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          MCM5:  NM_006739     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	MCM5
miRBase Accession/Entrez ID	MIMAT0004491	4174
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDC46//MGORS8//P1-CDC46

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MCM5	chr22:35805366(+) A-I      intronic chr22:35805020(+) A-I      intronic chr22:35798811(+) A-I      intronic chr22:35798676(+) A-I      intronic chr22:35798702(+) A-I      intronic chr22:35805357(+) A-I      intronic chr22:35805293(+) A-I      intronic chr22:35805036(+) A-I      intronic chr22:35801460(+) A-I      intronic chr22:35798211(+) A-I      intronic chr22:35801794(+) A-I      intronic chr22:35805230(+) A-I      intronic chr22:35798776(+) A-I      intronic chr22:35798221(+) A-I      intronic chr22:35801948(+) A-I      intronic chr22:35801634(+) A-I      intronic chr22:35798799(+) A-I      intronic chr22:35801748(+) A-I      intronic chr22:35805444(+) A-I      intronic chr22:35801088(+) A-I      intronic chr22:35805097(+) A-I      intronic chr22:35805312(+) A-I      intronic chr22:35799981(+) A-I      intronic chr22:35801434(+) A-I      intronic chr22:35816966(+) A-I      intronic chr22:35805381(+) A-I      intronic chr22:35801459(+) A-I      intronic chr22:35801857(+) A-I      intronic chr22:35801747(+) A-I      intronic chr22:35805095(+) A-I      intronic chr22:35805447(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MCM5	chr22:35798215(+) A-G intron -    22484847 chr22:35798737(+) A-G intron -    22484847 chr22:35805085(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MCM5	chr22:35796113-35796114(+) m6A 5'UTR       - chr22:35796139-35796140(+) m6A 5'UTR//exon       - chr22:35796194-35796195(+) m6A 5'UTR//intron       24284625 chr22:35797762-35797763(+) m6A 3'UTR//intron       - chr22:35799205-35799206(+) m6A 3'UTR//CDS//intron       - chr22:35799279-35799280(+) m6A CDS//intron       22575960 chr22:35799479-35799480(+) m6A CDS//intron       22575960 chr22:35802549-35802550(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr22:35804432-35804433(+) m6A CDS//intron       22575960 chr22:35806765-35806766(+) m6A CDS//exon       24284625 chr22:35806888-35806889(+) m6A CDS//exon       24284625 chr22:35807261-35807262(+) m6A exon//intron       24284625 chr22:35807269-35807270(+) m6A exon//intron       24284625 chr22:35808625-35808626(+) m6A CDS//exon       22575960 chr22:35809879-35809880(+) m6A CDS//exon       22575960 chr22:35809896-35809897(+) m6A CDS//exon       22575960 chr22:35809920-35809921(+) m6A CDS//exon       22575960 chr22:35809928-35809929(+) m6A CDS//exon       22575960 chr22:35811856-35811857(+) m6A CDS//exon       22575960 chr22:35811879-35811880(+) m6A CDS//exon       22575960 chr22:35812379-35812380(+) m6A CDS//exon       22575960 chr22:35812652-35812653(+) m6A CDS//exon       22575960 chr22:35813784-35813785(+) m6A CDS//exon       22575960 chr22:35815915-35815916(+) m6A CDS//exon       22575960 chr22:35815923-35815924(+) m6A CDS//exon       22575960 chr22:35819233-35819234(+) m6A CDS//exon       - chr22:35819320-35819321(+) m6A CDS//exon       24284625//22575960 chr22:35819427-35819428(+) m6A exon//intron       24284625//24209618 chr22:35819453-35819454(+) m6A exon//intron       24284625//24209618 chr22:35819472-35819473(+) m6A exon//intron       24284625//24209618 chr22:35820266-35820267(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:35820274-35820275(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:35820329-35820330(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:35820357-35820358(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:35820399-35820400(+) Y 3'UTR//exon       25219674//26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	MCM5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: MCM5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).